Peringatan Keamanan

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Methylergometrine

DB00353

small molecule approved

Deskripsi

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)

Struktur Molekul 2D

Berat 339.4314
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3.39 hours
Volume Distribusi * 56.1 ± 0 L
Klirens (Clearance) -

Absorpsi

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Metabolisme

Hepatic, with extensive first-pass metabolism.

Rute Eliminasi

Ergot alkaloids are mostly eliminated by hepatic metabolism and excretion, and the decrease in bioavailability following oral administration is probably a result of first-pass metabolism in the liver.

Interaksi Makanan

1 Data
  • 1. Avoid grapefruit products. Grapefruit inhibits the metabolism of methylergometrine through the CYP3A4 pathway and, therefore, may increase serum levels of methylergometrine. Use caution if co-administering.

Interaksi Obat

832 Data
Carboprost tromethamine Carboprost tromethamine may increase the uterotonic activities of Methylergometrine.
Valsartan Methylergometrine may decrease the antihypertensive activities of Valsartan.
Ramipril Methylergometrine may decrease the antihypertensive activities of Ramipril.
Reserpine Methylergometrine may decrease the antihypertensive activities of Reserpine.
Remikiren Methylergometrine may decrease the antihypertensive activities of Remikiren.
Torasemide Methylergometrine may decrease the antihypertensive activities of Torasemide.
Guanadrel Methylergometrine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Methylergometrine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Methylergometrine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Methylergometrine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Methylergometrine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Methylergometrine may decrease the antihypertensive activities of Treprostinil.
Bendroflumethiazide Methylergometrine may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Methylergometrine may decrease the antihypertensive activities of Prazosin.
Fosinopril Methylergometrine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Methylergometrine may decrease the antihypertensive activities of Trandolapril.
Metolazone Methylergometrine may decrease the antihypertensive activities of Metolazone.
Benazepril Methylergometrine may decrease the antihypertensive activities of Benazepril.
Cyclothiazide Methylergometrine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Methylergometrine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Methylergometrine may decrease the antihypertensive activities of Mecamylamine.
Moexipril Methylergometrine may decrease the antihypertensive activities of Moexipril.
Lisinopril Methylergometrine may decrease the antihypertensive activities of Lisinopril.
Metyrosine Methylergometrine may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide Methylergometrine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Methylergometrine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Methylergometrine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Methylergometrine may decrease the antihypertensive activities of Candesartan cilexetil.
Eprosartan Methylergometrine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Methylergometrine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Methylergometrine may decrease the antihypertensive activities of Quinapril.
Telmisartan Methylergometrine may decrease the antihypertensive activities of Telmisartan.
Hydrochlorothiazide Methylergometrine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Methylergometrine may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Methylergometrine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Methylergometrine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Methylergometrine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Methylergometrine may decrease the antihypertensive activities of Diazoxide.
Bretylium Methylergometrine may decrease the antihypertensive activities of Bretylium.
Terazosin Methylergometrine may decrease the antihypertensive activities of Terazosin.
Captopril Methylergometrine may decrease the antihypertensive activities of Captopril.
Epoprostenol Methylergometrine may decrease the antihypertensive activities of Epoprostenol.
Polythiazide Methylergometrine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Methylergometrine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Methylergometrine may decrease the antihypertensive activities of Saprisartan.
Spirapril Methylergometrine may decrease the antihypertensive activities of Spirapril.
Tienilic acid Methylergometrine may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Methylergometrine may decrease the antihypertensive activities of Debrisoquine.
Diethylnorspermine Methylergometrine may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Methylergometrine may decrease the antihypertensive activities of Temocapril.
Hexamethonium Methylergometrine may decrease the antihypertensive activities of Hexamethonium.
Trimazosin Methylergometrine may decrease the antihypertensive activities of Trimazosin.
Nicorandil Methylergometrine may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Methylergometrine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Methylergometrine may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Methylergometrine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Methylergometrine may decrease the antihypertensive activities of Imidapril.
BQ-123 Methylergometrine may decrease the antihypertensive activities of BQ-123.
Cicletanine Methylergometrine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Methylergometrine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Methylergometrine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Methylergometrine may decrease the antihypertensive activities of Guanoxan.
Delapril Methylergometrine may decrease the antihypertensive activities of Delapril.
Vincamine Methylergometrine may decrease the antihypertensive activities of Vincamine.
Linsidomine Methylergometrine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Methylergometrine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Methylergometrine may decrease the antihypertensive activities of Tolonidine.
Endralazine Methylergometrine may decrease the antihypertensive activities of Endralazine.
Cadralazine Methylergometrine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Methylergometrine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Methylergometrine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Methylergometrine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Methylergometrine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Methylergometrine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Methylergometrine may decrease the antihypertensive activities of Muzolimine.
Xipamide Methylergometrine may decrease the antihypertensive activities of Xipamide.
Candesartan Methylergometrine may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Methylergometrine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Methylergometrine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Methylergometrine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Methylergometrine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Methylergometrine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Methylergometrine may decrease the antihypertensive activities of Quinaprilat.
Furosemide Methylergometrine may decrease the antihypertensive activities of Furosemide.
Enalapril Methylergometrine may decrease the antihypertensive activities of Enalapril.
Amlodipine Methylergometrine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Methylergometrine may decrease the antihypertensive activities of Nimodipine.
Lercanidipine Methylergometrine may decrease the antihypertensive activities of Lercanidipine.
Bosentan Methylergometrine may decrease the antihypertensive activities of Bosentan.
Losartan Methylergometrine may decrease the antihypertensive activities of Losartan.
Indapamide Methylergometrine may decrease the antihypertensive activities of Indapamide.
Irbesartan Methylergometrine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Methylergometrine may decrease the antihypertensive activities of Nitrendipine.
Guanethidine Methylergometrine may decrease the antihypertensive activities of Guanethidine.
Bepridil Methylergometrine may decrease the antihypertensive activities of Bepridil.
Hydralazine Methylergometrine may decrease the antihypertensive activities of Hydralazine.
Mibefradil Methylergometrine may decrease the antihypertensive activities of Mibefradil.
Sitaxentan Methylergometrine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Methylergometrine may decrease the antihypertensive activities of Ambrisentan.
Pinacidil Methylergometrine may decrease the antihypertensive activities of Pinacidil.

Target Protein

D(1A) dopamine receptor DRD1
5-hydroxytryptamine receptor 2B HTR2B

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 36 • International brands: 40
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Menampilkan 8 dari 36 produk.
International Brands
  • Basofortina — Novartis
  • Bledstop — Caprifarmindo
  • Demergin — Demo
  • Ergogin — Cipla
  • Ergomed — Medlink
  • Ergomin — Alico Impex
  • Ergotyl — Sandoz
  • Expogin — L.B.S.
  • Glomethyl — Metiska
  • Ingagen-M — Inga

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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