Peringatan Keamanan

No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day. Treatment with megestrol acetate, an orexigenic agent, has also resulted in iatrogenic adrenal suppression. The mechanism is presumably related to the glucocorticoid properties of megestrol acetate PMID: 12872362.

Megestrol acetate

DB00351

small molecule approved investigational vet_approved

Deskripsi

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.

Struktur Molekul 2D

Berat 384.516
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 34 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Variable, but well absorbed orally.

Metabolisme

Primarily hepatic. Megestrol metabolites which were identified in urine constituted 5% to 8% of the dose administered. Respiratory excretion as labeled carbon dioxide and fat storage may have accounted for at least part of the radioactivity not found in urine and feces. No active metabolites have been identified.

Rute Eliminasi

The major route of drug elimination in humans is urine. Respiratory excretion as labeled carbon dioxide and fat storage may have accounted for at least part of the radioactivity not found in urine and feces.

Interaksi Makanan

1 Data
  • 1. Take with food.

Interaksi Obat

1263 Data
Acitretin The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Acitretin.
Aprepitant The serum concentration of Megestrol acetate can be decreased when it is combined with Aprepitant.
Atazanavir The serum concentration of Megestrol acetate can be increased when it is combined with Atazanavir.
Boceprevir The serum concentration of Megestrol acetate can be increased when it is combined with Boceprevir.
Prucalopride The serum concentration of Megestrol acetate can be decreased when it is combined with Prucalopride.
Sugammadex The serum concentration of Megestrol acetate can be decreased when it is combined with Sugammadex.
Thalidomide Megestrol acetate may increase the thrombogenic activities of Thalidomide.
Ulipristal The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Ulipristal.
Dofetilide Megestrol acetate may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Ursodeoxycholic acid The therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Megestrol acetate.
Glycochenodeoxycholic Acid The therapeutic efficacy of Glycochenodeoxycholic Acid can be decreased when used in combination with Megestrol acetate.
Cholic Acid The therapeutic efficacy of Cholic Acid can be decreased when used in combination with Megestrol acetate.
Glycocholic acid The therapeutic efficacy of Glycocholic acid can be decreased when used in combination with Megestrol acetate.
Deoxycholic acid The therapeutic efficacy of Deoxycholic acid can be decreased when used in combination with Megestrol acetate.
Obeticholic acid The therapeutic efficacy of Obeticholic acid can be decreased when used in combination with Megestrol acetate.
Tauroursodeoxycholic acid The therapeutic efficacy of Tauroursodeoxycholic acid can be decreased when used in combination with Megestrol acetate.
Bamet-UD2 The therapeutic efficacy of Bamet-UD2 can be decreased when used in combination with Megestrol acetate.
cis-Diamminechlorocholylglycinateplatinum(II) The therapeutic efficacy of cis-Diamminechlorocholylglycinateplatinum(II) can be decreased when used in combination with Megestrol acetate.
Dehydrocholic acid The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Megestrol acetate.
Hyodeoxycholic Acid The therapeutic efficacy of Hyodeoxycholic Acid can be decreased when used in combination with Megestrol acetate.
Aramchol The therapeutic efficacy of Aramchol can be decreased when used in combination with Megestrol acetate.
Ox bile extract The therapeutic efficacy of Ox bile extract can be decreased when used in combination with Megestrol acetate.
Chenodeoxycholic acid The therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Megestrol acetate.
Taurochenodeoxycholic acid The therapeutic efficacy of Taurochenodeoxycholic acid can be decreased when used in combination with Megestrol acetate.
Taurocholic acid The therapeutic efficacy of Taurocholic acid can be decreased when used in combination with Megestrol acetate.
Tranexamic acid Megestrol acetate may increase the thrombogenic activities of Tranexamic acid.
Clobazam The serum concentration of Megestrol acetate can be decreased when it is combined with Clobazam.
Colestipol Colestipol can cause a decrease in the absorption of Megestrol acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Megestrol acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colesevelam Colesevelam can cause a decrease in the absorption of Megestrol acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholestyramine Cholestyramine can cause a decrease in the absorption of Megestrol acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Griseofulvin The metabolism of Megestrol acetate can be increased when combined with Griseofulvin.
Fluocortin The serum concentration of Fluocortin can be increased when it is combined with Megestrol acetate.
Fluperolone The serum concentration of Fluperolone can be increased when it is combined with Megestrol acetate.
Fluclorolone The serum concentration of Fluclorolone can be increased when it is combined with Megestrol acetate.
Flunisolide The serum concentration of Flunisolide can be increased when it is combined with Megestrol acetate.
Beclomethasone dipropionate The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Megestrol acetate.
Fluocinolone acetonide The serum concentration of Fluocinolone acetonide can be increased when it is combined with Megestrol acetate.
Triamcinolone The serum concentration of Triamcinolone can be increased when it is combined with Megestrol acetate.
Corticotropin The serum concentration of Corticotropin can be increased when it is combined with Megestrol acetate.
Cortisone acetate The serum concentration of Cortisone acetate can be increased when it is combined with Megestrol acetate.
Fluprednidene The serum concentration of Fluprednidene can be increased when it is combined with Megestrol acetate.
Meprednisone The serum concentration of Meprednisone can be increased when it is combined with Megestrol acetate.
Dexamethasone isonicotinate The serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Megestrol acetate.
Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Megestrol acetate.
Cortivazol The serum concentration of Cortivazol can be increased when it is combined with Megestrol acetate.
Prednylidene The serum concentration of Prednylidene can be increased when it is combined with Megestrol acetate.
Cloprednol The serum concentration of Cloprednol can be increased when it is combined with Megestrol acetate.
Mometasone furoate The serum concentration of Mometasone furoate can be increased when it is combined with Megestrol acetate.
Hydrocortisone acetate The serum concentration of Hydrocortisone acetate can be increased when it is combined with Megestrol acetate.
Hydrocortisone succinate The serum concentration of Hydrocortisone succinate can be increased when it is combined with Megestrol acetate.
Prednisolone phosphate The serum concentration of Prednisolone phosphate can be increased when it is combined with Megestrol acetate.
Prednisolone hemisuccinate The serum concentration of Prednisolone hemisuccinate can be increased when it is combined with Megestrol acetate.
Methylprednisolone hemisuccinate The serum concentration of Methylprednisolone hemisuccinate can be increased when it is combined with Megestrol acetate.
Prednisone acetate The serum concentration of Prednisone acetate can be increased when it is combined with Megestrol acetate.
Clocortolone acetate The serum concentration of Clocortolone acetate can be increased when it is combined with Megestrol acetate.
Melengestrol acetate The serum concentration of Melengestrol acetate can be increased when it is combined with Megestrol acetate.
Betamethasone phosphate The serum concentration of Betamethasone phosphate can be increased when it is combined with Megestrol acetate.
Cortisone The serum concentration of Cortisone can be increased when it is combined with Megestrol acetate.
Betamethasone The serum concentration of Betamethasone can be increased when it is combined with Megestrol acetate.
Fluticasone propionate The serum concentration of Fluticasone propionate can be increased when it is combined with Megestrol acetate.
Prednisone The serum concentration of Prednisone can be increased when it is combined with Megestrol acetate.
Hydrocortisone The serum concentration of Hydrocortisone can be increased when it is combined with Megestrol acetate.
Prednisolone The serum concentration of Prednisolone can be increased when it is combined with Megestrol acetate.
Methylprednisolone The serum concentration of Methylprednisolone can be increased when it is combined with Megestrol acetate.
Aldosterone The serum concentration of Aldosterone can be increased when it is combined with Megestrol acetate.
Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Megestrol acetate.
Fluticasone The serum concentration of Fluticasone can be increased when it is combined with Megestrol acetate.
Tixocortol The serum concentration of Tixocortol can be increased when it is combined with Megestrol acetate.
Budesonide The serum concentration of Budesonide can be increased when it is combined with Megestrol acetate.
Dexamethasone The serum concentration of Dexamethasone can be increased when it is combined with Megestrol acetate.
Fludrocortisone The serum concentration of Fludrocortisone can be increased when it is combined with Megestrol acetate.
Trilostane The serum concentration of Trilostane can be increased when it is combined with Megestrol acetate.
Paramethasone The serum concentration of Paramethasone can be increased when it is combined with Megestrol acetate.
Ciclesonide The serum concentration of Ciclesonide can be increased when it is combined with Megestrol acetate.
Fluprednisolone The serum concentration of Fluprednisolone can be increased when it is combined with Megestrol acetate.
Melengestrol The serum concentration of Melengestrol can be increased when it is combined with Megestrol acetate.
Hydrocortisone cypionate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Megestrol acetate.
Clobetasol propionate The serum concentration of Clobetasol propionate can be increased when it is combined with Megestrol acetate.
Fluocinonide The serum concentration of Fluocinonide can be increased when it is combined with Megestrol acetate.
Hydrocortisone butyrate The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Megestrol acetate.
Desoximetasone The serum concentration of Desoximetasone can be increased when it is combined with Megestrol acetate.
Mometasone The serum concentration of Mometasone can be increased when it is combined with Megestrol acetate.
Fluocortolone The serum concentration of Fluocortolone can be increased when it is combined with Megestrol acetate.
Prednisolone acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Megestrol acetate.
Fluorometholone The serum concentration of Fluorometholone can be increased when it is combined with Megestrol acetate.
Difluocortolone The serum concentration of Difluocortolone can be increased when it is combined with Megestrol acetate.
Flumethasone The serum concentration of Flumethasone can be increased when it is combined with Megestrol acetate.
Methylprednisolone aceponate The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Megestrol acetate.
Vitamin A The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Vitamin A.
Bexarotene The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Bexarotene.
Alitretinoin The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Alitretinoin.
Tretinoin The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Tretinoin.
Tazarotene The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Tazarotene.
Etretinate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Etretinate.
4-Oxoretinol The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with 4-Oxoretinol.
Fenretinide The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Fenretinide.
Ro 12-7310 The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Ro 12-7310.
Zuretinol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Zuretinol acetate.
Motretinide The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Motretinide.

Target Protein

Progesterone receptor PGR
Glucocorticoid receptor NR3C1

Referensi & Sumber

Synthesis reference: Klaus ANNEN, Thomas Linz, Karl-Heinz Neff, Rolf Bohlmann, Henry Laurent, "PROCESS FOR PREPARING 17ALPHA-ACETOXY-6-METHYLENEPREGN-4-ENE-3,20-DIONE, MEDROXYPROGESTERONE ACETATE AND MEGESTROL ACETATE." U.S. Patent US20090012321, issued January 08, 2009.
Artikel (PubMed)
  • PMID: 15846706
    Berenstein EG, Ortiz Z: Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004310.
  • PMID: 15050664
    Pascual Lopez A, Roque i Figuls M, Urrutia Cuchi G, Berenstein EG, Almenar Pasies B, Balcells Alegre M, Herdman M: Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome. J Pain Symptom Manage. 2004 Apr;27(4):360-9.
  • PMID: 16375643
    Rao GG, Miller DS: Hormonal therapy in epithelial ovarian cancer. Expert Rev Anticancer Ther. 2006 Jan;6(1):43-7.
  • PMID: 19434889
    Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH: Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct;61(1-2):171-80.
  • PMID: 12872362
    Orme LM, Bond JD, Humphrey MS, Zacharin MR, Downie PA, Jamsen KM, Mitchell SL, Robinson JM, Grapsas NA, Ashley DM: Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression. Cancer. 2003 Jul 15;98(2):397-405.

Contoh Produk & Brand

Produk: 94 • International brands: 4
Produk
  • Apo-megestrol
    Tablet • 40 mg • Oral • Canada • Generic • Approved
  • Apo-megestrol
    Tablet • 160 mg • Oral • Canada • Generic • Approved
  • Linmegestrol - Tab 160mg
    Tablet • 160 mg • Oral • Canada • Approved
  • Linmegestrol - Tab 40mg
    Tablet • 40 mg • Oral • Canada • Approved
  • Megace
    Tablet • 20 mg/1 • Oral • US • Approved
  • Megace
    Tablet • 40 mg/1 • Oral • US • Approved
  • Megace
    Suspension • 40 mg/1mL • Oral • US • Approved
  • Megace
    Suspension • 40 mg/1mL • Oral • US • Approved
Menampilkan 8 dari 94 produk.
International Brands
  • Maygace
  • Megestat
  • Megestil
  • Megestin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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