Peringatan Keamanan

Oral LD50 in rats has ranged from 1321-3492 mg/kg; in mice, 2456-2648 mg/kg. Side effects include cardiovascular effects associated with hypotension such as sudden weight gain, rapid heart beat, faintness or dizziness.

Minoxidil

DB00350

small molecule approved investigational

Deskripsi

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.

Struktur Molekul 2D

Berat 209.2483
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 4.2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Minoxidil is at least 90% absorbed from the GI tract in experimental animals and man.

Metabolisme

Approximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products. Known metabolites exert much less pharmacologic effect than minoxidil itself.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

687 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Minoxidil is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Minoxidil is combined with Levodopa.
Risperidone Minoxidil may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Minoxidil.
Amifostine Minoxidil may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Minoxidil.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Minoxidil.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Minoxidil.
Obinutuzumab Minoxidil may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Minoxidil.
Rituximab Minoxidil may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Minoxidil.
Phentermine Phentermine may decrease the antihypertensive activities of Minoxidil.
Midodrine Midodrine may decrease the antihypertensive activities of Minoxidil.
Eletriptan Eletriptan may decrease the antihypertensive activities of Minoxidil.
Isoetharine Isoetharine may decrease the antihypertensive activities of Minoxidil.
Methysergide Methysergide may decrease the antihypertensive activities of Minoxidil.
Cabergoline Cabergoline may decrease the antihypertensive activities of Minoxidil.
Atomoxetine Atomoxetine may decrease the antihypertensive activities of Minoxidil.
Etomidate Etomidate may decrease the antihypertensive activities of Minoxidil.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Minoxidil.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Minoxidil.
Protriptyline Protriptyline may decrease the antihypertensive activities of Minoxidil.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Minoxidil.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Minoxidil.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Minoxidil.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Minoxidil.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Minoxidil.
Promazine Promazine may decrease the antihypertensive activities of Minoxidil.
Droperidol Droperidol may decrease the antihypertensive activities of Minoxidil.
Buspirone Buspirone may decrease the antihypertensive activities of Minoxidil.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Minoxidil.
Amoxapine Amoxapine may decrease the antihypertensive activities of Minoxidil.
Doxapram Doxapram may decrease the antihypertensive activities of Minoxidil.
Atropine Atropine may decrease the antihypertensive activities of Minoxidil.
Lisuride Lisuride may decrease the antihypertensive activities of Minoxidil.
Metaraminol Metaraminol may decrease the antihypertensive activities of Minoxidil.
Trazodone Trazodone may decrease the antihypertensive activities of Minoxidil.
Epinephrine Epinephrine may decrease the antihypertensive activities of Minoxidil.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Minoxidil.
Ergotamine Ergotamine may decrease the antihypertensive activities of Minoxidil.
Nicergoline Nicergoline may decrease the antihypertensive activities of Minoxidil.
Methoxamine Methoxamine may decrease the antihypertensive activities of Minoxidil.
Trimipramine Trimipramine may decrease the antihypertensive activities of Minoxidil.
Propiomazine Propiomazine may decrease the antihypertensive activities of Minoxidil.
Alfentanil Alfentanil may decrease the antihypertensive activities of Minoxidil.
Fentanyl Fentanyl may decrease the antihypertensive activities of Minoxidil.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Minoxidil.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Minoxidil.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Minoxidil.
Dobutamine Dobutamine may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Minoxidil.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Minoxidil.
Ritodrine Ritodrine may decrease the antihypertensive activities of Minoxidil.
Terbutaline Terbutaline may decrease the antihypertensive activities of Minoxidil.
Flupentixol Flupentixol may decrease the antihypertensive activities of Minoxidil.
Bitolterol Bitolterol may decrease the antihypertensive activities of Minoxidil.
Quinidine Quinidine may decrease the antihypertensive activities of Minoxidil.
Almotriptan Almotriptan may decrease the antihypertensive activities of Minoxidil.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Minoxidil.
Salmeterol Salmeterol may decrease the antihypertensive activities of Minoxidil.
Naratriptan Naratriptan may decrease the antihypertensive activities of Minoxidil.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Minoxidil.
Formoterol Formoterol may decrease the antihypertensive activities of Minoxidil.
Dopamine Dopamine may decrease the antihypertensive activities of Minoxidil.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Minoxidil.
Albuterol Salbutamol may decrease the antihypertensive activities of Minoxidil.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Minoxidil.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Minoxidil.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Minoxidil.
Arbutamine Arbutamine may decrease the antihypertensive activities of Minoxidil.
Dutasteride Dutasteride may decrease the antihypertensive activities of Minoxidil.
Doxepin Doxepin may decrease the antihypertensive activities of Minoxidil.
Nefazodone Nefazodone may decrease the antihypertensive activities of Minoxidil.
Desipramine Desipramine may decrease the antihypertensive activities of Minoxidil.
Propafenone Propafenone may decrease the antihypertensive activities of Minoxidil.
Pergolide Pergolide may decrease the antihypertensive activities of Minoxidil.
Finasteride Finasteride may decrease the antihypertensive activities of Minoxidil.
Ergometrine Ergometrine may decrease the antihypertensive activities of Minoxidil.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Minoxidil.
Paliperidone Paliperidone may decrease the antihypertensive activities of Minoxidil.
Arformoterol Arformoterol may decrease the antihypertensive activities of Minoxidil.
Fenoterol Fenoterol may decrease the antihypertensive activities of Minoxidil.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Minoxidil.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Minoxidil.
Ephedrine Ephedrine may decrease the antihypertensive activities of Minoxidil.
Mephentermine Mephentermine may decrease the antihypertensive activities of Minoxidil.
Procaterol Procaterol may decrease the antihypertensive activities of Minoxidil.
Yohimbine Yohimbine may decrease the antihypertensive activities of Minoxidil.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Minoxidil.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Minoxidil.
Bambuterol Bambuterol may decrease the antihypertensive activities of Minoxidil.
MMDA MMDA may decrease the antihypertensive activities of Minoxidil.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Minoxidil.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Minoxidil.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Minoxidil.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Minoxidil.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Minoxidil.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Minoxidil.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Minoxidil.

Target Protein

ATP-sensitive inward rectifier potassium channel 1 KCNJ1
Renin REN
Prostaglandin G/H synthase 1 PTGS1

Referensi & Sumber

Synthesis reference: Paul S. Uster, Yolanda P. Quinn, "Non-crystalline minoxidil composition, its production and application." U.S. Patent US4828837, issued March, 1985.
Artikel (PubMed)
  • PMID: 17761356
    Olsen EA, Whiting D, Bergfeld W, Miller J, Hordinsky M, Wanser R, Zhang P, Kohut B: A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol. 2007 Nov;57(5):767-74. Epub 2007 Aug 29.

Contoh Produk & Brand

Produk: 549 • International brands: 14
Produk
  • 2% Minoxidil hair growth oil
    Liquid • 2 g/100mL • Topical • US • Generic • OTC • Approved
  • 2% Minoxidil Hair regrowth serum
    Spray • 2 g/100mL • Topical • US • Generic • OTC • Approved
  • 3RX Minoxidil HAIR REGROWTH TREATMENT FOR MEN
    Liquid • 5 g/100mL • Topical • US • OTC
  • 5% Minoxidil
    Oil • 5 g/100mL • Topical • US • Generic • OTC • Approved
  • 5% Minoxidil Beard Growth Serum
    Liquid • 5 g/100mL • Topical • US • Generic • OTC • Approved
  • 5% Minoxidil Foam
    Spray, suspension • 5 g/100g • Topical • US • Generic • OTC • Approved
  • 5% Minoxidil Foam
    Spray, suspension • 5 g/100g • Topical • US • Generic • OTC • Approved
  • 5% Minoxidil Foam
    Liquid • 5 g/100mL • Topical • US • Generic • OTC • Approved
Menampilkan 8 dari 549 produk.
International Brands
  • Alostil — McNeil
  • Apo-Gain — Apotex
  • Avogain
  • Lipogaine
  • Lonolox — Pfizer
  • Minodyl
  • Minoximen — Menarini
  • Mintop — Dr. Reddy's
  • Normoxidil
  • Regaine — McNeil

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul