Side effects include anxiety, blood disorders, confusion, decreased libido, dizziness, flushing, headache, impotence, insomnia, low blood pressure, nightmares, rapid or irregular heartbeat, rash, seizures, sensitivity to sunlight, stomach and intestinal discomfort, sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, alpha1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Valsartan | Protriptyline may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Protriptyline may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Protriptyline may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Protriptyline may decrease the antihypertensive activities of Torasemide. |
| Guanadrel | Protriptyline may decrease the antihypertensive activities of Guanadrel. |
| Olmesartan | Protriptyline may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Protriptyline may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Protriptyline may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Protriptyline may decrease the antihypertensive activities of Minoxidil. |
| Nisoldipine | Protriptyline may decrease the antihypertensive activities of Nisoldipine. |
| Bendroflumethiazide | Protriptyline may decrease the antihypertensive activities of Bendroflumethiazide. |
| Fosinopril | Protriptyline may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Protriptyline may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Protriptyline may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Protriptyline may decrease the antihypertensive activities of Benazepril. |
| Bosentan | Protriptyline may decrease the antihypertensive activities of Bosentan. |
| Enalapril | Protriptyline may decrease the antihypertensive activities of Enalapril. |
| Cyclothiazide | Protriptyline may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Protriptyline may decrease the antihypertensive activities of Candoxatril. |
| Eplerenone | Protriptyline may decrease the antihypertensive activities of Eplerenone. |
| Lisinopril | Protriptyline may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Protriptyline may decrease the antihypertensive activities of Nitroglycerin. |
| Hydroflumethiazide | Protriptyline may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Protriptyline may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Protriptyline may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Protriptyline may decrease the antihypertensive activities of Candesartan cilexetil. |
| Fenoldopam | Protriptyline may decrease the antihypertensive activities of Fenoldopam. |
| Tadalafil | Protriptyline may decrease the antihypertensive activities of Tadalafil. |
| Eprosartan | Protriptyline may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Protriptyline may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Protriptyline may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Protriptyline may decrease the antihypertensive activities of Telmisartan. |
| Trichlormethiazide | Protriptyline may decrease the antihypertensive activities of Trichlormethiazide. |
| Irbesartan | Protriptyline may decrease the antihypertensive activities of Irbesartan. |
| Deserpidine | Protriptyline may decrease the antihypertensive activities of Deserpidine. |
| Diazoxide | Protriptyline may decrease the antihypertensive activities of Diazoxide. |
| Terazosin | Protriptyline may decrease the antihypertensive activities of Terazosin. |
| Guanethidine | Protriptyline may decrease the antihypertensive activities of Guanethidine. |
| Epoprostenol | Protriptyline may decrease the antihypertensive activities of Epoprostenol. |
| Hydralazine | Protriptyline may decrease the antihypertensive activities of Hydralazine. |
| Polythiazide | Protriptyline may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Protriptyline may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Protriptyline may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Protriptyline may decrease the antihypertensive activities of Spirapril. |
| Dexpropranolol | Protriptyline may decrease the antihypertensive activities of Dexpropranolol. |
| Tienilic acid | Protriptyline may decrease the antihypertensive activities of Tienilic acid. |
| Sitaxentan | Protriptyline may decrease the antihypertensive activities of Sitaxentan. |
| Diethylnorspermine | Protriptyline may decrease the antihypertensive activities of Diethylnorspermine. |
| Pinacidil | Protriptyline may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Protriptyline may decrease the antihypertensive activities of Temocapril. |
| Riociguat | Protriptyline may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Protriptyline may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Protriptyline may decrease the antihypertensive activities of Aliskiren. |
| Trimazosin | Protriptyline may decrease the antihypertensive activities of Trimazosin. |
| Rauwolfia serpentina root | Protriptyline may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Protriptyline may decrease the antihypertensive activities of Enalaprilat. |
| Angiotensin 1-7 | Protriptyline may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Protriptyline may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Protriptyline may decrease the antihypertensive activities of BQ-123. |
| Dihydralazine | Protriptyline may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Protriptyline may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Protriptyline may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Protriptyline may decrease the antihypertensive activities of Delapril. |
| Vincamine | Protriptyline may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Protriptyline may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Protriptyline may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Protriptyline may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Protriptyline may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Protriptyline may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Protriptyline may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Protriptyline may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Protriptyline may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Protriptyline may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Protriptyline may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Protriptyline may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Protriptyline may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Protriptyline may decrease the antihypertensive activities of Candesartan. |
| Dexniguldipine | Protriptyline may decrease the antihypertensive activities of Dexniguldipine. |
| Tocopherylquinone | Protriptyline may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Protriptyline may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Protriptyline may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Protriptyline may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Protriptyline may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Protriptyline may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Protriptyline may decrease the antihypertensive activities of Furosemide. |
| Captopril | Protriptyline may decrease the antihypertensive activities of Captopril. |
| Prazosin | Protriptyline may decrease the antihypertensive activities of Prazosin. |
| Bisoprolol | Protriptyline may decrease the antihypertensive activities of Bisoprolol. |
| Ambrisentan | Protriptyline may decrease the antihypertensive activities of Ambrisentan. |
| Selexipag | Protriptyline may decrease the antihypertensive activities of Selexipag. |
| Atenolol | Protriptyline may decrease the antihypertensive activities of Atenolol. |
| Amlodipine | Protriptyline may decrease the antihypertensive activities of Amlodipine. |
| Doxazosin | Protriptyline may decrease the antihypertensive activities of Doxazosin. |
| Carvedilol | Protriptyline may decrease the antihypertensive activities of Carvedilol. |
| Nadolol | Protriptyline may decrease the antihypertensive activities of Nadolol. |
| Bevantolol | Protriptyline may decrease the antihypertensive activities of Bevantolol. |
| Practolol | Protriptyline may decrease the antihypertensive activities of Practolol. |
| Debrisoquine | Protriptyline may decrease the antihypertensive activities of Debrisoquine. |
| Landiolol | Protriptyline may decrease the antihypertensive activities of Landiolol. |
| Esatenolol | Protriptyline may decrease the antihypertensive activities of Esatenolol. |