Mild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)
In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Reserpine | Reserpine may decrease the excretion rate of Terfenadine which could result in a higher serum level. |
| Ursodeoxycholic acid | Ursodeoxycholic acid may decrease the excretion rate of Terfenadine which could result in a higher serum level. |
| Cholic Acid | Cholic Acid may decrease the excretion rate of Terfenadine which could result in a higher serum level. |
| Valinomycin | Valinomycin may decrease the excretion rate of Terfenadine which could result in a higher serum level. |
| Olmesartan | Olmesartan may decrease the excretion rate of Terfenadine which could result in a higher serum level. |
| Troglitazone | Troglitazone may decrease the excretion rate of Terfenadine which could result in a higher serum level. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Terfenadine. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Terfenadine. |
| Erythromycin | The serum concentration of Terfenadine can be increased when it is combined with Erythromycin. |
| Azithromycin | The serum concentration of Terfenadine can be increased when it is combined with Azithromycin. |
| Roxithromycin | The serum concentration of Terfenadine can be increased when it is combined with Roxithromycin. |
| Sirolimus | The serum concentration of Terfenadine can be increased when it is combined with Sirolimus. |
| Dirithromycin | The serum concentration of Terfenadine can be increased when it is combined with Dirithromycin. |
| Telithromycin | The serum concentration of Terfenadine can be increased when it is combined with Telithromycin. |
| Candicidin | The serum concentration of Terfenadine can be increased when it is combined with Candicidin. |
| Clarithromycin | The serum concentration of Terfenadine can be increased when it is combined with Clarithromycin. |
| Josamycin | The serum concentration of Terfenadine can be increased when it is combined with Josamycin. |
| Everolimus | The serum concentration of Terfenadine can be increased when it is combined with Everolimus. |
| Epothilone D | The serum concentration of Terfenadine can be increased when it is combined with Epothilone D. |
| Patupilone | The serum concentration of Terfenadine can be increased when it is combined with Patupilone. |
| 6-Deoxyerythronolide B | The serum concentration of Terfenadine can be increased when it is combined with 6-Deoxyerythronolide B. |
| Ixabepilone | The serum concentration of Terfenadine can be increased when it is combined with Ixabepilone. |
| KOS-1584 | The serum concentration of Terfenadine can be increased when it is combined with KOS-1584. |
| Spiramycin | The serum concentration of Terfenadine can be increased when it is combined with Spiramycin. |
| Ridaforolimus | The serum concentration of Terfenadine can be increased when it is combined with Ridaforolimus. |
| Temsirolimus | The serum concentration of Terfenadine can be increased when it is combined with Temsirolimus. |
| AVE9633 | The serum concentration of Terfenadine can be increased when it is combined with AVE9633. |
| Coltuximab ravtansine | The serum concentration of Terfenadine can be increased when it is combined with Coltuximab ravtansine. |
| Cethromycin | The serum concentration of Terfenadine can be increased when it is combined with Cethromycin. |
| Mitemcinal | The serum concentration of Terfenadine can be increased when it is combined with Mitemcinal. |
| Brefeldin A | The serum concentration of Terfenadine can be increased when it is combined with Brefeldin A. |
| Solithromycin | The serum concentration of Terfenadine can be increased when it is combined with Solithromycin. |
| Kitasamycin | The serum concentration of Terfenadine can be increased when it is combined with Kitasamycin. |
| Carbomycin | The serum concentration of Terfenadine can be increased when it is combined with Carbomycin. |
| Doramectin | The serum concentration of Terfenadine can be increased when it is combined with Doramectin. |
| Eprinomectin | The serum concentration of Terfenadine can be increased when it is combined with Eprinomectin. |
| Oleandomycin | The serum concentration of Terfenadine can be increased when it is combined with Oleandomycin. |
| Selamectin | The serum concentration of Terfenadine can be increased when it is combined with Selamectin. |
| Tildipirosin | The serum concentration of Terfenadine can be increased when it is combined with Tildipirosin. |
| Tilmicosin | The serum concentration of Terfenadine can be increased when it is combined with Tilmicosin. |
| Tylosin | The serum concentration of Terfenadine can be increased when it is combined with Tylosin. |
| Tylvalosin | The serum concentration of Terfenadine can be increased when it is combined with Tylvalosin. |
| Bryostatin 1 | The serum concentration of Terfenadine can be increased when it is combined with Bryostatin 1. |
| Lorvotuzumab mertansine | The serum concentration of Terfenadine can be increased when it is combined with Lorvotuzumab mertansine. |
| Epofolate | The serum concentration of Terfenadine can be increased when it is combined with Epofolate. |
| Sagopilone | The serum concentration of Terfenadine can be increased when it is combined with Sagopilone. |
| Mirvetuximab soravtansine | The serum concentration of Mirvetuximab Soravtansine can be increased when it is combined with Terfenadine. |
| Troleandomycin | The serum concentration of Terfenadine can be increased when it is combined with Troleandomycin. |
| Miocamycin | The serum concentration of Terfenadine can be increased when it is combined with Miocamycin. |
| Flurithromycin | The serum concentration of Terfenadine can be increased when it is combined with Flurithromycin. |
| Rokitamycin | The serum concentration of Terfenadine can be increased when it is combined with Rokitamycin. |
| Midecamycin | The serum concentration of Terfenadine can be increased when it is combined with Midecamycin. |
| Mepartricin | The serum concentration of Terfenadine can be increased when it is combined with Mepartricin. |
| Aclidinium | The risk or severity of adverse effects can be increased when Terfenadine is combined with Aclidinium. |
| Mianserin | Mianserin may increase the anticholinergic activities of Terfenadine. |
| Mirabegron | The risk or severity of urinary retention can be increased when Terfenadine is combined with Mirabegron. |
| Potassium chloride | The risk or severity of gastrointestinal ulceration can be increased when Terfenadine is combined with Potassium chloride. |
| Pramlintide | The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Terfenadine. |
| Secretin porcine | The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Terfenadine. |
| Tiotropium | The risk or severity of adverse effects can be increased when Terfenadine is combined with Tiotropium. |
| Topiramate | The risk or severity of hyperthermia and oligohydrosis can be increased when Terfenadine is combined with Topiramate. |
| Umeclidinium | The risk or severity of adverse effects can be increased when Terfenadine is combined with Umeclidinium. |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with Terfenadine. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Terfenadine. |
| Fentanyl | The metabolism of Fentanyl can be decreased when combined with Terfenadine. |
| Iloperidone | The risk or severity of QTc prolongation can be increased when Terfenadine is combined with Iloperidone. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Terfenadine. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Terfenadine. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Terfenadine. |
| Benzylpenicilloyl polylysine | Terfenadine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent. |
| Betahistine | The therapeutic efficacy of Betahistine can be decreased when used in combination with Terfenadine. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Terfenadine. |
| Atomoxetine | The metabolism of Atomoxetine can be decreased when combined with Terfenadine. |
| Glycopyrronium | The risk or severity of adverse effects can be increased when Terfenadine is combined with Glycopyrronium. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Terfenadine. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Terfenadine. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Terfenadine. |
| Delavirdine | The metabolism of Terfenadine can be decreased when combined with Delavirdine. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Terfenadine. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Terfenadine. |
| Bicalutamide | The serum concentration of Terfenadine can be increased when it is combined with Bicalutamide. |
| Posaconazole | The risk or severity of QTc prolongation can be increased when Posaconazole is combined with Terfenadine. |
| Botulinum toxin type A | The risk or severity of adverse effects can be increased when Terfenadine is combined with Botulinum toxin type A. |
| Glucagon | Terfenadine may increase the gastrointestinal motility reducing activities of Glucagon. |
| Sulpiride | Terfenadine may increase the anticholinergic activities of Sulpiride. |
| Botulinum toxin type B | The risk or severity of adverse effects can be increased when Terfenadine is combined with Botulinum toxin type B. |
| Eluxadoline | The risk or severity of constipation can be increased when Terfenadine is combined with Eluxadoline. |
| Ramosetron | The risk or severity of constipation can be increased when Terfenadine is combined with Ramosetron. |
| Amphetamine | Amphetamine may decrease the sedative activities of Terfenadine. |
| Pseudoephedrine | Pseudoephedrine may decrease the sedative activities of Terfenadine. |
| Diethylpropion | Diethylpropion may decrease the sedative activities of Terfenadine. |
| Lisdexamfetamine | The serum concentration of dextroamphetamine, an active metabolite of Lisdexamfetamine, can be increased when used in combination with Terfenadine. |
| Mephentermine | Mephentermine may decrease the sedative activities of Terfenadine. |
| MMDA | MMDA may decrease the sedative activities of Terfenadine. |
| Midomafetamine | Midomafetamine may decrease the sedative activities of Terfenadine. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Terfenadine. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Terfenadine. |
| Tenamfetamine | Tenamfetamine may decrease the sedative activities of Terfenadine. |
| Chlorphentermine | Chlorphentermine may decrease the sedative activities of Terfenadine. |
| Methylenedioxyethamphetamine | Methylenedioxyethamphetamine may decrease the sedative activities of Terfenadine. |