Peringatan Keamanan

Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous mean lethal doses (LD50) of nitroprusside in rabbits, dogs, mice, and rats are 2.8, 5.0, 8.4, and 11.2 mg/kg, respectively.

Nitroprusside

DB00325

small molecule approved investigational

Deskripsi

Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.

Struktur Molekul 2D

Berat 215.938
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 2 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Metabolized by reaction with hemoglobin to produce cyanmethemoglobin and cynide ions

Rute Eliminasi

One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN¯ ions, thiosulfate reacts with cyanide to produce thiocyanate, thiocyanate is eliminated in the urine.

Interaksi Obat

1251 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Nitroprusside is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Nitroprusside is combined with Levodopa.
Risperidone Nitroprusside may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Nitroprusside.
Amifostine Nitroprusside may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Nitroprusside.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Nitroprusside.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Nitroprusside.
Obinutuzumab Nitroprusside may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Nitroprusside.
Rituximab Nitroprusside may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Nitroprusside.
Midodrine Midodrine may decrease the antihypertensive activities of Nitroprusside.
Eletriptan Eletriptan may decrease the antihypertensive activities of Nitroprusside.
Isoetharine Isoetharine may decrease the antihypertensive activities of Nitroprusside.
Methysergide Methysergide may decrease the antihypertensive activities of Nitroprusside.
Cabergoline Cabergoline may decrease the antihypertensive activities of Nitroprusside.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Nitroprusside.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Nitroprusside.
Protriptyline Protriptyline may decrease the antihypertensive activities of Nitroprusside.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Nitroprusside.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Nitroprusside.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Nitroprusside.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Nitroprusside.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Nitroprusside.
Promazine Promazine may decrease the antihypertensive activities of Nitroprusside.
Droperidol Droperidol may decrease the antihypertensive activities of Nitroprusside.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Nitroprusside.
Amoxapine Amoxapine may decrease the antihypertensive activities of Nitroprusside.
Doxapram Doxapram may decrease the antihypertensive activities of Nitroprusside.
Atropine Atropine may decrease the antihypertensive activities of Nitroprusside.
Lisuride Lisuride may decrease the antihypertensive activities of Nitroprusside.
Metaraminol Metaraminol may decrease the antihypertensive activities of Nitroprusside.
Trazodone Trazodone may decrease the antihypertensive activities of Nitroprusside.
Epinephrine Epinephrine may decrease the antihypertensive activities of Nitroprusside.
Ergotamine Ergotamine may decrease the antihypertensive activities of Nitroprusside.
Nicergoline Nicergoline may decrease the antihypertensive activities of Nitroprusside.
Methoxamine Methoxamine may decrease the antihypertensive activities of Nitroprusside.
Trimipramine Trimipramine may decrease the antihypertensive activities of Nitroprusside.
Propiomazine Propiomazine may decrease the antihypertensive activities of Nitroprusside.
Alfentanil Alfentanil may decrease the antihypertensive activities of Nitroprusside.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Nitroprusside.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Nitroprusside.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Nitroprusside.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Nitroprusside.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Nitroprusside.
Ritodrine Ritodrine may decrease the antihypertensive activities of Nitroprusside.
Flupentixol Flupentixol may decrease the antihypertensive activities of Nitroprusside.
Bitolterol Bitolterol may decrease the antihypertensive activities of Nitroprusside.
Oxymetazoline Oxymetazoline may decrease the antihypertensive activities of Nitroprusside.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Nitroprusside.
Salmeterol Salmeterol may decrease the antihypertensive activities of Nitroprusside.
Naratriptan Naratriptan may decrease the antihypertensive activities of Nitroprusside.
Formoterol Formoterol may decrease the antihypertensive activities of Nitroprusside.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Nitroprusside.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Nitroprusside.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Nitroprusside.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Nitroprusside.
Arbutamine Arbutamine may decrease the antihypertensive activities of Nitroprusside.
Dutasteride Dutasteride may decrease the antihypertensive activities of Nitroprusside.
Propafenone Propafenone may decrease the antihypertensive activities of Nitroprusside.
Pergolide Pergolide may decrease the antihypertensive activities of Nitroprusside.
Finasteride Finasteride may decrease the antihypertensive activities of Nitroprusside.
Ergometrine Ergometrine may decrease the antihypertensive activities of Nitroprusside.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Nitroprusside.
Fenoterol Fenoterol may decrease the antihypertensive activities of Nitroprusside.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Nitroprusside.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Nitroprusside.
Ephedrine Ephedrine may decrease the antihypertensive activities of Nitroprusside.
Mephentermine Mephentermine may decrease the antihypertensive activities of Nitroprusside.
Procaterol Procaterol may decrease the antihypertensive activities of Nitroprusside.
Yohimbine Yohimbine may decrease the antihypertensive activities of Nitroprusside.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Nitroprusside.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Nitroprusside.
Bambuterol Bambuterol may decrease the antihypertensive activities of Nitroprusside.
MMDA MMDA may decrease the antihypertensive activities of Nitroprusside.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Nitroprusside.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Nitroprusside.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Nitroprusside.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Nitroprusside.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Nitroprusside.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Nitroprusside.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Nitroprusside.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Nitroprusside.
Solifenacin Solifenacin may decrease the antihypertensive activities of Nitroprusside.
Periciazine Periciazine may decrease the antihypertensive activities of Nitroprusside.
Acepromazine Acepromazine may decrease the antihypertensive activities of Nitroprusside.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Nitroprusside.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Nitroprusside.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Nitroprusside.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Nitroprusside.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Nitroprusside.
Amineptine Amineptine may decrease the antihypertensive activities of Nitroprusside.
Dronedarone Dronedarone may decrease the antihypertensive activities of Nitroprusside.
Flibanserin Flibanserin may decrease the antihypertensive activities of Nitroprusside.
Iloperidone Iloperidone may decrease the antihypertensive activities of Nitroprusside.
Indacaterol Indacaterol may decrease the antihypertensive activities of Nitroprusside.
Amibegron Amibegron may decrease the antihypertensive activities of Nitroprusside.
Naluzotan Naluzotan may decrease the antihypertensive activities of Nitroprusside.
Cariprazine Cariprazine may decrease the antihypertensive activities of Nitroprusside.

Target Protein

Guanylate cyclase soluble subunit alpha-1 GUCY1A1
Guanylate cyclase soluble subunit beta-1 GUCY1B1
Atrial natriuretic peptide receptor 1 NPR1

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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