Peringatan Keamanan

Side effects may include acute anterior uveitis and perforation of the globe. Keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation and ptosis have occasionally been reported following local use of corticosteroids. LD50 = 234 mg/kg (rats)

Fluorometholone

DB00324

small molecule approved investigational

Deskripsi

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)

Struktur Molekul 2D

Berat 376.4617
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

845 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Fluorometholone.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Fluorometholone.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Fluorometholone.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Fluorometholone.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Fluorometholone.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Fluorometholone.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Fluorometholone.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Fluorometholone.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Fluorometholone.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Fluorometholone.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Fluorometholone.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Fluorometholone.
Pegaspargase The serum concentration of Fluorometholone can be increased when it is combined with Pegaspargase.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Fluorometholone.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Fluorometholone.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Fluorometholone.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Fluorometholone.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Fluorometholone.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Fluorometholone.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Fluorometholone.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Fluorometholone.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Fluorometholone.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Fluorometholone.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Fluorometholone.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Fluorometholone.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Fluorometholone.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Fluorometholone.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Fluorometholone.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Fluorometholone.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Fluorometholone.
Cladribine Fluorometholone may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Fluorometholone.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Fluorometholone.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluorometholone.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Fluorometholone.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Fluorometholone.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Fluorometholone.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Fluorometholone.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Fluorometholone.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Fluorometholone.
Tioguanine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Fluorometholone is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Fluorometholone is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Fluorometholone is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Fluorometholone is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Fluorometholone is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Fluorometholone is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Zidovudine.
Oxaliplatin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Fluorometholone is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorometholone is combined with Fluorouracil.
Desoximetasone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Desoximetasone.
Propylthiouracil The risk or severity of adverse effects can be increased when Fluorometholone is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Fluorometholone is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Fluorometholone is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Fluorometholone is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Fluorometholone is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Fluorometholone is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Fluorometholone is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Fluorometholone is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Fluorometholone is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Fluorometholone is combined with Methimazole.
Mometasone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Mometasone.
Etoposide The risk or severity of adverse effects can be increased when Fluorometholone is combined with Etoposide.
Dacarbazine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Fluorometholone is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Fluorometholone is combined with Sirolimus.
Azacitidine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Fluorometholone is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Fluorometholone is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Fluorometholone is combined with Busulfan.
Clobetasol propionate The risk or severity of adverse effects can be increased when Fluorometholone is combined with Clobetasol propionate.
Mycophenolic acid The risk or severity of adverse effects can be increased when Fluorometholone is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Fluorometholone is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Fluorometholone is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Fluorometholone is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Fluorometholone is combined with Melphalan.

Target Protein

Glucocorticoid receptor NR3C1

Referensi & Sumber

Synthesis reference: Fried, J.; U.S. Patent 2,852,51 September 16,1958; assigned to Olin Mathieson Chemical Corporation. ?Lincoln, F.H. Jr., Schneider, W.P. and Spero, G.B.; US. Patent 2,867,637; January 6, 1959; assigned to The Upjohn Company?. Lincoln, F.H. Jr., Schneider, W.P. and Spero, G.B.; U.S. Patent 2,867,638; January 6, 1959; assigned to The Upjohn Company. ?Magerlein, B.J., Kagan, F. and Schlagel, C.A.; U.S. Patent 3,038,914; June 12, 1962; assigned to The Upjohn Company.

Contoh Produk & Brand

Produk: 19 • International brands: 11
Produk
  • Flarex
    Suspension / drops • 1 mg/1mL • Ophthalmic • US • Approved
  • Flarex
    Suspension / drops • 1 mg/1mL • Ophthalmic • US • Approved
  • Flarex
    Suspension • 0.1 % w/v • Ophthalmic • Canada • Approved
  • Fluor-Op
    Suspension • 0.1 mL/100mL • Ophthalmic • US • Approved
  • Fluorometholone
    Solution / drops • 1 mg/1mL • Ophthalmic • US • Generic • Approved
  • Fluorometholone
    Solution / drops • 1 mg/1mL • Ophthalmic • US • Generic • Approved
  • Fluorometholone Ophthalmic Suspension
    Suspension / drops • 1 mg/1mL • Ophthalmic • US • Generic • Approved
  • Fluorometholone Ophthalmic Suspension
    Suspension / drops • 1 mg/1mL • Ophthalmic • US • Generic • Approved
Menampilkan 8 dari 19 produk.
International Brands
  • Efflumidex — Allergan
  • Fluaton — Allergan
  • Flumetholon — Ferron
  • Flurolon — Allergan
  • FML Liquifilm — Allergan
  • Foxone — Winston
  • Fucin — Mey See
  • Fuluson — Dae Wo
  • Fumelon — Han Lim
  • Humetoron — Kuk Je

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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