Peringatan Keamanan

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Floxuridine

DB00322

small molecule approved

Deskripsi

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Struktur Molekul 2D

Berat 246.1924
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic.

Rute Eliminasi

Floxuridine can be excreted as unchanged drug, urea, fluorouracil, a-fluoro-bureidopropionic acid, dihydrofluorouracil, a-fluoro-b-guanidopropionic acid and a-fluoro-b-alanine via the kidneys. Floxuridine may also be excreted as respiratory carbon dioxide.

Interaksi Obat

1292 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Floxuridine.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Floxuridine.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Floxuridine.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Floxuridine.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Floxuridine.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Floxuridine.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Floxuridine.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Floxuridine.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Floxuridine.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Floxuridine.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Floxuridine.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Floxuridine.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Floxuridine.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Floxuridine.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Floxuridine.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Floxuridine.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Floxuridine.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Floxuridine.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Floxuridine.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Floxuridine.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Floxuridine.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Floxuridine.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Floxuridine.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Floxuridine.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Floxuridine.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Floxuridine.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Floxuridine.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Floxuridine.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Floxuridine.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Floxuridine.
Cladribine Floxuridine may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Floxuridine.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Floxuridine.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Floxuridine.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Floxuridine.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Floxuridine.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Floxuridine.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Floxuridine.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Floxuridine.
Tioguanine The risk or severity of adverse effects can be increased when Floxuridine is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Floxuridine is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Floxuridine is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Floxuridine is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Floxuridine is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Floxuridine is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Floxuridine is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Floxuridine is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Floxuridine is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Floxuridine is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Floxuridine is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Floxuridine is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Floxuridine is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Floxuridine is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Floxuridine is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Floxuridine is combined with Oxaliplatin.
Vincristine The risk or severity of adverse effects can be increased when Floxuridine is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Floxuridine is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Floxuridine is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Floxuridine is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Floxuridine is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Floxuridine is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Floxuridine is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Floxuridine is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Floxuridine is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Floxuridine is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Floxuridine is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Floxuridine is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Floxuridine is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Floxuridine is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Floxuridine is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Floxuridine is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Floxuridine is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Floxuridine is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Floxuridine is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Floxuridine is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Floxuridine is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Floxuridine is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Floxuridine is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Floxuridine is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Floxuridine is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Floxuridine is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Floxuridine is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Floxuridine is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Floxuridine is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Floxuridine is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Floxuridine is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Floxuridine is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Floxuridine is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Floxuridine is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Floxuridine is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Floxuridine is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Floxuridine is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Floxuridine is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Floxuridine is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Floxuridine is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Floxuridine is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Floxuridine is combined with Melphalan.
Fludarabine The risk or severity of adverse effects can be increased when Floxuridine is combined with Fludarabine.
Flucytosine The risk or severity of adverse effects can be increased when Floxuridine is combined with Flucytosine.

Target Protein

Thymidylate synthase TMP1
Thymidylate synthase TYMS

Referensi & Sumber

Synthesis reference: U.S. Patent 3,041,335.

Contoh Produk & Brand

Produk: 5 • International brands: 1
Produk
  • Fdur
    Injection, powder, lyophilized, for solution • 500 mg/5mL • Intra-arterial • US • Approved
  • Floxuridine
    Injection, powder, lyophilized, for solution • 100 mg/1mL • Intra-arterial • US • Generic • Approved
  • Floxuridine
    Injection, powder, lyophilized, for solution • 100 mg/1mL • Intra-arterial • US • Generic • Approved
  • Floxuridine
    Injection, powder, lyophilized, for solution • 500 mg/5mL • Intra-arterial • US • Generic • Approved
  • Floxuridine
    Injection, powder, lyophilized, for solution • 500 mg/1 • Intra-arterial • US • Generic • Approved
International Brands
  • FUDR — Mayne

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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