Piperacillin

DB00319

small molecule approved

Deskripsi

Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics.

Struktur Molekul 2D

Berat 517.555
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 36-72 minutes
Volume Distribusi * 101 mL/kg [intravenous administration of 50 mg/kg (5-minute infusion) in neonates]
Klirens (Clearance) * 32 - 41 mL/min/1.73 m2 * 124 - 160 mL/min/1.73 m2 [older pediatric patients]

Absorpsi

Not absorbed following oral administration.

Metabolisme

Largely not metabolized.

Rute Eliminasi

As with other penicillins, PIPRACIL is eliminated primarily by glomerular filtration and tubular secretion; it is excreted rapidly as unchanged drug in high concentrations in the urine. Because PIPRACIL is excreted by the biliary route as well as by the renal route, it can be used safely in appropriate dosage in patients with severely restricted kidney function.

Interaksi Obat

952 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Piperacillin.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Piperacillin.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Piperacillin.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Piperacillin.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Piperacillin.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Piperacillin.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Piperacillin.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Piperacillin.
Cisatracurium Piperacillin may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Piperacillin.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Piperacillin.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Piperacillin.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Piperacillin.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Piperacillin.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Piperacillin.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Piperacillin.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Piperacillin.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Piperacillin.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Piperacillin.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Piperacillin.
Methotrexate The excretion of Methotrexate can be decreased when combined with Piperacillin.
Probenecid The excretion of Piperacillin can be decreased when combined with Probenecid.
Vancomycin Piperacillin may increase the nephrotoxic activities of Vancomycin.
Doxycycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Piperacillin can be decreased when used in combination with Penimepicycline.
Aspartame The excretion of Piperacillin can be decreased when combined with Aspartame.
Pravastatin The excretion of Piperacillin can be decreased when combined with Pravastatin.
Valproic acid The excretion of Piperacillin can be decreased when combined with Valproic acid.
Aminohippuric acid The excretion of Piperacillin can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Piperacillin can be decreased when combined with Lansoprazole.
Zidovudine The excretion of Piperacillin can be decreased when combined with Zidovudine.
Guanidine The excretion of Piperacillin can be decreased when combined with Guanidine.
Enalapril The excretion of Piperacillin can be decreased when combined with Enalapril.
Leucovorin The excretion of Piperacillin can be decreased when combined with Leucovorin.
Esomeprazole The excretion of Piperacillin can be decreased when combined with Esomeprazole.
Dinoprostone The excretion of Piperacillin can be decreased when combined with Dinoprostone.
Famotidine The excretion of Piperacillin can be decreased when combined with Famotidine.
Mercaptopurine The excretion of Piperacillin can be decreased when combined with Mercaptopurine.
Novobiocin The excretion of Piperacillin can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Piperacillin can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Piperacillin can be decreased when combined with Melatonin.
Ouabain The excretion of Piperacillin can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Piperacillin can be decreased when combined with Rosuvastatin.
Liotrix The excretion of Piperacillin can be decreased when combined with Liotrix.
Cilastatin The excretion of Piperacillin can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Piperacillin can be decreased when combined with trans-2-hydroxycinnamic acid.
Cholic Acid The excretion of Piperacillin can be decreased when combined with Cholic Acid.
Glutaric Acid The excretion of Piperacillin can be decreased when combined with Glutaric Acid.
Benzoic acid The excretion of Piperacillin can be decreased when combined with Benzoic acid.
Taurocholic acid The excretion of Piperacillin can be decreased when combined with Taurocholic acid.
Caprylic acid The excretion of Piperacillin can be decreased when combined with Caprylic acid.
Ataluren The excretion of Piperacillin can be decreased when combined with Ataluren.
Teriflunomide The excretion of Piperacillin can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Piperacillin can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Piperacillin can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Piperacillin can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Piperacillin can be decreased when combined with Cabotegravir.
Pradigastat The excretion of Piperacillin can be decreased when combined with Pradigastat.
Enasidenib The excretion of Piperacillin can be decreased when combined with Enasidenib.
Cefotiam The excretion of Piperacillin can be decreased when combined with Cefotiam.
Indomethacin The excretion of Piperacillin can be decreased when combined with Indomethacin.
Cefalotin The excretion of Piperacillin can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Piperacillin can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Piperacillin can be decreased when combined with Cefotaxime.
Piroxicam The excretion of Piperacillin can be decreased when combined with Piroxicam.
Cephalexin The excretion of Piperacillin can be decreased when combined with Cephalexin.
Diclofenac The excretion of Piperacillin can be decreased when combined with Diclofenac.
Acyclovir The excretion of Piperacillin can be decreased when combined with Acyclovir.
Phenylbutazone The excretion of Piperacillin can be decreased when combined with Phenylbutazone.
Cefaclor The excretion of Piperacillin can be decreased when combined with Cefaclor.
Salicylic acid The excretion of Piperacillin can be decreased when combined with Salicylic acid.
Acetylsalicylic acid The excretion of Piperacillin can be decreased when combined with Acetylsalicylic acid.
Ketoprofen The excretion of Piperacillin can be decreased when combined with Ketoprofen.
Ibuprofen The excretion of Piperacillin can be decreased when combined with Ibuprofen.
Cefadroxil The excretion of Piperacillin can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Piperacillin can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Piperacillin can be decreased when combined with Cefamandole.
Cefazolin The excretion of Piperacillin can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Piperacillin can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Piperacillin can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Piperacillin can be decreased when combined with Cefacetrile.
Ceftibuten The excretion of Piperacillin can be decreased when combined with Ceftibuten.
Cefaloridine The excretion of Piperacillin can be decreased when combined with Cefaloridine.
Pantoprazole The excretion of Piperacillin can be decreased when combined with Pantoprazole.
Liothyronine The excretion of Piperacillin can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Piperacillin can be decreased when combined with Conjugated estrogens.
Cimetidine The excretion of Piperacillin can be decreased when combined with Cimetidine.
Ganciclovir The excretion of Piperacillin can be decreased when combined with Ganciclovir.

Target Protein

Penicillin-binding protein 3 pbp3
Penicillin-binding protein 2B penA
Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 1b pbp1b

Referensi & Sumber

Synthesis reference: Bruce E. Haeger, "Composition of matter comprising a low bulk density lyophilized preparation of Sodium Piperacillin." U.S. Patent US4534977, issued October, 1984.
Artikel (PubMed)
  • PMID: 16940077
    Lau WK, Mercer D, Itani KM, Nicolau DP, Kuti JL, Mansfield D, Dana A: Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection. Antimicrob Agents Chemother. 2006 Nov;50(11):3556-61. Epub 2006 Aug 28.

Contoh Produk & Brand

Produk: 227 • International brands: 11
Produk
  • Jamp-pip/taz
    Powder, for solution • - • Intravenous • Canada • Generic • Approved
  • Piperacillin / Tazobactam Powder for Injection
    Powder, for solution • - • Intravenous • Canada • Approved
  • Piperacillin / Tazobactam Powder for Injection
    Powder, for solution • - • Intravenous • Canada • Approved
  • Piperacillin / Tazobactam Powder for Injection
    Powder, for solution • - • Intravenous • Canada • Approved
  • Piperacillin and Tazobactam
    Injection, powder, for solution • - • Intravenous • US • Generic • Approved
  • Piperacillin and Tazobactam
    Injection, powder, for solution • - • Intravenous • US • Generic • Approved
  • Piperacillin and Tazobactam
    Injection, powder, for solution • - • Intravenous • US • Generic • Approved
  • Piperacillin and Tazobactam
    Injection, powder, for solution • - • Intravenous • US • Generic • Approved
Menampilkan 8 dari 227 produk.
International Brands
  • Ecosette — Farmaceutici T.S.
  • Farecillin — SF Group
  • Penmalin — Sawai Seiyaku
  • Pentcillin — Toyama Kagaku
  • Peracin — Pharmadica
  • Piciliant — Shiono Kemikaru
  • Picillin — CT
  • Picillina — CCPC
  • Piperac — Klonal
  • Stepten — Aversi

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul