Peringatan Keamanan

Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD50) in mice was 514 mg/kg.

Capreomycin

DB00314

small molecule approved

Deskripsi

Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.

Struktur Molekul 2D

Berat 1321.4123
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

When a 1–g dose of capreomycin was given intramuscularly to normal volunteers, 52% was excreted in the urine within 12 hours.

Interaksi Obat

915 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Capreomycin.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Capreomycin.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Capreomycin.
Cisatracurium Capreomycin may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Capreomycin.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Capreomycin.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Capreomycin.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Capreomycin.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Capreomycin.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Capreomycin.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Capreomycin.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Capreomycin.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Capreomycin.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Capreomycin.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Capreomycin.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Capreomycin.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Capreomycin.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Capreomycin.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Capreomycin.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Capreomycin.
Carboplatin The risk or severity of ototoxicity and nephrotoxicity can be increased when Capreomycin is combined with Carboplatin.
Foscarnet The risk or severity of nephrotoxicity can be increased when Capreomycin is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Capreomycin.
Tenofovir disoproxil Capreomycin may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Capreomycin.
Tenofovir Capreomycin may increase the nephrotoxic activities of Tenofovir.
Zoledronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Capreomycin is combined with Zoledronic acid.
Alendronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Capreomycin is combined with Alendronic acid.
Ibandronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Capreomycin is combined with Ibandronate.
Clodronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Capreomycin is combined with Clodronic acid.
Risedronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Capreomycin is combined with Risedronic acid.
Etidronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Capreomycin is combined with Etidronic acid.
Incadronic acid The risk or severity of nephrotoxicity and hypocalcemia can be increased when Capreomycin is combined with Incadronic acid.
Taxifolin The risk or severity of nephrotoxicity can be increased when Taxifolin is combined with Capreomycin.
Licofelone The risk or severity of nephrotoxicity can be increased when Licofelone is combined with Capreomycin.
Polmacoxib The risk or severity of nephrotoxicity can be increased when Polmacoxib is combined with Capreomycin.
Ebselen The risk or severity of nephrotoxicity can be increased when Ebselen is combined with Capreomycin.
Flurbiprofen axetil The risk or severity of nephrotoxicity can be increased when Flurbiprofen axetil is combined with Capreomycin.
Acetyldigitoxin The risk or severity of adverse effects can be increased when Capreomycin is combined with Acetyldigitoxin.
Deslanoside The risk or severity of adverse effects can be increased when Capreomycin is combined with Deslanoside.
Ouabain The risk or severity of adverse effects can be increased when Capreomycin is combined with Ouabain.
Digitoxin The risk or severity of adverse effects can be increased when Capreomycin is combined with Digitoxin.
Oleandrin The risk or severity of adverse effects can be increased when Capreomycin is combined with Oleandrin.
Cymarin The risk or severity of adverse effects can be increased when Capreomycin is combined with Cymarin.
Proscillaridin The risk or severity of adverse effects can be increased when Capreomycin is combined with Proscillaridin.
Metildigoxin The risk or severity of adverse effects can be increased when Capreomycin is combined with Metildigoxin.
Lanatoside C The risk or severity of adverse effects can be increased when Capreomycin is combined with Lanatoside C.
Gitoformate The risk or severity of adverse effects can be increased when Capreomycin is combined with Gitoformate.
Acetyldigoxin The risk or severity of adverse effects can be increased when Capreomycin is combined with Acetyldigoxin.
Peruvoside The risk or severity of adverse effects can be increased when Capreomycin is combined with Peruvoside.
Torasemide The serum concentration of Capreomycin can be increased when it is combined with Torasemide.
Bumetanide The serum concentration of Capreomycin can be increased when it is combined with Bumetanide.
Etacrynic acid The serum concentration of Capreomycin can be increased when it is combined with Etacrynic acid.
Piretanide The serum concentration of Capreomycin can be increased when it is combined with Piretanide.
Azosemide The serum concentration of Capreomycin can be increased when it is combined with Azosemide.
Tripamide The serum concentration of Capreomycin can be increased when it is combined with Tripamide.
Flucloxacillin The serum concentration of Capreomycin can be decreased when it is combined with Flucloxacillin.
Phenoxymethylpenicillin The serum concentration of Capreomycin can be decreased when it is combined with Phenoxymethylpenicillin.
Dicloxacillin The serum concentration of Capreomycin can be decreased when it is combined with Dicloxacillin.
Carbenicillin The serum concentration of Capreomycin can be decreased when it is combined with Carbenicillin.
Nafcillin The serum concentration of Capreomycin can be decreased when it is combined with Nafcillin.
Hetacillin The serum concentration of Capreomycin can be decreased when it is combined with Hetacillin.
Benzylpenicilloyl polylysine The serum concentration of Capreomycin can be decreased when it is combined with Benzylpenicilloyl polylysine.
Mezlocillin The serum concentration of Capreomycin can be decreased when it is combined with Mezlocillin.
Cyclacillin The serum concentration of Capreomycin can be decreased when it is combined with Cyclacillin.
Benzylpenicillin The serum concentration of Capreomycin can be decreased when it is combined with Benzylpenicillin.
Azlocillin The serum concentration of Capreomycin can be decreased when it is combined with Azlocillin.
Cloxacillin The serum concentration of Capreomycin can be decreased when it is combined with Cloxacillin.
Amdinocillin The serum concentration of Capreomycin can be decreased when it is combined with Amdinocillin.
Bacampicillin The serum concentration of Capreomycin can be decreased when it is combined with Bacampicillin.
Meticillin The serum concentration of Capreomycin can be decreased when it is combined with Meticillin.
Pivampicillin The serum concentration of Capreomycin can be decreased when it is combined with Pivampicillin.
Pivmecillinam The serum concentration of Capreomycin can be decreased when it is combined with Pivmecillinam.
Ticarcillin The serum concentration of Capreomycin can be decreased when it is combined with Ticarcillin.
Azidocillin The serum concentration of Capreomycin can be decreased when it is combined with Azidocillin.
Carindacillin The serum concentration of Capreomycin can be decreased when it is combined with Carindacillin.
Sultamicillin The serum concentration of Capreomycin can be decreased when it is combined with Sultamicillin.
Temocillin The serum concentration of Capreomycin can be decreased when it is combined with Temocillin.
Epicillin The serum concentration of Capreomycin can be decreased when it is combined with Epicillin.
Pheneticillin The serum concentration of Capreomycin can be decreased when it is combined with Pheneticillin.
Carfecillin The serum concentration of Capreomycin can be decreased when it is combined with Carfecillin.
Propicillin The serum concentration of Capreomycin can be decreased when it is combined with Propicillin.
Clometocillin The serum concentration of Capreomycin can be decreased when it is combined with Clometocillin.
Sulbenicillin The serum concentration of Capreomycin can be decreased when it is combined with Sulbenicillin.
Penamecillin The serum concentration of Capreomycin can be decreased when it is combined with Penamecillin.
Talampicillin The serum concentration of Capreomycin can be decreased when it is combined with Talampicillin.
Aspoxicillin The serum concentration of Capreomycin can be decreased when it is combined with Aspoxicillin.
Metampicillin The serum concentration of Capreomycin can be decreased when it is combined with Metampicillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Capreomycin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Capreomycin.
Lymecycline The risk or severity of neuromuscular blockade can be increased when Lymecycline is combined with Capreomycin.
Clomocycline The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Clomocycline.
Quinine The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Quinine.
Tigecycline The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Tigecycline.
Oxytetracycline The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Oxytetracycline.
Demeclocycline The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Demeclocycline.
Magnesium sulfate The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Magnesium sulfate.
Metacycline The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Metacycline.
Minocycline The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Minocycline.
Clindamycin The risk or severity of neuromuscular blockade can be increased when Capreomycin is combined with Clindamycin.

Target Protein

16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA tlyA

Referensi & Sumber

Synthesis reference: Michael George Thomas, Elizabeth Anne Felnagle, Michelle Renee Rondon, Andrew David Berti, "Heterologous Production of Capreomycin and Generation of New Capreomycin Derivatives Through Metabolic Engineering." U.S. Patent US20090104658, issued April 23, 2009.

Contoh Produk & Brand

Produk: 4 • International brands: 5
Produk
  • Capastat Pws Im 1g Vial
    Powder, for solution • 1 g / vial • Intramuscular • Canada • Approved
  • Capastat sulfate
    Injection, powder, for solution • 1 g/2mL • Intramuscular; Intravenous • US • Approved
  • Capastat Sulfate
    Injection, powder, for solution • 1 g/1 • Intramuscular; Intravenous • US • Approved
  • Capreomycin Sulfate
    Injection, powder, for solution • 1 g/1 • Intramuscular; Intravenous • US • Generic • Approved
International Brands
  • Capastat — Akorn Incorporated
  • Capreomycin — Bristol-Myers Squibb
  • Helpomycin — Unifarm
  • Kapocin — Macleods
  • Lykocin — Lyka Labs Ltd.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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