Bexarotene

DB00307

small molecule approved investigational

Deskripsi

Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.

Struktur Molekul 2D

Berat 348.4779
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 7 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Urinary elimination of bexarotene and its known metabolites is a minor excretory pathway (<1% of administered dose).

Interaksi Makanan

1 Data
  • 1. Take with food.

Interaksi Obat

1044 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Bexarotene.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Bexarotene.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Bexarotene.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Bexarotene.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Bexarotene.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Bexarotene.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Bexarotene.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Bexarotene.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Bexarotene.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Bexarotene.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Bexarotene.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Bexarotene.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Bexarotene.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Bexarotene.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Bexarotene.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Bexarotene.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Bexarotene.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Bexarotene.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Bexarotene.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Bexarotene.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Bexarotene.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Bexarotene.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Bexarotene.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Bexarotene.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Bexarotene.
Cladribine Bexarotene may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Bexarotene.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Bexarotene.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Bexarotene.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Bexarotene.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Bexarotene.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Bexarotene.
Floxuridine The risk or severity of adverse effects can be increased when Bexarotene is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Bexarotene is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Bexarotene is combined with Tioguanine.
Dexrazoxane The risk or severity of adverse effects can be increased when Bexarotene is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Bexarotene is combined with Beclomethasone dipropionate.
Streptozocin The risk or severity of adverse effects can be increased when Bexarotene is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Bexarotene is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Bexarotene is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Bexarotene is combined with Betamethasone.
Epirubicin The risk or severity of adverse effects can be increased when Bexarotene is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Bexarotene is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Bexarotene is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Bexarotene is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Bexarotene is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Bexarotene is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Bexarotene is combined with Oxaliplatin.
Propylthiouracil The risk or severity of adverse effects can be increased when Bexarotene is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Bexarotene is combined with Pentostatin.
Fluticasone propionate The risk or severity of adverse effects can be increased when Bexarotene is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Bexarotene is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Bexarotene is combined with Linezolid.
Triamcinolone The risk or severity of adverse effects can be increased when Bexarotene is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Bexarotene is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Bexarotene is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Bexarotene is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Bexarotene is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Bexarotene is combined with Mycophenolate mofetil.
Sulfasalazine The risk or severity of adverse effects can be increased when Bexarotene is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Bexarotene is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Bexarotene is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Bexarotene is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Bexarotene is combined with Prednisolone.
Mechlorethamine The risk or severity of adverse effects can be increased when Bexarotene is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Bexarotene is combined with Azacitidine.
Methylprednisolone The risk or severity of adverse effects can be increased when Bexarotene is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Bexarotene is combined with Dactinomycin.
Azathioprine The risk or severity of adverse effects can be increased when Bexarotene is combined with Azathioprine.
Hydroxyurea The risk or severity of adverse effects can be increased when Bexarotene is combined with Hydroxyurea.
Mycophenolic acid The risk or severity of adverse effects can be increased when Bexarotene is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Bexarotene is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Bexarotene is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Bexarotene is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Bexarotene is combined with Melphalan.
Fludarabine The risk or severity of adverse effects can be increased when Bexarotene is combined with Fludarabine.
Flucytosine The risk or severity of adverse effects can be increased when Bexarotene is combined with Flucytosine.
Procarbazine The risk or severity of adverse effects can be increased when Bexarotene is combined with Procarbazine.
Arsenic trioxide The risk or severity of adverse effects can be increased when Bexarotene is combined with Arsenic trioxide.
Idarubicin The risk or severity of adverse effects can be increased when Bexarotene is combined with Idarubicin.
Estramustine The risk or severity of adverse effects can be increased when Bexarotene is combined with Estramustine.
Mitoxantrone The risk or severity of adverse effects can be increased when Bexarotene is combined with Mitoxantrone.
Lomustine The risk or severity of adverse effects can be increased when Bexarotene is combined with Lomustine.
Dexamethasone The risk or severity of adverse effects can be increased when Bexarotene is combined with Dexamethasone.
Eculizumab The risk or severity of adverse effects can be increased when Bexarotene is combined with Eculizumab.
Decitabine The risk or severity of adverse effects can be increased when Bexarotene is combined with Decitabine.
Nelarabine The risk or severity of adverse effects can be increased when Bexarotene is combined with Nelarabine.
Corticotropin The risk or severity of adverse effects can be increased when Bexarotene is combined with Corticotropin.
Cortisone acetate The risk or severity of adverse effects can be increased when Bexarotene is combined with Cortisone acetate.
Paramethasone The risk or severity of adverse effects can be increased when Bexarotene is combined with Paramethasone.
Ciclesonide The risk or severity of adverse effects can be increased when Bexarotene is combined with Ciclesonide.
Stepronin The risk or severity of adverse effects can be increased when Bexarotene is combined with Stepronin.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Bexarotene is combined with Hydroxychloroquine.
Castanospermine The risk or severity of adverse effects can be increased when Bexarotene is combined with Castanospermine.
Vorinostat The risk or severity of adverse effects can be increased when Bexarotene is combined with Vorinostat.
2-Methoxyethanol The risk or severity of adverse effects can be increased when Bexarotene is combined with 2-Methoxyethanol.
Brequinar The risk or severity of adverse effects can be increased when Bexarotene is combined with Brequinar.
Aldosterone The risk or severity of adverse effects can be increased when Bexarotene is combined with Aldosterone.
Pirfenidone The risk or severity of adverse effects can be increased when Bexarotene is combined with Pirfenidone.
Interferon alfa The risk or severity of adverse effects can be increased when Bexarotene is combined with Interferon alfa.

Target Protein

Retinoic acid receptor RXR-alpha RXRA
Retinoic acid receptor RXR-beta RXRB
Retinoic acid receptor RXR-gamma RXRG

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17553039
    Gniadecki R, Assaf C, Bagot M, Dummer R, Duvic M, Knobler R, Ranki A, Schwandt P, Whittaker S: The optimal use of bexarotene in cutaneous T-cell lymphoma. Br J Dermatol. 2007 Sep;157(3):433-40. Epub 2007 Jun 6.
  • PMID: 17363535
    Dragnev KH, Petty WJ, Shah SJ, Lewis LD, Black CC, Memoli V, Nugent WC, Hermann T, Negro-Vilar A, Rigas JR, Dmitrovsky E: A proof-of-principle clinical trial of bexarotene in patients with non-small cell lung cancer. Clin Cancer Res. 2007 Mar 15;13(6):1794-800.
  • PMID: 17440015
    Smit JW, Stokkel MP, Pereira AM, Romijn JA, Visser TJ: Bexarotene-induced hypothyroidism: bexarotene stimulates the peripheral metabolism of thyroid hormones. J Clin Endocrinol Metab. 2007 Jul;92(7):2496-9. Epub 2007 Apr 17.
  • PMID: 11702369
    Lowe MN, Plosker GL: Bexarotene. Am J Clin Dermatol. 2000 Jul-Aug;1(4):245-50; discussion 251-2.
  • PMID: 16495926
    Yen WC, Prudente RY, Corpuz MR, Negro-Vilar A, Lamph WW: A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours. Br J Cancer. 2006 Mar 13;94(5):654-60.
  • PMID: 15056048
    Farol LT, Hymes KB: Bexarotene: a clinical review. Expert Rev Anticancer Ther. 2004 Apr;4(2):180-8.

Contoh Produk & Brand

Produk: 20 • International brands: 0
Produk
  • Bexarotene
    Gel • 1 g/100g • Topical • US • Generic • Approved
  • Bexarotene
    Capsule • 75 mg/1 • Oral • US • Generic • Approved
  • Bexarotene
    Capsule, liquid filled • 75 mg/1 • Oral • US • Generic • Approved
  • Bexarotene
    Capsule • 75 mg/1 • Oral • US • Generic • Approved
  • Bexarotene
    Capsule, liquid filled • 75 mg/1 • Oral • US • Generic • Approved
  • Bexarotene
    Capsule, liquid filled • 75 mg/1 • Oral • US • Generic • Approved
  • Bexarotene
    Capsule, liquid filled • 75 mg/1 • Oral • US • Generic • Approved
  • Bexarotene
    Capsule, liquid filled • 75 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 20 produk.

Sekuens Gen/Protein (FASTA)

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