Flucloxacillin

DB00301

small molecule approved investigational

Deskripsi

Antibiotic analog of cloxacillin.

Struktur Molekul 2D

Berat 453.872
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 0.75–1 hour
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Bioavailability is 50–70% following oral administration.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach.

Interaksi Obat

423 Data
Troglitazone Troglitazone may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Erythromycin Erythromycin may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Reserpine Reserpine may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Progesterone Progesterone may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Chlorpromazine Chlorpromazine may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Cimetidine Cimetidine may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Bosentan Bosentan may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Ethinylestradiol Ethinylestradiol may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Glyburide Glyburide may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Ursodeoxycholic acid Ursodeoxycholic acid may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Cholic Acid Cholic Acid may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Fusidic acid Fusidic acid may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Simeprevir Simeprevir may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Lenvatinib Lenvatinib may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Valinomycin Valinomycin may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Ketoconazole Ketoconazole may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Nifedipine Flucloxacillin may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Olmesartan Olmesartan may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Tipranavir Tipranavir may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Pralsetinib Pralsetinib may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Flucloxacillin.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Flucloxacillin.
Methotrexate The excretion of Methotrexate can be decreased when combined with Flucloxacillin.
Probenecid The excretion of Flucloxacillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Penimepicycline.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Flucloxacillin.
Perampanel The metabolism of Perampanel can be increased when combined with Flucloxacillin.
Warfarin The metabolism of Warfarin can be increased when combined with Flucloxacillin.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Flucloxacillin.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Flucloxacillin.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Flucloxacillin.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Flucloxacillin.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Flucloxacillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Flucloxacillin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Flucloxacillin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Flucloxacillin.
Piperacillin The serum concentration of Flucloxacillin can be increased when it is combined with Piperacillin.
Dicoumarol Flucloxacillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Flucloxacillin may increase the anticoagulant activities of Phenindione.
Coumarin Flucloxacillin may increase the anticoagulant activities of Coumarin.
Tioclomarol Flucloxacillin may increase the anticoagulant activities of Tioclomarol.
Ethyl biscoumacetate Flucloxacillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Diphenadione Flucloxacillin may increase the anticoagulant activities of Diphenadione.
4-hydroxycoumarin Flucloxacillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Fluindione Flucloxacillin may increase the anticoagulant activities of Fluindione.
Clorindione Flucloxacillin may increase the anticoagulant activities of Clorindione.
Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Flucloxacillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Flucloxacillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Flucloxacillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Flucloxacillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Flucloxacillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Flucloxacillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Flucloxacillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Flucloxacillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Flucloxacillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Flucloxacillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Flucloxacillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Flucloxacillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Flucloxacillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Flucloxacillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Flucloxacillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Flucloxacillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Flucloxacillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Flucloxacillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Flucloxacillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Flucloxacillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Flucloxacillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Flucloxacillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Flucloxacillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Flucloxacillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Flucloxacillin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Flucloxacillin.
Acemetacin Acemetacin may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Deoxycholic acid Deoxycholic acid may increase the excretion rate of Flucloxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Taurocholic acid Taurocholic acid may increase the excretion rate of Flucloxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital Phenobarbital may increase the excretion rate of Flucloxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Dexamethasone Dexamethasone may increase the excretion rate of Flucloxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Dexamethasone acetate Dexamethasone acetate may increase the excretion rate of Flucloxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Pravastatin Pravastatin may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Glimepiride Glimepiride may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Indomethacin Flucloxacillin may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Atropine Flucloxacillin may decrease the excretion rate of Atropine which could result in a higher serum level.
Fluorescein Flucloxacillin may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Nitrofurantoin Flucloxacillin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Naproxen Flucloxacillin may decrease the excretion rate of Naproxen which could result in a higher serum level.
Cefaclor Flucloxacillin may decrease the excretion rate of Cefaclor which could result in a higher serum level.

Target Protein

Penicillin-binding protein 1A pbpA

Referensi & Sumber

Synthesis reference: Nayler, J.H.C.; U.S. Patent 3.239307; March 8,1966; assigned to Beecharn Group Limited, England.

Contoh Produk & Brand

Produk: 5 • International brands: 5
Produk
  • Fluclox 250
    Liquid • 250 mg / 5 mL • Oral • Canada • Approved
  • Fluclox 250 Cap 250mg
    Capsule • 250 mg / cap • Oral • Canada • Approved
  • Fluclox 500 Cap 500mg
    Capsule • 500 mg / cap • Oral • Canada • Approved
  • Fluclox-125 Pws 125mg/5ml
    Powder, for solution • 125 mg / 5 mL • Oral • Canada • Approved
  • Fluclox-250 Cap 250mg
    Capsule • 250 mg / cap • Oral • Canada • Approved
International Brands
  • Flopen — Aspen
  • Floxapen — GSK
  • Fluclox — ACI
  • Softapen
  • Staphylex — Actavis

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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