Peringatan Keamanan

Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.

Penciclovir

DB00299

small molecule approved

Deskripsi

Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue.

Struktur Molekul 2D

Berat 253.2578
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Measurable penciclovir concentrations were not detected in plasma or urine of healthy male volunteers (n= 12) following single or repeat application of the 1% cream at a dose of 180 mg penciclovir daily.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

325 Data
Deferasirox The serum concentration of Penciclovir can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Penciclovir can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Penciclovir can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Penciclovir can be decreased when it is combined with Teriflunomide.
Abiraterone The serum concentration of Penciclovir can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Penciclovir can be increased when combined with Cyproterone acetate.
Carbamazepine The metabolism of Penciclovir can be increased when combined with Carbamazepine.
Primidone The metabolism of Penciclovir can be increased when combined with Primidone.
Rifampin The metabolism of Penciclovir can be increased when combined with Rifampicin.
Albendazole The metabolism of Penciclovir can be increased when combined with Albendazole.
Caffeine The metabolism of Penciclovir can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Penciclovir can be decreased when combined with Moxifloxacin.
Lidocaine The metabolism of Penciclovir can be decreased when combined with Lidocaine.
Mexiletine The metabolism of Penciclovir can be decreased when combined with Mexiletine.
Imipramine The metabolism of Penciclovir can be decreased when combined with Imipramine.
Alosetron The metabolism of Penciclovir can be decreased when combined with Alosetron.
Ketoconazole The metabolism of Penciclovir can be decreased when combined with Ketoconazole.
Gatifloxacin The metabolism of Penciclovir can be decreased when combined with Gatifloxacin.
Simeprevir The metabolism of Penciclovir can be decreased when combined with Simeprevir.
Lobeglitazone The metabolism of Penciclovir can be decreased when combined with Lobeglitazone.
Pazufloxacin The metabolism of Penciclovir can be decreased when combined with Pazufloxacin.
Osilodrostat The metabolism of Penciclovir can be decreased when combined with Osilodrostat.
Osimertinib The serum concentration of Penciclovir can be decreased when it is combined with Osimertinib.
Vemurafenib The serum concentration of Penciclovir can be increased when it is combined with Vemurafenib.
Citalopram The metabolism of Penciclovir can be decreased when combined with Citalopram.
Nevirapine The metabolism of Penciclovir can be decreased when combined with Nevirapine.
Cimetidine The metabolism of Penciclovir can be decreased when combined with Cimetidine.
Trovafloxacin The metabolism of Penciclovir can be decreased when combined with Trovafloxacin.
Famotidine The metabolism of Penciclovir can be decreased when combined with Famotidine.
Viloxazine The metabolism of Penciclovir can be decreased when combined with Viloxazine.
Pipemidic acid The metabolism of Penciclovir can be decreased when combined with Pipemidic acid.
Ethambutol The metabolism of Penciclovir can be decreased when combined with Ethambutol.
Belinostat The metabolism of Penciclovir can be increased when combined with Belinostat.
Rucaparib The metabolism of Penciclovir can be increased when combined with Rucaparib.
Insulin pork The metabolism of Penciclovir can be increased when combined with Insulin pork.
Phenylephrine The metabolism of Penciclovir can be increased when combined with Phenylephrine.
Ritonavir The metabolism of Penciclovir can be increased when combined with Ritonavir.
Nafcillin The metabolism of Penciclovir can be increased when combined with Nafcillin.
Primaquine The metabolism of Penciclovir can be increased when combined with Primaquine.
Fosphenytoin The metabolism of Penciclovir can be increased when combined with Fosphenytoin.
NN344 The metabolism of Penciclovir can be increased when combined with NN344.
Dovitinib The metabolism of Penciclovir can be increased when combined with Dovitinib.
Armodafinil The metabolism of Penciclovir can be increased when combined with Armodafinil.
beta-Naphthoflavone The metabolism of Penciclovir can be increased when combined with beta-Naphthoflavone.
Capsaicin The metabolism of Penciclovir can be increased when combined with Capsaicin.
Insulin beef The metabolism of Penciclovir can be increased when combined with Insulin beef.
Insulin peglispro The metabolism of Penciclovir can be increased when combined with Insulin peglispro.
Insulin tregopil The metabolism of Penciclovir can be increased when combined with Insulin tregopil.
Pitolisant The metabolism of Penciclovir can be increased when combined with Pitolisant.
Somatotropin The metabolism of Penciclovir can be increased when combined with Somatotropin.
Somapacitan The metabolism of Penciclovir can be increased when combined with Somapacitan.
Peginterferon alfa-2a The metabolism of Penciclovir can be decreased when combined with Peginterferon alfa-2a.
Interferon alfa-n1 The metabolism of Penciclovir can be decreased when combined with Interferon alfa-n1.
Interferon alfa-n3 The metabolism of Penciclovir can be decreased when combined with Interferon alfa-n3.
Interferon gamma-1b The metabolism of Penciclovir can be decreased when combined with Interferon gamma-1b.
Interferon alfa-2a The metabolism of Penciclovir can be decreased when combined with Interferon alfa-2a.
Interferon beta-1a The metabolism of Penciclovir can be decreased when combined with Interferon beta-1a.
Interferon beta-1b The metabolism of Penciclovir can be decreased when combined with Interferon beta-1b.
Interferon alfacon-1 The metabolism of Penciclovir can be decreased when combined with Interferon alfacon-1.
Interferon alfa-2b The metabolism of Penciclovir can be decreased when combined with Interferon alfa-2b.
Ticlopidine The metabolism of Penciclovir can be decreased when combined with Ticlopidine.
Valproic acid The metabolism of Penciclovir can be decreased when combined with Valproic acid.
Grepafloxacin The metabolism of Penciclovir can be decreased when combined with Grepafloxacin.
Promazine The metabolism of Penciclovir can be decreased when combined with Promazine.
Fluoxetine The metabolism of Penciclovir can be decreased when combined with Fluoxetine.
Pefloxacin The metabolism of Penciclovir can be decreased when combined with Pefloxacin.
Methoxsalen The metabolism of Penciclovir can be decreased when combined with Methoxsalen.
Efavirenz The metabolism of Penciclovir can be decreased when combined with Efavirenz.
Dexmedetomidine The metabolism of Penciclovir can be decreased when combined with Dexmedetomidine.
Thiabendazole The metabolism of Penciclovir can be decreased when combined with Thiabendazole.
Methimazole The metabolism of Penciclovir can be decreased when combined with Methimazole.
Nalidixic acid The metabolism of Penciclovir can be decreased when combined with Nalidixic acid.
Rosoxacin The metabolism of Penciclovir can be decreased when combined with Rosoxacin.
Cinoxacin The metabolism of Penciclovir can be decreased when combined with Cinoxacin.
Isoniazid The metabolism of Penciclovir can be decreased when combined with Isoniazid.
Norfloxacin The metabolism of Penciclovir can be decreased when combined with Norfloxacin.
Tegaserod The metabolism of Penciclovir can be decreased when combined with Tegaserod.
Nifedipine The metabolism of Nifedipine can be decreased when combined with Penciclovir.
Gemifloxacin The metabolism of Penciclovir can be decreased when combined with Gemifloxacin.
Orphenadrine The metabolism of Penciclovir can be decreased when combined with Orphenadrine.
Propafenone The metabolism of Penciclovir can be decreased when combined with Propafenone.
Gemfibrozil The metabolism of Penciclovir can be decreased when combined with Gemfibrozil.
Mibefradil The metabolism of Penciclovir can be decreased when combined with Mibefradil.
Temafloxacin The metabolism of Penciclovir can be decreased when combined with Temafloxacin.
Estrone sulfate The metabolism of Penciclovir can be decreased when combined with Estrone sulfate.
Interferon alfa The metabolism of Penciclovir can be decreased when combined with Interferon alfa.
Albinterferon Alfa-2B The metabolism of Penciclovir can be decreased when combined with Albinterferon Alfa-2B.
Obeticholic acid The metabolism of Penciclovir can be decreased when combined with Obeticholic acid.
Garenoxacin The metabolism of Penciclovir can be decreased when combined with Garenoxacin.
Avasimibe The metabolism of Penciclovir can be decreased when combined with Avasimibe.
Nemonoxacin The metabolism of Penciclovir can be decreased when combined with Nemonoxacin.
Niclosamide The metabolism of Penciclovir can be decreased when combined with Niclosamide.
Flumequine The metabolism of Penciclovir can be decreased when combined with Flumequine.
Stiripentol The metabolism of Penciclovir can be increased when combined with Stiripentol.
Methylene blue The metabolism of Penciclovir can be increased when combined with Methylene blue.
Enrofloxacin The metabolism of Penciclovir can be decreased when combined with Enrofloxacin.
Orbifloxacin The metabolism of Penciclovir can be decreased when combined with Orbifloxacin.
Sarafloxacin The metabolism of Penciclovir can be decreased when combined with Sarafloxacin.
Difloxacin The metabolism of Penciclovir can be decreased when combined with Difloxacin.
Capmatinib The metabolism of Penciclovir can be decreased when combined with Capmatinib.

Target Protein

Thymidine kinase, cytosolic TK1
DNA polymerase catalytic subunit
Thymidine kinase TK

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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