Peringatan Keamanan

The reported LD50 of oral etonogestrel in the rat is reported to be higher than 2000 mg/kg.MSDS Overdosage can only happen when more than one implant is inserted. In cases of overdose, removal of the implant is recommended.FDA label

There aren't reports relating etonogestrel with carcinogenesis, mutagenesis or impaired fertility.FDA label

Etonogestrel

DB00294

small molecule approved investigational

Deskripsi

Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.A37184 The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.L5692

Struktur Molekul 2D

Berat 324.4565
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life of etonogestrel is reported to be of 25 hours which indicates a reversible contraceptive effect.[L5695]
Volume Distribusi The apparent volume of distribution of etonogestrel is of around 201 L.[A175993]
Klirens (Clearance) The clearance rate of etonogestrel is reported to be of 7.5 L/h.[A175993]

Absorpsi

Vaginal administration of etonogestrel is known to be significantly absorbed through the vaginal epithelium but it does not increase the levels of etonogestrel in the urine. On the other hand, oral administration is absorbed in the GI tract and it goes through the first-pass metabolism.A37184 When etonogestrel is administered subdermally it is absorbed rapidly into the bloodstream and it presents a bioavailability of 82%.T55 It is reported that the implant releases around 60 mcg per day in the first 3 months and then decreases steady reaching a concentration of 30 mcg at the end of year 2.A175993

Metabolisme

Etonogestrel is highly metabolized in the liver by the action of the cytochrome isoenzyme 3A4 mainly by the presence of hydroxylation, sulfate conjugation and glucuronide conjugation reactions.L5695

Rute Eliminasi

The elimination of etonogestrel and its metabolites is mainly done renally.L5695

Interaksi Makanan

5 Data
  • 1. Administer vitamin supplements.
  • 2. Avoid alcohol.
  • 3. Limit caffeine intake.
  • 4. Take at the same time every day.
  • 5. Take with food.

Interaksi Obat

1186 Data
Aprepitant The serum concentration of Etonogestrel can be decreased when it is combined with Aprepitant.
Efavirenz The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Efavirenz.
Exenatide Exenatide can cause a decrease in the absorption of Etonogestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Thalidomide Etonogestrel may increase the thrombogenic activities of Thalidomide.
Ulipristal The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Ulipristal.
Tranexamic acid Etonogestrel may increase the thrombogenic activities of Tranexamic acid.
Clobazam The serum concentration of Etonogestrel can be decreased when it is combined with Clobazam.
Griseofulvin The metabolism of Etonogestrel can be increased when combined with Griseofulvin.
Fluocortin The serum concentration of Fluocortin can be increased when it is combined with Etonogestrel.
Fluperolone The serum concentration of Fluperolone can be increased when it is combined with Etonogestrel.
Fluclorolone The serum concentration of Fluclorolone can be increased when it is combined with Etonogestrel.
Flunisolide The serum concentration of Flunisolide can be increased when it is combined with Etonogestrel.
Beclomethasone dipropionate The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Etonogestrel.
Betamethasone The serum concentration of Betamethasone can be increased when it is combined with Etonogestrel.
Fluocinolone acetonide The serum concentration of Fluocinolone acetonide can be increased when it is combined with Etonogestrel.
Triamcinolone The serum concentration of Triamcinolone can be increased when it is combined with Etonogestrel.
Prednisone The serum concentration of Prednisone can be increased when it is combined with Etonogestrel.
Hydrocortisone The serum concentration of Hydrocortisone can be increased when it is combined with Etonogestrel.
Prednisolone The serum concentration of Prednisolone can be increased when it is combined with Etonogestrel.
Methylprednisolone The serum concentration of Methylprednisolone can be increased when it is combined with Etonogestrel.
Corticotropin The serum concentration of Corticotropin can be increased when it is combined with Etonogestrel.
Cortisone acetate The serum concentration of Cortisone acetate can be increased when it is combined with Etonogestrel.
Fluprednidene The serum concentration of Fluprednidene can be increased when it is combined with Etonogestrel.
Meprednisone The serum concentration of Meprednisone can be increased when it is combined with Etonogestrel.
Dexamethasone isonicotinate The serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Etonogestrel.
Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Etonogestrel.
Cortivazol The serum concentration of Cortivazol can be increased when it is combined with Etonogestrel.
Prednylidene The serum concentration of Prednylidene can be increased when it is combined with Etonogestrel.
Cloprednol The serum concentration of Cloprednol can be increased when it is combined with Etonogestrel.
Mometasone furoate The serum concentration of Mometasone furoate can be increased when it is combined with Etonogestrel.
Hydrocortisone acetate The serum concentration of Hydrocortisone acetate can be increased when it is combined with Etonogestrel.
Hydrocortisone succinate The serum concentration of Hydrocortisone succinate can be increased when it is combined with Etonogestrel.
Prednisolone phosphate The serum concentration of Prednisolone phosphate can be increased when it is combined with Etonogestrel.
Prednisolone hemisuccinate The serum concentration of Prednisolone hemisuccinate can be increased when it is combined with Etonogestrel.
Methylprednisolone hemisuccinate The serum concentration of Methylprednisolone hemisuccinate can be increased when it is combined with Etonogestrel.
Prednisone acetate The serum concentration of Prednisone acetate can be increased when it is combined with Etonogestrel.
Clocortolone acetate The serum concentration of Clocortolone acetate can be increased when it is combined with Etonogestrel.
Melengestrol acetate The serum concentration of Melengestrol acetate can be increased when it is combined with Etonogestrel.
Betamethasone phosphate The serum concentration of Betamethasone phosphate can be increased when it is combined with Etonogestrel.
Cortisone The serum concentration of Cortisone can be increased when it is combined with Etonogestrel.
Tixocortol The serum concentration of Tixocortol can be increased when it is combined with Etonogestrel.
Fluticasone propionate The serum concentration of Fluticasone propionate can be increased when it is combined with Etonogestrel.
Fludrocortisone The serum concentration of Fludrocortisone can be increased when it is combined with Etonogestrel.
Trilostane The serum concentration of Trilostane can be increased when it is combined with Etonogestrel.
Budesonide The serum concentration of Budesonide can be increased when it is combined with Etonogestrel.
Dexamethasone The serum concentration of Dexamethasone can be increased when it is combined with Etonogestrel.
Paramethasone The serum concentration of Paramethasone can be increased when it is combined with Etonogestrel.
Ciclesonide The serum concentration of Ciclesonide can be increased when it is combined with Etonogestrel.
Aldosterone The serum concentration of Aldosterone can be increased when it is combined with Etonogestrel.
Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Etonogestrel.
Fluprednisolone The serum concentration of Fluprednisolone can be increased when it is combined with Etonogestrel.
Melengestrol The serum concentration of Melengestrol can be increased when it is combined with Etonogestrel.
Fluticasone The serum concentration of Fluticasone can be increased when it is combined with Etonogestrel.
Hydrocortisone cypionate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Etonogestrel.
Clobetasol propionate The serum concentration of Clobetasol propionate can be increased when it is combined with Etonogestrel.
Fluocinonide The serum concentration of Fluocinonide can be increased when it is combined with Etonogestrel.
Hydrocortisone butyrate The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Etonogestrel.
Desoximetasone The serum concentration of Desoximetasone can be increased when it is combined with Etonogestrel.
Mometasone The serum concentration of Mometasone can be increased when it is combined with Etonogestrel.
Fluocortolone The serum concentration of Fluocortolone can be increased when it is combined with Etonogestrel.
Prednisolone acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Etonogestrel.
Fluorometholone The serum concentration of Fluorometholone can be increased when it is combined with Etonogestrel.
Difluocortolone The serum concentration of Difluocortolone can be increased when it is combined with Etonogestrel.
Flumethasone The serum concentration of Flumethasone can be increased when it is combined with Etonogestrel.
Methylprednisolone aceponate The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Etonogestrel.
Bosentan The serum concentration of Etonogestrel can be decreased when it is combined with Bosentan.
Carbamazepine The serum concentration of Etonogestrel can be decreased when it is combined with Carbamazepine.
Phenoxymethylpenicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Phenoxymethylpenicillin.
Carbenicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Carbenicillin.
Hetacillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Hetacillin.
Benzylpenicilloyl polylysine The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Benzylpenicilloyl polylysine.
Mezlocillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Mezlocillin.
Cyclacillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Cyclacillin.
Benzylpenicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Benzylpenicillin.
Azlocillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Azlocillin.
Cloxacillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Cloxacillin.
Amdinocillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Amdinocillin.
Bacampicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Bacampicillin.
Meticillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Meticillin.
Pivampicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Pivampicillin.
Pivmecillinam The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Pivmecillinam.
Ticarcillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Ticarcillin.
Azidocillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Azidocillin.
Carindacillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Carindacillin.
Sultamicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Sultamicillin.
Temocillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Temocillin.
Epicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Epicillin.
Pheneticillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Pheneticillin.
Carfecillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Carfecillin.
Propicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Propicillin.
Clometocillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Clometocillin.
Sulbenicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Sulbenicillin.
Penamecillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Penamecillin.
Talampicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Talampicillin.
Aspoxicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Aspoxicillin.
Metampicillin The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Metampicillin.
Coumarin The therapeutic efficacy of Coumarin can be decreased when used in combination with Etonogestrel.
Semuloparin The therapeutic efficacy of Semuloparin can be decreased when used in combination with Etonogestrel.
Monteplase The therapeutic efficacy of Monteplase can be decreased when used in combination with Etonogestrel.
Dabigatran The therapeutic efficacy of Dabigatran can be decreased when used in combination with Etonogestrel.

Target Protein

Progesterone receptor PGR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26241255
    Gariepy AM, Duffy JY, Xu X: Cost-Effectiveness of Immediate Compared With Delayed Postpartum Etonogestrel Implant Insertion. Obstet Gynecol. 2015 Jul;126(1):47-55. doi: 10.1097/AOG.0000000000000907.
  • PMID: 18728840
    Roumen FJ: Review of the combined contraceptive vaginal ring, NuvaRing. Ther Clin Risk Manag. 2008 Apr;4(2):441-51.
  • PMID: 9883383
    Wenzl R, van Beek A, Schnabel P, Huber J: Pharmacokinetics of etonogestrel released from the contraceptive implant Implanon. Contraception. 1998 Nov;58(5):283-8.
Textbook
  • Feisullin K. and Westhoff C. (2010). Principles of gender-specific medicine (2nd ed.). Academic press.
  • Zaragoza Dorwald F. (2012). Lead optimization for medicinal chemists. Wiley-VCH.

Contoh Produk & Brand

Produk: 22 • International brands: 0
Produk
  • EluRyng
    Ring • - • Vaginal • US • Generic • Approved
  • EnilloRing
    Ring • - • Vaginal • US • Generic • Approved
  • Etonogestrel and Ethinyl Estradiol
    Insert, extended release • - • Vaginal • US • Generic • Approved
  • Etonogestrel and Ethinyl Estradiol Vaginal
    Ring • - • Vaginal • US • Generic • Approved
  • Etonogestrel and Ethinyl Estradiol Vaginal Ring
    Ring • - • Vaginal • US • Generic • Approved
  • Etonogestrel/Ethinyl Estradiol
    Insert, extended release • - • Vaginal • US • Generic • Approved
  • Etonogestrel/Ethinyl Estradiol
    Insert, extended release • - • Vaginal • US • Generic • Approved
  • Haloette
    Ring • - • Vaginal • Canada • Approved
Menampilkan 8 dari 22 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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