Peringatan Keamanan

Side effects include pale skin, troubled breathing, unusual bleeding or bruising, unusual tiredness or weakness, black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, shortness of breath, sore throat, sores, ulcers, or white spots on lips or in mouth, swollen glands, increase in bowel movements, loose stools, soft stools.

Raltitrexed

DB00293

small molecule approved investigational

Deskripsi

Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.

Struktur Molekul 2D

Berat 458.488
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 198 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Raltitrexed is transported into cells via a reduced folate carrier. Inside the cell it is extensively polyglutamated by the enzyme folyl polyglutamate synthetase to polyglutamate forms.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

536 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Raltitrexed.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Raltitrexed.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Raltitrexed.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Raltitrexed.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Raltitrexed.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Raltitrexed.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Raltitrexed.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Raltitrexed.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Raltitrexed.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Raltitrexed.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Raltitrexed.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Raltitrexed.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Raltitrexed.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Raltitrexed.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Raltitrexed.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Raltitrexed.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Raltitrexed.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Raltitrexed.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Raltitrexed.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Raltitrexed.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Raltitrexed.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Raltitrexed.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Raltitrexed.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Raltitrexed.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Raltitrexed.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Raltitrexed.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Raltitrexed.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Raltitrexed.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Raltitrexed.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Raltitrexed.
Cladribine Raltitrexed may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Raltitrexed.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Raltitrexed.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Raltitrexed.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Raltitrexed is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Raltitrexed is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Raltitrexed is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Raltitrexed is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Raltitrexed is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Raltitrexed is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Raltitrexed is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Raltitrexed is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Raltitrexed is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Raltitrexed is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Raltitrexed is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Raltitrexed is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Raltitrexed is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Raltitrexed is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Raltitrexed is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Raltitrexed is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Raltitrexed is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Raltitrexed is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Raltitrexed is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Raltitrexed is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Raltitrexed is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Raltitrexed is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Raltitrexed is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Raltitrexed is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Raltitrexed is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Raltitrexed is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Raltitrexed is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Raltitrexed is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Raltitrexed is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Raltitrexed is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Raltitrexed is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Raltitrexed is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Raltitrexed is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Raltitrexed is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Raltitrexed is combined with Melphalan.

Target Protein

Thymidylate synthase TMP1
Thymidylate synthase TYMS
Folylpolyglutamate synthase, mitochondrial FPGS

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 1 • International brands: 0
Produk
  • Tomudex
    Powder, for solution • 2 mg / vial • Intravenous • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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