Peringatan Keamanan

Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.

Etomidate

DB00292

small molecule approved

Deskripsi

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.

Struktur Molekul 2D

Berat 244.289
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 75 minutes.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic. Metabolized rapidly by ester hydrolysis to inactive metabolites.

Rute Eliminasi

Approximately 75% of the administered dose is excreted in the urine during the first day after injection.

Interaksi Obat

1593 Data
Valsartan Etomidate may decrease the antihypertensive activities of Valsartan.
Ramipril Etomidate may decrease the antihypertensive activities of Ramipril.
Remikiren Etomidate may decrease the antihypertensive activities of Remikiren.
Olmesartan Etomidate may decrease the antihypertensive activities of Olmesartan.
Diltiazem Etomidate may decrease the antihypertensive activities of Diltiazem.
Minoxidil Etomidate may decrease the antihypertensive activities of Minoxidil.
Treprostinil Etomidate may decrease the antihypertensive activities of Treprostinil.
Amlodipine Etomidate may decrease the antihypertensive activities of Amlodipine.
Nimodipine Etomidate may decrease the antihypertensive activities of Nimodipine.
Trandolapril Etomidate may decrease the antihypertensive activities of Trandolapril.
Lercanidipine Etomidate may decrease the antihypertensive activities of Lercanidipine.
Benazepril Etomidate may decrease the antihypertensive activities of Benazepril.
Bosentan Etomidate may decrease the antihypertensive activities of Bosentan.
Enalapril Etomidate may decrease the antihypertensive activities of Enalapril.
Candoxatril Etomidate may decrease the antihypertensive activities of Candoxatril.
Losartan Etomidate may decrease the antihypertensive activities of Losartan.
Moexipril Etomidate may decrease the antihypertensive activities of Moexipril.
Nitroglycerin Etomidate may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Etomidate may decrease the antihypertensive activities of Cryptenamine.
Candesartan cilexetil Etomidate may decrease the antihypertensive activities of Candesartan cilexetil.
Eprosartan Etomidate may decrease the antihypertensive activities of Eprosartan.
Quinapril Etomidate may decrease the antihypertensive activities of Quinapril.
Telmisartan Etomidate may decrease the antihypertensive activities of Telmisartan.
Irbesartan Etomidate may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Etomidate may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Etomidate may decrease the antihypertensive activities of Deserpidine.
Pentolinium Etomidate may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Etomidate may decrease the antihypertensive activities of Trimethaphan.
Captopril Etomidate may decrease the antihypertensive activities of Captopril.
Bepridil Etomidate may decrease the antihypertensive activities of Bepridil.
Cilazapril Etomidate may decrease the antihypertensive activities of Cilazapril.
Saprisartan Etomidate may decrease the antihypertensive activities of Saprisartan.
Spirapril Etomidate may decrease the antihypertensive activities of Spirapril.
Mibefradil Etomidate may decrease the antihypertensive activities of Mibefradil.
Debrisoquine Etomidate may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Etomidate may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Etomidate may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Etomidate may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Etomidate may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Etomidate may decrease the antihypertensive activities of Pinacidil.
Temocapril Etomidate may decrease the antihypertensive activities of Temocapril.
Riociguat Etomidate may decrease the antihypertensive activities of Riociguat.
Aliskiren Etomidate may decrease the antihypertensive activities of Aliskiren.
Lacidipine Etomidate may decrease the antihypertensive activities of Lacidipine.
Manidipine Etomidate may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Etomidate may decrease the antihypertensive activities of Rauwolfia serpentina root.
Selexipag Etomidate may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Etomidate may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Etomidate may decrease the antihypertensive activities of Imidapril.
BQ-123 Etomidate may decrease the antihypertensive activities of BQ-123.
Dihydralazine Etomidate may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Etomidate may decrease the antihypertensive activities of Zofenopril.
Guanoxan Etomidate may decrease the antihypertensive activities of Guanoxan.
Delapril Etomidate may decrease the antihypertensive activities of Delapril.
Vincamine Etomidate may decrease the antihypertensive activities of Vincamine.
Linsidomine Etomidate may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Etomidate may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Etomidate may decrease the antihypertensive activities of Tolonidine.
Endralazine Etomidate may decrease the antihypertensive activities of Endralazine.
Cadralazine Etomidate may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Etomidate may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Etomidate may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Etomidate may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Etomidate may decrease the antihypertensive activities of Guanoclor.
Candesartan Etomidate may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Etomidate may decrease the antihypertensive activities of Dexniguldipine.
Tocopherylquinone Etomidate may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Etomidate may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Etomidate may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Etomidate may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Etomidate may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Etomidate may decrease the antihypertensive activities of Quinaprilat.
Felodipine Etomidate may decrease the antihypertensive activities of Felodipine.
Levamlodipine Etomidate may decrease the antihypertensive activities of Levamlodipine.
Azilsartan medoxomil Etomidate may decrease the antihypertensive activities of Azilsartan medoxomil.
Diazoxide Etomidate may decrease the antihypertensive activities of Diazoxide.
Buprenorphine Etomidate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Hydrocodone Etomidate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Magnesium sulfate The therapeutic efficacy of Etomidate can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Etomidate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Etomidate may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Mirtazapine Etomidate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Orphenadrine Etomidate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Etomidate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Pramipexole Etomidate may increase the sedative activities of Pramipexole.
Ropinirole Etomidate may increase the sedative activities of Ropinirole.
Rotigotine Etomidate may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Etomidate.
Suvorexant Etomidate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Thalidomide Etomidate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Etomidate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Etomidate.

Target Protein

Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3
Gamma-aminobutyric acid receptor subunit alpha-1 GABRA1
Alpha-2B adrenergic receptor ADRA2B
GABA(A) Receptor GABRA1

Referensi & Sumber

Synthesis reference: Douglas E. Raines, "ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS." U.S. Patent US20130079381, issued March 28, 2013.

Contoh Produk & Brand

Produk: 59 • International brands: 1
Produk
  • Amidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
  • Amidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
  • Amidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
  • Amidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
  • Amidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
  • Amidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
  • Amidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
  • Amidate(tm) Etomidate
    Injection, solution • 2 mg/1mL • Intravenous • US • Approved
Menampilkan 8 dari 59 produk.
International Brands
  • Hypnomidate — Janssen

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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