Chlorambucil

DB00291

small molecule approved

Deskripsi

A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)

Struktur Molekul 2D

Berat 304.212
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.5 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Chlorambucil is extensively metabolized in the liver primarily to phenylacetic acid mustard. The pharmacokinetic data suggests that oral chlorambucil undergoes rapid gastrointestinal absorption and plasma clearance and that it is almost completely metabolized, having extremely low urinary excretion.

Interaksi Makanan

3 Data
  • 1. Avoid echinacea. Echinacea should be used with caution, if at all, in patients receiving therapeutic immunosuppressants. Monitor for reduced efficacy of the immunosuppressant during concomitant use.
  • 2. Drink plenty of fluids.
  • 3. Take on an empty stomach. Co-administration with food decreases bioavailability.

Interaksi Obat

616 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Chlorambucil.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Chlorambucil.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Chlorambucil.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Chlorambucil.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Chlorambucil.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Chlorambucil.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Chlorambucil.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Chlorambucil.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Chlorambucil.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Chlorambucil.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Chlorambucil.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Chlorambucil.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Chlorambucil.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Chlorambucil.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Chlorambucil.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Chlorambucil.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Chlorambucil.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Chlorambucil.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Chlorambucil.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Chlorambucil.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Chlorambucil.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Chlorambucil.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Chlorambucil.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Chlorambucil.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Chlorambucil.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Chlorambucil.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Chlorambucil.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Chlorambucil.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Chlorambucil.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Chlorambucil.
Cladribine Chlorambucil may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Chlorambucil.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Chlorambucil.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Chlorambucil.
Raltitrexed The risk or severity of adverse effects can be increased when Chlorambucil is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Chlorambucil is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Chlorambucil is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Chlorambucil is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Chlorambucil is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Chlorambucil is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Chlorambucil is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Chlorambucil is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Chlorambucil is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Chlorambucil is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Chlorambucil is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Chlorambucil is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Chlorambucil is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Chlorambucil is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Chlorambucil is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Chlorambucil is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Chlorambucil is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Chlorambucil is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Chlorambucil is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Chlorambucil is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Chlorambucil is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Chlorambucil is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Chlorambucil is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Chlorambucil is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Chlorambucil is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Chlorambucil is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Chlorambucil is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Chlorambucil is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Chlorambucil is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Chlorambucil is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Chlorambucil is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Chlorambucil is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Chlorambucil is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Chlorambucil is combined with Melphalan.

Target Protein

DNA

Referensi & Sumber

Synthesis reference: Phillips, A. P. and Mentha, J.W.; U.S.Patent 3,046,301; July 24, 1962; assigned to Burroughs Wellcome & Co. (U.S.A.) Inc.
Artikel (PubMed)
  • PMID: 11114313
    Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd L, Hines J, Threatte GA, Larson RA, Cheson BD, Schiffer CA: Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000 Dec 14;343(24):1750-7.
  • PMID: 19160296
    Yang K, Tan J, Wu T: Alkylating agents for Waldenstrom's macroglobulinaemia. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006719. doi: 10.1002/14651858.CD006719.pub3.
  • PMID: 20033051
    Foon KA, Hallek MJ: Changing paradigms in the treatment of chronic lymphocytic leukemia. Leukemia. 2010 Mar;24(3):500-11. doi: 10.1038/leu.2009.266. Epub 2009 Dec 24.

Contoh Produk & Brand

Produk: 6 • International brands: 2
Produk
  • Leukeran
    Tablet, film coated • 2 mg/1 • Oral • US • Approved
  • Leukeran
    Tablet, film coated • 2 mg/1 • Oral • US • Approved
  • Leukeran
    Tablet, film coated • 2 mg/1 • Oral • US • Approved
  • Leukeran
    Tablet • 2 mg • Oral • Canada • Approved
  • Leukeran
    Tablet, film coated • 2 mg/1 • Oral • US • Approved
  • Leukeran
    Tablet, film coated • 2 mg/1 • Oral • US • Approved
International Brands
  • Celkeran — Celon
  • Chloraminophène — Techni-Pharma

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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