Peringatan Keamanan

Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.

Bleomycin

DB00290

small molecule approved investigational

Deskripsi

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.

Struktur Molekul 2D

Berat 1415.552
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 115 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Systemic absorption is approximately 45%.

Metabolisme

Hepatic

Rute Eliminasi

It was reported that patients with moderately severe renal failure excreted less than 20% of the dose in the urine.

Farmakogenomik

1 Varian
BLMH (rs10500565)

Patients with this genotype have reduced survival time and increased frequency of early relapse when using bleomycin to treat testicular cancer.

Interaksi Obat

1095 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Bleomycin.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Bleomycin.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Bleomycin.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Bleomycin.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Bleomycin.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Bleomycin.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Bleomycin.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Bleomycin.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Bleomycin.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Bleomycin.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Bleomycin.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Bleomycin.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Bleomycin.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Bleomycin.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Bleomycin.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Bleomycin.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Bleomycin.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Bleomycin.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Bleomycin.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Bleomycin.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Bleomycin.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Bleomycin.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Bleomycin.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Bleomycin.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Bleomycin.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Bleomycin.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Bleomycin.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Bleomycin.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Bleomycin.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Bleomycin.
Cladribine Bleomycin may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Bleomycin.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Bleomycin.
Chlorambucil The risk or severity of adverse effects can be increased when Bleomycin is combined with Chlorambucil.
Raltitrexed The risk or severity of adverse effects can be increased when Bleomycin is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Bleomycin is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Bleomycin is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Bleomycin is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Bleomycin is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Bleomycin is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Bleomycin is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Bleomycin is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Bleomycin is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Bleomycin is combined with Trifluridine.
Betamethasone The risk or severity of adverse effects can be increased when Bleomycin is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Bleomycin is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Bleomycin is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Bleomycin is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Bleomycin is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Bleomycin is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Bleomycin is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Bleomycin is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Bleomycin is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Bleomycin is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Bleomycin is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Bleomycin is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Bleomycin is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Bleomycin is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Bleomycin is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Bleomycin is combined with Daunorubicin.
Tretinoin The risk or severity of cardiotoxicity can be increased when Bleomycin is combined with Tretinoin.
Irinotecan The risk or severity of adverse effects can be increased when Bleomycin is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Bleomycin is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Bleomycin is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Bleomycin is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Bleomycin is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Bleomycin is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Bleomycin is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Bleomycin is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Bleomycin is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Bleomycin is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Bleomycin is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Bleomycin is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Bleomycin is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Bleomycin is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Bleomycin is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Bleomycin is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Bleomycin is combined with Melphalan.

Target Protein

DNA
DNA ligase 1 LIG1
DNA ligase 3 LIG3

Referensi & Sumber

Synthesis reference: Hamao Umezawa, Kenji Maeda, Tomohisa Takita, Yuya Nakayama, Akio Fujii, Nobuyoshi Shimada, Hideo Chimura, "Novel process for producing antibiotics bleomycin." U.S. Patent USRE0304514, issued October, 1970.
Artikel (PubMed)
  • PMID: 11749501
    Claussen CA, Long EC: Nucleic Acid recognition by metal complexes of bleomycin. Chem Rev. 1999 Sep 8;99(9):2797-816.

Contoh Produk & Brand

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