Peringatan Keamanan

No cases of overdose have been reported for travoprost, as overdose from topical or ophthalmic administration is not likely to occur. Overdose from topical administration should be responded to with flushing of the eyes with lukewarm water. Treatment of an oral overdose should be symptomatic and supportive.^L5146

Travoprost

DB00287

small molecule approved

Deskripsi

Travoprost is a synthetic isopropyl ester prodrug of a prostaglandin F2alpha (F2?) analogue and selective FP prostanoid receptor agonist. It is used to decrease intraocular pressure in open-angle glaucoma and ocular hypertension.^L49434 Unlike other prostaglandin analogues, travoprost demonstrates full agonism and high selectivity at the prostanoid receptor, reporting a higher efficacy in reducing intraocular pressure and a reduced risk for developing off-target side effects.^A262904

Struktur Molekul 2D

Berat 500.5477

Wujud liquid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The terminal elimination half-life of travoprost free acid was estimated from fourteen subjects and ranged from 17 minutes to 86 minutes with the mean half-life of 45 minutes.[L49434]

Volume Distribusi No information is available.

Klirens (Clearance) No information is available.

Absorpsi

Following ophthalmic administration, travoprost is absorbed through the cornea. In many patients in multiple-dose pharmacokinetic studies, the plasma concentrations of the free acid were below 0.01 ng/mL, which was the quantitation limit of the assay. In these studies, the mean plasma C_max of travoprost free acid was 0.018 ± 0.007 ng/mL (ranging from 0.01 to 0.052 ng/mL), and the T_max was about 30 minutes.^L49434

Metabolisme

Travoprost, an isopropyl ester prodrug, is hydrolyzed by esterases in the cornea to its biologically active free acid. Systemically, travoprost free acid is metabolized to inactive metabolites via beta-oxidation of the ? (carboxylic acid) chain to give the 1,2-dinor and 1,2,3,4-tetranor analogs, via oxidation of the 15-hydroxyl moiety, as well as via reduction of the 13, 14 double bond.L5146, L49434

Rute Eliminasi

The elimination of travoprost free acid from plasma is rapid. The levels of travoprost free acid were generally below the limit of quantification within one hour after dosing. Less than 2% of the topical ocular dose of travoprost was excreted in the urine within 4 hours as the travoprost free acid.^L49434

Interaksi Obat

105 Data

Icosapent	The therapeutic efficacy of Travoprost can be decreased when used in combination with Icosapent.
Indomethacin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Indomethacin.
Nabumetone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Nabumetone.
Ketorolac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Ketorolac.
Tenoxicam	The therapeutic efficacy of Travoprost can be decreased when used in combination with Tenoxicam.
Celecoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Celecoxib.
Tolmetin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Tolmetin.
Rofecoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Rofecoxib.
Piroxicam	The therapeutic efficacy of Travoprost can be decreased when used in combination with Piroxicam.
Fenoprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Fenoprofen.
Valdecoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Valdecoxib.
Diclofenac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Diclofenac.
Sulindac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Sulindac.
Flurbiprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Flurbiprofen.
Etodolac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Etodolac.
Mefenamic acid	The therapeutic efficacy of Travoprost can be decreased when used in combination with Mefenamic acid.
Naproxen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Naproxen.
Sulfasalazine	The therapeutic efficacy of Travoprost can be decreased when used in combination with Sulfasalazine.
Phenylbutazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Phenylbutazone.
Meloxicam	The therapeutic efficacy of Travoprost can be decreased when used in combination with Meloxicam.
Carprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Carprofen.
Diflunisal	The therapeutic efficacy of Travoprost can be decreased when used in combination with Diflunisal.
Salicylic acid	The therapeutic efficacy of Travoprost can be decreased when used in combination with Salicylic acid.
Meclofenamic acid	The therapeutic efficacy of Travoprost can be decreased when used in combination with Meclofenamic acid.
Acetylsalicylic acid	The therapeutic efficacy of Travoprost can be decreased when used in combination with Acetylsalicylic acid.
Oxaprozin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Oxaprozin.
Ketoprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Ketoprofen.
Balsalazide	The therapeutic efficacy of Travoprost can be decreased when used in combination with Balsalazide.
Ibuprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Ibuprofen.
Lumiracoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Lumiracoxib.
Magnesium salicylate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Magnesium salicylate.
Salsalate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Salsalate.
Choline magnesium trisalicylate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Choline magnesium trisalicylate.
Antrafenine	The therapeutic efficacy of Travoprost can be decreased when used in combination with Antrafenine.
Aminophenazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Aminophenazone.
Antipyrine	The therapeutic efficacy of Travoprost can be decreased when used in combination with Antipyrine.
Tiaprofenic acid	The therapeutic efficacy of Travoprost can be decreased when used in combination with Tiaprofenic acid.
Etoricoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Etoricoxib.
Taxifolin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Taxifolin.
Oxyphenbutazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Oxyphenbutazone.
Licofelone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Licofelone.
Nimesulide	The therapeutic efficacy of Travoprost can be decreased when used in combination with Nimesulide.
Benoxaprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Benoxaprofen.
Zomepirac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Zomepirac.
Cimicoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Cimicoxib.
Lornoxicam	The therapeutic efficacy of Travoprost can be decreased when used in combination with Lornoxicam.
Aceclofenac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Aceclofenac.
Zaltoprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Zaltoprofen.
Azapropazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Azapropazone.
Parecoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Parecoxib.
Salicylamide	The therapeutic efficacy of Travoprost can be decreased when used in combination with Salicylamide.
Kebuzone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Kebuzone.
Isoxicam	The therapeutic efficacy of Travoprost can be decreased when used in combination with Isoxicam.
Indoprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Indoprofen.
Ibuproxam	The therapeutic efficacy of Travoprost can be decreased when used in combination with Ibuproxam.
Floctafenine	The therapeutic efficacy of Travoprost can be decreased when used in combination with Floctafenine.
Fenbufen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Fenbufen.
Etofenamate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Etofenamate.
Epirizole	The therapeutic efficacy of Travoprost can be decreased when used in combination with Epirizole.
Benzydamine	The therapeutic efficacy of Travoprost can be decreased when used in combination with Benzydamine.
Dexibuprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Dexibuprofen.
Dexketoprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Dexketoprofen.
Droxicam	The therapeutic efficacy of Travoprost can be decreased when used in combination with Droxicam.
Tolfenamic acid	The therapeutic efficacy of Travoprost can be decreased when used in combination with Tolfenamic acid.
Firocoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Firocoxib.
Clonixin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Clonixin.
Morniflumate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Morniflumate.
Propacetamol	The therapeutic efficacy of Travoprost can be decreased when used in combination with Propacetamol.
Talniflumate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Talniflumate.
Robenacoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Robenacoxib.
Tepoxalin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Tepoxalin.
Flunixin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Flunixin.
Polmacoxib	The therapeutic efficacy of Travoprost can be decreased when used in combination with Polmacoxib.
Nitroaspirin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Nitroaspirin.
Indobufen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Indobufen.
Ebselen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Ebselen.
Tinoridine	The therapeutic efficacy of Travoprost can be decreased when used in combination with Tinoridine.
Alclofenac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Alclofenac.
Fentiazac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Fentiazac.
Suxibuzone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Suxibuzone.
Bumadizone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Bumadizone.
Alminoprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Alminoprofen.
Difenpiramide	The therapeutic efficacy of Travoprost can be decreased when used in combination with Difenpiramide.
Nifenazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Nifenazone.
Lonazolac	The therapeutic efficacy of Travoprost can be decreased when used in combination with Lonazolac.
Tenidap	The therapeutic efficacy of Travoprost can be decreased when used in combination with Tenidap.
Propyphenazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Propyphenazone.
Proglumetacin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Proglumetacin.
Guacetisal	The therapeutic efficacy of Travoprost can be decreased when used in combination with Guacetisal.
Ethenzamide	The therapeutic efficacy of Travoprost can be decreased when used in combination with Ethenzamide.
Carbaspirin calcium	The therapeutic efficacy of Travoprost can be decreased when used in combination with Carbaspirin calcium.
Mofebutazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Mofebutazone.
Proquazone	The therapeutic efficacy of Travoprost can be decreased when used in combination with Proquazone.
Benorilate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Benorilate.
Pirprofen	The therapeutic efficacy of Travoprost can be decreased when used in combination with Pirprofen.
Acemetacin	The therapeutic efficacy of Travoprost can be decreased when used in combination with Acemetacin.
Imidazole salicylate	The therapeutic efficacy of Travoprost can be decreased when used in combination with Imidazole salicylate.
SC-236	The therapeutic efficacy of Travoprost can be decreased when used in combination with SC-236.
NS-398	The therapeutic efficacy of Travoprost can be decreased when used in combination with NS-398.
Flurbiprofen axetil	The therapeutic efficacy of Travoprost can be decreased when used in combination with Flurbiprofen axetil.

Target Protein

Prostaglandin F2-alpha receptor PTGFR

Referensi & Sumber

Artikel (PubMed)

PMID: 12149052
Waugh J, Jarvis B: Travoprost. Drugs Aging. 2002;19(6):465-71; discussion 472-3. doi: 10.2165/00002512-200219060-00005.
PMID: 12083996
Whitson JT: Travoprost--a new prostaglandin analogue for the treatment of glaucoma. Expert Opin Pharmacother. 2002 Jul;3(7):965-77. doi: 10.1517/14656566.3.7.965.
PMID: 12669109
Al-Jazzaf AM, DeSantis L, Netland PA: Travoprost: a potent ocular hypotensive agent. Drugs Today (Barc). 2003 Jan;39(1):61-74. doi: 10.1358/dot.2003.39.1.799432.

Link

Contoh Produk & Brand

Produk: 48 • International brands: 1

Produk

Apo-travoprost

Solution • 0.003 % w/v • Ophthalmic • Canada • Generic • Approved
Apo-travoprost Z

Solution • 0.004 % w/v • Ophthalmic • Canada • Generic • Approved
Apo-travoprost-timolol Pq

Solution • - • Ophthalmic • Canada • Generic • Approved
Apo-travoprost-timop Pq

Solution • - • Ophthalmic • Canada • Generic • Approved
Duotrav

Solution / drops • - • Ophthalmic • EU • Approved
Duotrav

Solution / drops • - • Ophthalmic • EU • Approved
Duotrav

Solution / drops • - • Ophthalmic • EU • Approved
Duotrav

Solution / drops • - • Ophthalmic • EU • Approved

Menampilkan 8 dari 48 produk.

International Brands

Travo-Z

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.