Peringatan Keamanan

The reported oral LD50 of liothyronine in the rat is higher than 4540 mg/kg. When overdosage is registered, symptoms of hyperthyroidism are reported as well as confusion, disorientation, cerebral embolism, seizure, shock, coma, and death. The symptoms of overdose can be presented immediately or several days after overdose ingestion. In an overdose state, reduce the dose of liothyronine and do supportive treatment.FDA label

There are no reports studying the carcinogenic, and mutagenic potential nor on the effects of liothyronine on fertility.FDA label

Liothyronine

DB00279

small molecule approved vet_approved

Deskripsi

Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine.T457 The exogenous liothyronine product was developed by King Pharmaceuticals and FDA approved in 1956.L5578

Struktur Molekul 2D

Berat 650.9735
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life of liothyronine is reported to be between 1 and 2 days.[T460]
Volume Distribusi The reported volume of distribution of liothyronine is reported to be of 0.1-0.2 L/kg.[T122]
Klirens (Clearance) There are no reports obtaining this value specifically.

Absorpsi

Thyroid hormones are well absorbed orally. From these hormones, liothyronine is almost completely absorbed and it does not present changes in the absorption rate due to concomitant administration of food.T322liothyronin Multiple administration of 50 mcg of liothyronine provided a maximal plasma concentration of total T3 of 346 ng/dL in about 2.5 hours with an AUC of 4740 ng.h/dL.A175435

Metabolisme

Liothyronine is mainly metabolized in the liver where it is deiodinated to diiodothyronine and monoiodothyronine followed by conjugation with glucuronides and sulfates.L5587 One of the formed metabolites formed by the conjugation and decarboxylation is tiratricol. The iodine released by the metabolism of liothyronine is later taken and used within the thyroid cells.T122

Rute Eliminasi

The main elimination of thyroid hormones is known to be done via the kidneys from which less than 2.5% of the excreted drug is represented by the unchanged drug. This elimination route is reduced with age. A portion of the metabolic products of liothyronine is excreted to the bile and gut where they can be part of enterohepatic recirculation.L5587

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

1292 Data
Succinic acid The excretion of Succinic acid can be decreased when combined with Liothyronine.
Citrulline The excretion of Citrulline can be decreased when combined with Liothyronine.
Pravastatin The excretion of Pravastatin can be decreased when combined with Liothyronine.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Liothyronine.
Zidovudine The excretion of Zidovudine can be decreased when combined with Liothyronine.
Cefdinir The excretion of Cefdinir can be decreased when combined with Liothyronine.
Leucovorin The excretion of Leucovorin can be decreased when combined with Liothyronine.
Fluorescein The excretion of Fluorescein can be decreased when combined with Liothyronine.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Liothyronine.
Quinapril The excretion of Quinapril can be decreased when combined with Liothyronine.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Liothyronine.
Famotidine The excretion of Famotidine can be decreased when combined with Liothyronine.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Liothyronine.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Liothyronine.
Captopril The excretion of Captopril can be decreased when combined with Liothyronine.
Tazobactam The excretion of Tazobactam can be decreased when combined with Liothyronine.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Liothyronine.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Liothyronine.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Liothyronine.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Liothyronine.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Liothyronine.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Liothyronine.
Avibactam The excretion of Avibactam can be decreased when combined with Liothyronine.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Liothyronine.
Relebactam The excretion of Relebactam can be decreased when combined with Liothyronine.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Liothyronine.
Cefotiam The excretion of Cefotiam can be decreased when combined with Liothyronine.
Tenofovir disoproxil The excretion of Tenofovir disoproxil can be decreased when combined with Liothyronine.
Indomethacin The excretion of Indomethacin can be decreased when combined with Liothyronine.
Methotrexate The excretion of Methotrexate can be decreased when combined with Liothyronine.
Cephalexin The excretion of Cephalexin can be decreased when combined with Liothyronine.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Liothyronine.
Acyclovir The excretion of Acyclovir can be decreased when combined with Liothyronine.
Cefaclor The excretion of Cefaclor can be decreased when combined with Liothyronine.
Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Liothyronine.
Cefazolin The excretion of Cefazolin can be decreased when combined with Liothyronine.
Ceftizoxime The excretion of Ceftizoxime can be decreased when combined with Liothyronine.
Cefacetrile The excretion of Cefacetrile can be decreased when combined with Liothyronine.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Liothyronine.
Cefaloridine The excretion of Cefaloridine can be decreased when combined with Liothyronine.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Liothyronine.
Tenofovir The excretion of Tenofovir can be decreased when combined with Liothyronine.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Liothyronine.
Piperacillin The excretion of Piperacillin can be decreased when combined with Liothyronine.
Trifluridine The excretion of Trifluridine can be decreased when combined with Liothyronine.
Allopurinol The excretion of Allopurinol can be decreased when combined with Liothyronine.
Cimetidine The excretion of Cimetidine can be decreased when combined with Liothyronine.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Liothyronine.
Tetracycline The excretion of Tetracycline can be decreased when combined with Liothyronine.
Ranitidine The excretion of Ranitidine can be decreased when combined with Liothyronine.
Doripenem The excretion of Doripenem can be decreased when combined with Liothyronine.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Liothyronine.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Liothyronine.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Liothyronine.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Liothyronine.
Nelfinavir The metabolism of Liothyronine can be increased when combined with Nelfinavir.
Desogestrel The metabolism of Liothyronine can be increased when combined with Desogestrel.
Ritonavir The metabolism of Liothyronine can be increased when combined with Ritonavir.
Efavirenz The metabolism of Liothyronine can be increased when combined with Efavirenz.
Primidone The metabolism of Liothyronine can be increased when combined with Primidone.
Tipranavir The metabolism of Liothyronine can be increased when combined with Tipranavir.
Lamotrigine The metabolism of Liothyronine can be increased when combined with Lamotrigine.
Rifampin The metabolism of Liothyronine can be increased when combined with Rifampicin.
Phenytoin The metabolism of Liothyronine can be increased when combined with Phenytoin.
Phenobarbital The metabolism of Liothyronine can be increased when combined with Phenobarbital.
Tolevamer Tolevamer can cause a decrease in the absorption of Liothyronine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chlorotrianisene The therapeutic efficacy of Liothyronine can be decreased when used in combination with Chlorotrianisene.
Tibolone The therapeutic efficacy of Liothyronine can be decreased when used in combination with Tibolone.
Polyestradiol phosphate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Polyestradiol phosphate.
Zeranol The therapeutic efficacy of Liothyronine can be decreased when used in combination with Zeranol.
Equol The therapeutic efficacy of Liothyronine can be decreased when used in combination with Equol.
Methallenestril The therapeutic efficacy of Liothyronine can be decreased when used in combination with Methallenestril.
Epimestrol The therapeutic efficacy of Liothyronine can be decreased when used in combination with Epimestrol.
Moxestrol The therapeutic efficacy of Liothyronine can be decreased when used in combination with Moxestrol.
Estradiol benzoate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Estradiol benzoate.
Biochanin A The therapeutic efficacy of Liothyronine can be decreased when used in combination with Biochanin A.
Formononetin The therapeutic efficacy of Liothyronine can be decreased when used in combination with Formononetin.
Citalopram The therapeutic efficacy of Liothyronine can be decreased when used in combination with Citalopram.
Fluoxetine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Fluoxetine.
Trazodone The therapeutic efficacy of Liothyronine can be decreased when used in combination with Trazodone.
Sertraline The therapeutic efficacy of Liothyronine can be decreased when used in combination with Sertraline.
Escitalopram The therapeutic efficacy of Liothyronine can be decreased when used in combination with Escitalopram.
Zimelidine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Zimelidine.
Dapoxetine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Dapoxetine.
Seproxetine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Seproxetine.
Indalpine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Indalpine.
Ritanserin The therapeutic efficacy of Liothyronine can be decreased when used in combination with Ritanserin.
Alaproclate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Alaproclate.
Paroxetine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Paroxetine.
Colesevelam The therapeutic efficacy of Liothyronine can be decreased when used in combination with Colesevelam.
Calcium acetate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium acetate.
Calcium glucoheptonate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium glucoheptonate.
Calcium chloride The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium chloride.
Calcium The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium.
Calcium carbonate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium carbonate.
Calcium citrate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium citrate.
Calcium gluconate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium gluconate.
Calcium Phosphate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium Phosphate.
Calcium glubionate anhydrous The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium glubionate anhydrous.
Calcium lactate The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium lactate.

Target Protein

Thyroid hormone receptor alpha THRA
Thyroid hormone receptor beta THRB
Proliferating cell nuclear antigen PCNA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 24977379
    Jonklaas J, Burman KD, Wang H, Latham KR: Single-dose T3 administration: kinetics and effects on biochemical and physiological parameters. Ther Drug Monit. 2015 Feb;37(1):110-8. doi: 10.1097/FTD.0000000000000113.
Textbook
  • ISBN: 978-0-7637-6547-7
    Sullivan K. (2009). Nurse's drug handbook (8th ed.). Jones and Bartlett Publishers, LLC.
  • Upfal J. (2007). The Australian Drug Guide (7th ed.). National Library of Australia.
  • ISBN: 978-1-58528-266-1
    Harrold M. and Zavod R. (2013). Basic Concepts in Medicinal Chemistry. American Society of Health-System Pharmacists.
  • Scott-Moncrieff C. (2015). Canine and feline endocrinology (4th ed.). Elsevier.
  • Kumar P. (2017). Pharmacology and therapeutics for dentistry (7th ed.). Mosby.
  • Ashley C. and Dunleavy A. (2014). The renal drug handbook. Caroline Ashley and Aileen Dunleavy.

Contoh Produk & Brand

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International Brands
  • Tertroxin — Aspen Pharmacare

Sekuens Gen/Protein (FASTA)

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