Peringatan Keamanan

Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).

Amsacrine

DB00276

small molecule approved investigational

Deskripsi

Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

Struktur Molekul 2D

Berat 393.459
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8-9 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Poorly absorbed

Metabolisme

Extensive, primarily hepatic, converted to glutathione conjugate.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

546 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Amsacrine.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Amsacrine.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Amsacrine.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Amsacrine.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Amsacrine.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Amsacrine.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Amsacrine.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Amsacrine.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Amsacrine.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Amsacrine.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Amsacrine.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Amsacrine.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Amsacrine.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Amsacrine.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Amsacrine.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Amsacrine.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Amsacrine.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Amsacrine.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Amsacrine.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Amsacrine.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Amsacrine.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Amsacrine.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Amsacrine.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Amsacrine.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Amsacrine.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Amsacrine.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Amsacrine.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Amsacrine.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Amsacrine.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Amsacrine.
Cladribine Amsacrine may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Amsacrine.
Bleomycin The risk or severity of adverse effects can be increased when Amsacrine is combined with Bleomycin.
Chlorambucil The risk or severity of adverse effects can be increased when Amsacrine is combined with Chlorambucil.
Raltitrexed The risk or severity of adverse effects can be increased when Amsacrine is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Amsacrine is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Amsacrine is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Amsacrine is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Amsacrine is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Amsacrine is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Amsacrine is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Amsacrine is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Amsacrine is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Amsacrine is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Amsacrine is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Amsacrine is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Amsacrine is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Amsacrine is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Amsacrine is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Amsacrine is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Amsacrine is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Amsacrine is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Amsacrine is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Amsacrine is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Amsacrine is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Amsacrine is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Amsacrine is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Amsacrine is combined with Cyclophosphamide.
Fluorouracil The risk or severity of adverse effects can be increased when Amsacrine is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Amsacrine is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Amsacrine is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Amsacrine is combined with Methotrexate.
Vinblastine The risk or severity of adverse effects can be increased when Amsacrine is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Amsacrine is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Amsacrine is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Amsacrine is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Amsacrine is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Amsacrine is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Amsacrine is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Amsacrine is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Amsacrine is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Amsacrine is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Amsacrine is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Amsacrine is combined with Daunorubicin.
Tretinoin The risk or severity of cardiotoxicity can be increased when Amsacrine is combined with Tretinoin.
Irinotecan The risk or severity of adverse effects can be increased when Amsacrine is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Amsacrine is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Amsacrine is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Amsacrine is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Amsacrine is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Amsacrine is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Amsacrine is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Amsacrine is combined with Prednisolone.
Mechlorethamine The risk or severity of adverse effects can be increased when Amsacrine is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Amsacrine is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Amsacrine is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Amsacrine is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Amsacrine is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Amsacrine is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Amsacrine is combined with Azathioprine.
Hydroxyurea The risk or severity of adverse effects can be increased when Amsacrine is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Amsacrine is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Amsacrine is combined with Mycophenolic acid.
Mercaptopurine The risk or severity of adverse effects can be increased when Amsacrine is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Amsacrine is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Amsacrine is combined with Melphalan.
Fludarabine The risk or severity of adverse effects can be increased when Amsacrine is combined with Fludarabine.
Flucytosine The risk or severity of adverse effects can be increased when Amsacrine is combined with Flucytosine.
Capecitabine The risk or severity of adverse effects can be increased when Amsacrine is combined with Capecitabine.
Trilostane The risk or severity of adverse effects can be increased when Amsacrine is combined with Trilostane.

Target Protein

DNA
DNA topoisomerase 2-beta TOP2B
DNA topoisomerase 2-alpha TOP2A
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2
Alpha-1-acid glycoprotein 1 ORM1
Albumin ALB

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 1 • International brands: 4
Produk
  • Amsa Pd
    Liquid • 50 mg / mL • Intravenous • Canada • Approved
International Brands
  • Amekrin
  • AMSA P-D
  • Amsidine
  • Amsidyl

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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