Symptoms of overdose include lethargy, sinus tachycardia, and transient hypotension. Significant lethality was observed in mice given oral doses of over 200 mg/kg and rabbits given about 50 mg/kg of isradipine. Rats tolerated doses of over 2000 mg/kg without effects on survival.
Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Isradipine is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Isradipine is combined with Levodopa. |
| Risperidone | Isradipine may increase the hypotensive activities of Risperidone. |
| Troglitazone | Troglitazone may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Reserpine | Reserpine may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Progesterone | Progesterone may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Chlorpromazine | Chlorpromazine may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Bosentan | Bosentan may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Ethinylestradiol | Ethinylestradiol may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Glyburide | Glyburide may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Ursodeoxycholic acid | Ursodeoxycholic acid may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Cholic Acid | Cholic Acid may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Fusidic acid | Fusidic acid may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Simeprevir | Simeprevir may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Lenvatinib | Lenvatinib may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Valinomycin | Valinomycin may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Olmesartan | Olmesartan may decrease the excretion rate of Isradipine which could result in a higher serum level. |
| Pralsetinib | The serum concentration of Pralsetinib can be increased when it is combined with Isradipine. |
| Ceritinib | Isradipine may increase the bradycardic activities of Ceritinib. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Isradipine. |
| Amifostine | Isradipine may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Isradipine. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Isradipine. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Isradipine. |
| Obinutuzumab | Isradipine may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Isradipine. |
| Rituximab | Isradipine may increase the hypotensive activities of Rituximab. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Isradipine. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Isradipine. |
| Norepinephrine | Norepinephrine may decrease the antihypertensive activities of Isradipine. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Isradipine. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Isradipine. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Isradipine. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Isradipine. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Isradipine. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Isradipine. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Isradipine. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Isradipine. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Isradipine. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Isradipine. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Isradipine. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Isradipine. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Isradipine. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Isradipine. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Isradipine. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Isradipine. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Isradipine. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Isradipine. |
| Ephedrine | Ephedrine may decrease the antihypertensive activities of Isradipine. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Isradipine. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Isradipine. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Isradipine. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Isradipine. |
| MMDA | MMDA may decrease the antihypertensive activities of Isradipine. |
| Midomafetamine | Midomafetamine may decrease the antihypertensive activities of Isradipine. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Isradipine. |
| 4-Methoxyamphetamine | 4-Methoxyamphetamine may decrease the antihypertensive activities of Isradipine. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Isradipine. |
| Tenamfetamine | Tenamfetamine may decrease the antihypertensive activities of Isradipine. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Isradipine. |
| Dextroamphetamine | Dextroamphetamine may decrease the antihypertensive activities of Isradipine. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Isradipine. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Isradipine. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Isradipine. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Isradipine. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Isradipine. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Isradipine. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Isradipine. |
| Esmirtazapine | Esmirtazapine may decrease the antihypertensive activities of Isradipine. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Isradipine. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Isradipine. |
| Levonordefrin | Levonordefrin may decrease the antihypertensive activities of Isradipine. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Isradipine. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Isradipine. |
| Cinitapride | Cinitapride may decrease the antihypertensive activities of Isradipine. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Isradipine. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Isradipine. |
| Ifenprodil | Ifenprodil may decrease the antihypertensive activities of Isradipine. |
| Hexoprenaline | Hexoprenaline may decrease the antihypertensive activities of Isradipine. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Isradipine. |
| Cirazoline | Cirazoline may decrease the antihypertensive activities of Isradipine. |
| Synephrine | Synephrine may decrease the antihypertensive activities of Isradipine. |
| Oxaprotiline | Oxaprotiline may decrease the antihypertensive activities of Isradipine. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the antihypertensive activities of Isradipine. |
| Racepinephrine | Racepinephrine may decrease the antihypertensive activities of Isradipine. |
| Amitraz | Amitraz may decrease the antihypertensive activities of Isradipine. |
| Medetomidine | Medetomidine may decrease the antihypertensive activities of Isradipine. |
| Xylazine | Xylazine may decrease the antihypertensive activities of Isradipine. |
| Atipamezole | Atipamezole may decrease the antihypertensive activities of Isradipine. |
| Ractopamine | Ractopamine may decrease the antihypertensive activities of Isradipine. |
| Romifidine | Romifidine may decrease the antihypertensive activities of Isradipine. |
| Detomidine | Detomidine may decrease the antihypertensive activities of Isradipine. |
| Tetrahydrocannabivarin | Tetrahydrocannabivarin may decrease the antihypertensive activities of Isradipine. |
| PF-00610355 | PF-00610355 may decrease the antihypertensive activities of Isradipine. |
| Ritobegron | Ritobegron may decrease the antihypertensive activities of Isradipine. |
| Abediterol | Abediterol may decrease the antihypertensive activities of Isradipine. |
| Tulobuterol | Tulobuterol may decrease the antihypertensive activities of Isradipine. |
| Dopexamine | Dopexamine may decrease the antihypertensive activities of Isradipine. |
| Piclozotan | Piclozotan may decrease the antihypertensive activities of Isradipine. |
| Idazoxan | Idazoxan may decrease the antihypertensive activities of Isradipine. |