Peringatan Keamanan

Acute overdosage of large doses of oral contraceptives in chidren reportedly produces almost no toxicity except nausea and vomiting. Acute overdosage of estrogens may cause nausea, and withdrawal bleeding may occur in females.

Chlorotrianisene

DB00269

small molecule investigational withdrawn

Deskripsi

A powerful synthetic, non-steroidal estrogen. PubChem

Struktur Molekul 2D

Berat 380.864
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorption following oral administration is rapid.

Metabolisme

Metabolized principally in the liver, although the kidneys, gonads, and muscle tissues may be involved to some extent. The metabolic fate of the synthetic estrogens has not been fully elucidated.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

587 Data
Prasterone The risk or severity of adverse effects can be increased when Prasterone is combined with Chlorotrianisene.
Exemestane The therapeutic efficacy of Exemestane can be decreased when used in combination with Chlorotrianisene.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Chlorotrianisene.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Chlorotrianisene.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Chlorotrianisene.
Lenalidomide Chlorotrianisene may increase the thrombogenic activities of Lenalidomide.
Ospemifene The risk or severity of adverse effects can be increased when Chlorotrianisene is combined with Ospemifene.
Ropinirole Chlorotrianisene may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide Chlorotrianisene may increase the thrombogenic activities of Thalidomide.
Cetuximab Chlorotrianisene may increase the thrombogenic activities of Cetuximab.
Human immunoglobulin G Chlorotrianisene may increase the thrombogenic activities of Human immunoglobulin G.
Omalizumab Chlorotrianisene may increase the thrombogenic activities of Omalizumab.
Adalimumab Chlorotrianisene may increase the thrombogenic activities of Adalimumab.
Gemtuzumab ozogamicin Chlorotrianisene may increase the thrombogenic activities of Gemtuzumab ozogamicin.
Indium In-111 satumomab pendetide Chlorotrianisene may increase the thrombogenic activities of Indium In-111 satumomab pendetide.
Infliximab Chlorotrianisene may increase the thrombogenic activities of Infliximab.
Trastuzumab Chlorotrianisene may increase the thrombogenic activities of Trastuzumab.
Rituximab Chlorotrianisene may increase the thrombogenic activities of Rituximab.
Basiliximab Chlorotrianisene may increase the thrombogenic activities of Basiliximab.
Muromonab Chlorotrianisene may increase the thrombogenic activities of Muromonab.
Digoxin Immune Fab (Ovine) Chlorotrianisene may increase the thrombogenic activities of Digoxin Immune Fab (Ovine).
Ibritumomab tiuxetan Chlorotrianisene may increase the thrombogenic activities of Ibritumomab tiuxetan.
Tositumomab Chlorotrianisene may increase the thrombogenic activities of Tositumomab.
Alemtuzumab Chlorotrianisene may increase the thrombogenic activities of Alemtuzumab.
Capromab pendetide Chlorotrianisene may increase the thrombogenic activities of Capromab pendetide.
Efalizumab Chlorotrianisene may increase the thrombogenic activities of Efalizumab.
Antithymocyte immunoglobulin (rabbit) Chlorotrianisene may increase the thrombogenic activities of Antithymocyte immunoglobulin (rabbit).
Natalizumab Chlorotrianisene may increase the thrombogenic activities of Natalizumab.
Palivizumab Chlorotrianisene may increase the thrombogenic activities of Palivizumab.
Daclizumab Chlorotrianisene may increase the thrombogenic activities of Daclizumab.
Bevacizumab Chlorotrianisene may increase the thrombogenic activities of Bevacizumab.
Technetium Tc-99m arcitumomab Chlorotrianisene may increase the thrombogenic activities of Technetium Tc-99m arcitumomab.
Eculizumab Chlorotrianisene may increase the thrombogenic activities of Eculizumab.
Panitumumab Chlorotrianisene may increase the thrombogenic activities of Panitumumab.
Ranibizumab Chlorotrianisene may increase the thrombogenic activities of Ranibizumab.
Galiximab Chlorotrianisene may increase the thrombogenic activities of Galiximab.
Pexelizumab Chlorotrianisene may increase the thrombogenic activities of Pexelizumab.
Afelimomab Chlorotrianisene may increase the thrombogenic activities of Afelimomab.
Epratuzumab Chlorotrianisene may increase the thrombogenic activities of Epratuzumab.
Bectumomab Chlorotrianisene may increase the thrombogenic activities of Bectumomab.
Oregovomab Chlorotrianisene may increase the thrombogenic activities of Oregovomab.
IGN311 Chlorotrianisene may increase the thrombogenic activities of IGN311.
Adecatumumab Chlorotrianisene may increase the thrombogenic activities of Adecatumumab.
Labetuzumab Chlorotrianisene may increase the thrombogenic activities of Labetuzumab.
Matuzumab Chlorotrianisene may increase the thrombogenic activities of Matuzumab.
Fontolizumab Chlorotrianisene may increase the thrombogenic activities of Fontolizumab.
Bavituximab Chlorotrianisene may increase the thrombogenic activities of Bavituximab.
CR002 Chlorotrianisene may increase the thrombogenic activities of CR002.
Rozrolimupab Chlorotrianisene may increase the thrombogenic activities of Rozrolimupab.
Girentuximab Chlorotrianisene may increase the thrombogenic activities of Girentuximab.
Obiltoxaximab Chlorotrianisene may increase the thrombogenic activities of Obiltoxaximab.
XTL-001 Chlorotrianisene may increase the thrombogenic activities of XTL-001.
NAV 1800 Chlorotrianisene may increase the thrombogenic activities of NAV 1800.
Briakinumab Chlorotrianisene may increase the thrombogenic activities of Briakinumab.
Otelixizumab Chlorotrianisene may increase the thrombogenic activities of Otelixizumab.
AMG 108 Chlorotrianisene may increase the thrombogenic activities of AMG 108.
Iratumumab Chlorotrianisene may increase the thrombogenic activities of Iratumumab.
Enokizumab Chlorotrianisene may increase the thrombogenic activities of Enokizumab.
Ramucirumab Chlorotrianisene may increase the thrombogenic activities of Ramucirumab.
Farletuzumab Chlorotrianisene may increase the thrombogenic activities of Farletuzumab.
Veltuzumab Chlorotrianisene may increase the thrombogenic activities of Veltuzumab.
Ustekinumab Chlorotrianisene may increase the thrombogenic activities of Ustekinumab.
Trastuzumab emtansine Chlorotrianisene may increase the thrombogenic activities of Trastuzumab emtansine.
PRO-542 Chlorotrianisene may increase the thrombogenic activities of PRO-542.
TNX-901 Chlorotrianisene may increase the thrombogenic activities of TNX-901.
Inotuzumab ozogamicin Chlorotrianisene may increase the thrombogenic activities of Inotuzumab ozogamicin.
RI 624 Chlorotrianisene may increase the thrombogenic activities of RI 624.
Stamulumab Chlorotrianisene may increase the thrombogenic activities of MYO-029.
CT-011 Chlorotrianisene may increase the thrombogenic activities of CT-011.
Leronlimab Chlorotrianisene may increase the thrombogenic activities of Leronlimab.
Glembatumumab vedotin Chlorotrianisene may increase the thrombogenic activities of Glembatumumab vedotin.
Olaratumab Chlorotrianisene may increase the thrombogenic activities of Olaratumab.
IPH 2101 Chlorotrianisene may increase the thrombogenic activities of IPH 2101.
TB-402 Chlorotrianisene may increase the thrombogenic activities of TB-402.
Caplacizumab Chlorotrianisene may increase the thrombogenic activities of Caplacizumab.
IMC-1C11 Chlorotrianisene may increase the thrombogenic activities of IMC-1C11.
Eldelumab Chlorotrianisene may increase the thrombogenic activities of Eldelumab.
Lumiliximab Chlorotrianisene may increase the thrombogenic activities of Lumiliximab.
Canakinumab Chlorotrianisene may increase the thrombogenic activities of Canakinumab.
Ipilimumab Chlorotrianisene may increase the thrombogenic activities of Ipilimumab.
Nimotuzumab Chlorotrianisene may increase the thrombogenic activities of Nimotuzumab.
Clenoliximab Chlorotrianisene may increase the thrombogenic activities of Clenoliximab.
Tocilizumab Chlorotrianisene may increase the thrombogenic activities of Tocilizumab.
BIIB015 Chlorotrianisene may increase the thrombogenic activities of BIIB015.
Sonepcizumab Chlorotrianisene may increase the thrombogenic activities of Sonepcizumab.
Motavizumab Chlorotrianisene may increase the thrombogenic activities of Motavizumab.
Elotuzumab Chlorotrianisene may increase the thrombogenic activities of Elotuzumab.
AVE9633 Chlorotrianisene may increase the thrombogenic activities of AVE9633.
Carotuximab Chlorotrianisene may increase the thrombogenic activities of Carotuximab.
XmAb 2513 Chlorotrianisene may increase the thrombogenic activities of XmAb 2513.
Coltuximab ravtansine Chlorotrianisene may increase the thrombogenic activities of Coltuximab ravtansine.
Lucatumumab Chlorotrianisene may increase the thrombogenic activities of Lucatumumab.
Pertuzumab Chlorotrianisene may increase the thrombogenic activities of Pertuzumab.
Siplizumab Chlorotrianisene may increase the thrombogenic activities of Siplizumab.
Apolizumab Chlorotrianisene may increase the thrombogenic activities of Apolizumab.
Sibrotuzumab Chlorotrianisene may increase the thrombogenic activities of Sibrotuzumab.
Bivatuzumab Chlorotrianisene may increase the thrombogenic activities of Bivatuzumab.
Lerdelimumab Chlorotrianisene may increase the thrombogenic activities of Lerdelimumab.
Lexatumumab Chlorotrianisene may increase the thrombogenic activities of Lexatumumab.
Reslizumab Chlorotrianisene may increase the thrombogenic activities of Reslizumab.

Target Protein

Estrogen receptor ESR1

Referensi & Sumber

Synthesis reference: Shelton, R.S. and Van Campen, M.G. Jr.; U S . Patent 2,430,891; November 18,1947; assigned to the Wm. S. Merrell Company.

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
  • Merbentul — Merrell
  • Tace — Merrell
  • Tace FN — Merrell
  • Triagen — Gentili

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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