Peringatan Keamanan

Information on cefmenoxime overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.

Cefmenoxime

DB00267

small molecule approved

Deskripsi

Cefmenoxime is a novel broad-spectrum and third-generation cephalosporin antibiotic that is typically used in the treatment of female gynecologic and obstetric infections. It is reported to exhibit high activity against a wide variety of gram-positive and gram-negative bacteria.

Struktur Molekul 2D

Berat 511.558
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1 hour
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Bioavailability is approximately 100% following intramuscular injection.

Metabolisme

Not appreciably metabolized.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

796 Data
Probenecid The serum concentration of Cefmenoxime can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefmenoxime.
Tenofovir disoproxil Cefmenoxime may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefmenoxime may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefmenoxime may increase the nephrotoxic activities of Tenofovir.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefmenoxime.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefmenoxime.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefmenoxime.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefmenoxime.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefmenoxime.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefmetazole.
Indomethacin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Indomethacin.
Triamterene The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Triamterene.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefpiramide.
Loracarbef The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Loracarbef.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefalotin.
Nabumetone The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Nabumetone.
Ketorolac The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Ketorolac.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Tenoxicam.
Celecoxib The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Celecoxib.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefotaxime.
Tolmetin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Tolmetin.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Rofecoxib.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Fenoprofen.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Valdecoxib.
Diclofenac The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Diclofenac.
Sulindac The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Sulindac.
Bacitracin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Bacitracin.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Amphotericin B.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cephaloglycin.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Adefovir dipivoxil.
Pentamidine The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Pentamidine.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Mefenamic acid.
Naproxen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Naproxen.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Sulfasalazine.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Phenylbutazone.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefmenoxime is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Carprofen.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Tacrolimus.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Etacrynic acid.
Ceforanide The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Ceforanide.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Salicylic acid.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Acetylsalicylic acid.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Hydrochlorothiazide.
Balsalazide The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Balsalazide.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefditoren.
Atazanavir The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Atazanavir.
Colistimethate The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Colistimethate.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefuroxime.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefapirin.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefprozil.
Olsalazine The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Lumiracoxib.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefamandole.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefazolin.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefonicid.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefoperazone.
Cefoxitin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefoxitin.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Ceftizoxime.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Magnesium salicylate.
Salsalate The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Choline magnesium trisalicylate.
Cefepime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefepime.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefacetrile.
Cefpodoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefpodoxime.
Antrafenine The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Antrafenine.
Aminophenazone The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Aminophenazone.
Antipyrine The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Antipyrine.
Tiaprofenic acid The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Tiaprofenic acid.
Lopinavir The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Lopinavir.
Etoricoxib The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Etoricoxib.
Hydrolyzed Cephalothin The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Hydrolyzed Cephalothin.
Cephalothin Group The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cephalothin Group.
Oxyphenbutazone The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Oxyphenbutazone.
Latamoxef The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Latamoxef.
Nimesulide The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Nimesulide.
Benoxaprofen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Benoxaprofen.
Metamizole The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Metamizole.
Zomepirac The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Zomepirac.
Ceftobiprole The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Ceftobiprole.
Cimicoxib The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cimicoxib.
Ceftaroline fosamil The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Ceftaroline fosamil.
Lornoxicam The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Lornoxicam.
Zaltoprofen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Zaltoprofen.
Azapropazone The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Azapropazone.
Parecoxib The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Parecoxib.
Salicylamide The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Salicylamide.
Kebuzone The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Kebuzone.
Isoxicam The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Isoxicam.
Indoprofen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Indoprofen.
Ibuproxam The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Ibuproxam.
Floctafenine The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Floctafenine.
Fenbufen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Fenbufen.
Etofenamate The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Etofenamate.
Epirizole The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Epirizole.
Cefaloridine The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefaloridine.
Cefminox The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefminox.
Dexibuprofen The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Dexibuprofen.
Droxicam The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Droxicam.

Target Protein

Peptidoglycan synthase FtsI ftsI
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Synthesis reference: Yasushi Morita, "Method for preventing coloration of aqueous preparations of cefmenoxime." U.S. Patent US4808577, issued November, 1985.
Artikel (PubMed)
  • PMID: 7637194
    Yokota N, Koguchi M, Suzuki Y, Fukayama S, Ishihara R, Deguchi K, Oda S, Tanaka S, Nakane Y, Fukumoto T: Antibacterial activities of cefmenoxime against recent fresh clinical isolates from patients in sinusitis. Jpn J Antibiot. 1995 May;48(5):602-9.
  • PMID: 8193431
    Paladino JA, Fell RE: Pharmacoeconomic analysis of cefmenoxime dual individualization in the treatment of nosocomial pneumonia. Ann Pharmacother. 1994 Mar;28(3):384-9.
  • PMID: 7816419
    Duncker GI, Reich U, Krausse R: Cefmenoxime in corneal organ culture. Ophthalmologica. 1994;208(5):262-6.
  • PMID: 6941742
    Tsuchiya K, Kondo M, Kida M, Nakao M, Iwahi T, Nishi T, Noji Y, Takeuchi M, Nozaki Y: Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1981 Jan;19(1):56-65.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Bestcall — Takeda
  • Cefmax
  • Tacef — Takeda

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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