Peringatan Keamanan

LD50=233 mg/kg (orally in mice); LD50=250 mg/kg (orally in rats)

Dicoumarol

DB00266

small molecule approved

Deskripsi

Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.

Struktur Molekul 2D

Berat 336.295
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include ginseng, ginkgo, ginger, and garlic.

Interaksi Obat

1476 Data
Apixaban Apixaban may increase the anticoagulant activities of Dicoumarol.
Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Dicoumarol.
Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Dicoumarol.
Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Dicoumarol is combined with Deferasirox.
Ursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Cholic Acid.
Glycocholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Taurocholic acid.
Obeticholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Dicoumarol is combined with Hyodeoxycholic Acid.
Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Dicoumarol.
Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Dicoumarol.
Obinutuzumab The risk or severity of bleeding and hemorrhage can be increased when Dicoumarol is combined with Obinutuzumab.
Rivaroxaban Dicoumarol may increase the anticoagulant activities of Rivaroxaban.
Sugammadex The risk or severity of bleeding and hemorrhage can be increased when Dicoumarol is combined with Sugammadex.
Tibolone Tibolone may increase the anticoagulant activities of Dicoumarol.
Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Dicoumarol.
Urokinase Urokinase may increase the anticoagulant activities of Dicoumarol.
Vitamin E Vitamin E may increase the anticoagulant activities of Dicoumarol.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Dicoumarol.
Aprotinin The therapeutic efficacy of Dicoumarol can be decreased when used in combination with Aprotinin.
Gemcitabine The therapeutic efficacy of Dicoumarol can be increased when used in combination with Gemcitabine.
Flunisolide Flunisolide may increase the anticoagulant activities of Dicoumarol.
Beclomethasone dipropionate Beclomethasone dipropionate may increase the anticoagulant activities of Dicoumarol.
Betamethasone Betamethasone may increase the anticoagulant activities of Dicoumarol.
Fluticasone propionate Fluticasone propionate may increase the anticoagulant activities of Dicoumarol.
Fluocinolone acetonide Fluocinolone acetonide may increase the anticoagulant activities of Dicoumarol.
Prednisone Prednisone may increase the anticoagulant activities of Dicoumarol.
Fludrocortisone Fludrocortisone may increase the anticoagulant activities of Dicoumarol.
Hydrocortisone Hydrocortisone may increase the anticoagulant activities of Dicoumarol.
Prednisolone Prednisolone may increase the anticoagulant activities of Dicoumarol.
Methylprednisolone Methylprednisolone may increase the anticoagulant activities of Dicoumarol.
Trilostane Trilostane may increase the anticoagulant activities of Dicoumarol.
Budesonide Budesonide may increase the anticoagulant activities of Dicoumarol.
Dexamethasone Dexamethasone may increase the anticoagulant activities of Dicoumarol.
Corticotropin Corticotropin may increase the anticoagulant activities of Dicoumarol.
Cortisone acetate Cortisone acetate may increase the anticoagulant activities of Dicoumarol.
Paramethasone Paramethasone may increase the anticoagulant activities of Dicoumarol.
Ciclesonide Ciclesonide may increase the anticoagulant activities of Dicoumarol.
Aldosterone Aldosterone may increase the anticoagulant activities of Dicoumarol.
Fluticasone furoate Fluticasone furoate may increase the anticoagulant activities of Dicoumarol.
Fluprednidene Fluprednidene may increase the anticoagulant activities of Dicoumarol.
Tixocortol Tixocortol may increase the anticoagulant activities of Dicoumarol.
Fluprednisolone Fluprednisolone may increase the anticoagulant activities of Dicoumarol.
Meprednisone Meprednisone may increase the anticoagulant activities of Dicoumarol.
Dexamethasone isonicotinate Dexamethasone isonicotinate may increase the anticoagulant activities of Dicoumarol.
Melengestrol Melengestrol may increase the anticoagulant activities of Dicoumarol.
Deflazacort Deflazacort may increase the anticoagulant activities of Dicoumarol.
Cortivazol Cortivazol may increase the anticoagulant activities of Dicoumarol.
Prednylidene Prednylidene may increase the anticoagulant activities of Dicoumarol.
Fluocortin Fluocortin may increase the anticoagulant activities of Dicoumarol.
Fluperolone Fluperolone may increase the anticoagulant activities of Dicoumarol.
Cloprednol Cloprednol may increase the anticoagulant activities of Dicoumarol.
Fluclorolone Fluclorolone may increase the anticoagulant activities of Dicoumarol.
Fluticasone Fluticasone may increase the anticoagulant activities of Dicoumarol.
Mometasone furoate Mometasone furoate may increase the anticoagulant activities of Dicoumarol.
Hydrocortisone acetate Hydrocortisone acetate may increase the anticoagulant activities of Dicoumarol.
Hydrocortisone cypionate Hydrocortisone cypionate may increase the anticoagulant activities of Dicoumarol.
Hydrocortisone succinate Hydrocortisone succinate may increase the anticoagulant activities of Dicoumarol.
Prednisolone phosphate Prednisolone phosphate may increase the anticoagulant activities of Dicoumarol.
Prednisolone hemisuccinate Prednisolone hemisuccinate may increase the anticoagulant activities of Dicoumarol.
Methylprednisolone hemisuccinate Methylprednisolone hemisuccinate may increase the anticoagulant activities of Dicoumarol.
Prednisone acetate Prednisone acetate may increase the anticoagulant activities of Dicoumarol.
Clocortolone acetate Clocortolone acetate may increase the anticoagulant activities of Dicoumarol.
Melengestrol acetate Melengestrol acetate may increase the anticoagulant activities of Dicoumarol.
Betamethasone phosphate Betamethasone phosphate may increase the anticoagulant activities of Dicoumarol.
Cortisone Cortisone may increase the anticoagulant activities of Dicoumarol.
Clobetasol propionate Clobetasol propionate may increase the anticoagulant activities of Dicoumarol.
Fluocinonide Fluocinonide may increase the anticoagulant activities of Dicoumarol.
Hydrocortisone butyrate Hydrocortisone butyrate may increase the anticoagulant activities of Dicoumarol.
Desoximetasone Desoximetasone may increase the anticoagulant activities of Dicoumarol.
Mometasone Mometasone may increase the anticoagulant activities of Dicoumarol.
Fluocortolone Fluocortolone may increase the anticoagulant activities of Dicoumarol.
Prednisolone acetate Prednisolone acetate may increase the anticoagulant activities of Dicoumarol.
Fluorometholone Fluorometholone may increase the anticoagulant activities of Dicoumarol.
Difluocortolone Difluocortolone may increase the anticoagulant activities of Dicoumarol.
Flumethasone Flumethasone may increase the anticoagulant activities of Dicoumarol.
Methylprednisolone aceponate Methylprednisolone aceponate may increase the anticoagulant activities of Dicoumarol.
Erlotinib The serum concentration of Dicoumarol can be increased when it is combined with Erlotinib.
Acetaminophen Acetaminophen may increase the anticoagulant activities of Dicoumarol.
Azathioprine The therapeutic efficacy of Dicoumarol can be decreased when used in combination with Azathioprine.
Chloral hydrate The protein binding of Dicoumarol can be decreased when combined with Chloral hydrate.
Methylphenidate The metabolism of Dicoumarol can be decreased when combined with Methylphenidate.
Disulfiram Disulfiram may increase the anticoagulant activities of Dicoumarol.
Etacrynic acid The protein binding of Dicoumarol can be decreased when combined with Etacrynic acid.
Ethotoin The therapeutic efficacy of Dicoumarol can be increased when used in combination with Ethotoin.
Etoposide The therapeutic efficacy of Dicoumarol can be increased when used in combination with Etoposide.
Exenatide Exenatide can cause an increase in the absorption of Dicoumarol resulting in an increased serum concentration and potentially a worsening of adverse effects.
Gefitinib Gefitinib may increase the anticoagulant activities of Dicoumarol.
Ginkgo biloba Ginkgo biloba may increase the anticoagulant activities of Dicoumarol.
Glutethimide The therapeutic efficacy of Dicoumarol can be decreased when used in combination with Glutethimide.
Ifosfamide The risk or severity of bleeding can be increased when Ifosfamide is combined with Dicoumarol.
Teriflunomide The therapeutic efficacy of Dicoumarol can be increased when used in combination with Teriflunomide.

Target Protein

Vitamin K epoxide reductase complex subunit 1 VKORC1
NAD(P)H dehydrogenase [quinone] 1 NQO1
Quinone oxidoreductase CRYZ

Referensi & Sumber

Artikel (PubMed)
  • PMID: 14500388
    Cullen JJ, Hinkhouse MM, Grady M, Gaut AW, Liu J, Zhang YP, Weydert CJ, Domann FE, Oberley LW: Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Res. 2003 Sep 1;63(17):5513-20.
  • PMID: 15511084
    Mironov AA, Colanzi A, Polishchuk RS, Beznoussenko GV, Mironov AA Jr, Fusella A, Di Tullio G, Silletta MG, Corda D, De Matteis MA, Luini A: Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport. Eur J Cell Biol. 2004 Jul;83(6):263-79.
  • PMID: 15639223
    Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz LO: Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication. Arch Biochem Biophys. 2005 Feb 15;434(2):241-7.
  • PMID: 12880296
    Thanos CG, Liu Z, Reineke J, Edwards E, Mathiowitz E: Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride. Pharm Res. 2003 Jul;20(7):1093-100.

Contoh Produk & Brand

Produk: 0 • International brands: 0
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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