Peringatan Keamanan

Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.

Cycloserine

DB00260

small molecule approved

Deskripsi

Antibiotic substance produced by Streptomyces garyphalus.

Struktur Molekul 2D

Berat 102.0919
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Do not take with or immediately after a high-fat meal. High-fat meals may reduce the rate of absorption; however, the impact on the extent of absorption is unknown.

Interaksi Obat

199 Data
Ethionamide The risk or severity of adverse effects can be increased when Ethionamide is combined with Cycloserine.
Isoniazid The risk or severity of adverse effects can be increased when Isoniazid is combined with Cycloserine.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cycloserine.
Ethanol Ethanol may increase the neurotoxic activities of Cycloserine.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Cycloserine.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Cycloserine.
Dicoumarol The risk or severity of bleeding can be increased when Cycloserine is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Cycloserine is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Cycloserine is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Cycloserine is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Cycloserine is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Cycloserine is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Cycloserine is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Cycloserine is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Cycloserine is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Cycloserine is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Cycloserine is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Cycloserine is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Cycloserine is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Cycloserine is combined with (S)-Warfarin.
Cyclosporine Cyclosporine may increase the neurotoxic activities of Cycloserine.
Succinylcholine Succinylcholine may increase the neurotoxic activities of Cycloserine.
Reserpine Reserpine may increase the neurotoxic activities of Cycloserine.
Ziprasidone Ziprasidone may increase the neurotoxic activities of Cycloserine.
Amitriptyline Cycloserine may increase the neurotoxic activities of Amitriptyline.
Protriptyline Cycloserine may increase the neurotoxic activities of Protriptyline.
Vinorelbine Cycloserine may increase the neurotoxic activities of Vinorelbine.
Clozapine Cycloserine may increase the neurotoxic activities of Clozapine.
Thiethylperazine Cycloserine may increase the neurotoxic activities of Thiethylperazine.
Sulpiride Cycloserine may increase the neurotoxic activities of Sulpiride.
Loxapine Cycloserine may increase the neurotoxic activities of Loxapine.
Remoxipride Cycloserine may increase the neurotoxic activities of Remoxipride.
Promazine Cycloserine may increase the neurotoxic activities of Promazine.
Prochlorperazine Cycloserine may increase the neurotoxic activities of Prochlorperazine.
Teniposide Cycloserine may increase the neurotoxic activities of Teniposide.
Droperidol Cycloserine may increase the neurotoxic activities of Droperidol.
Imipramine Cycloserine may increase the neurotoxic activities of Imipramine.
Chlorpromazine Cycloserine may increase the neurotoxic activities of Chlorpromazine.
Haloperidol Cycloserine may increase the neurotoxic activities of Haloperidol.
Triflupromazine Cycloserine may increase the neurotoxic activities of Triflupromazine.
Cyclophosphamide Cycloserine may increase the neurotoxic activities of Cyclophosphamide.
Nortriptyline Cycloserine may increase the neurotoxic activities of Nortriptyline.
Vincristine Cycloserine may increase the neurotoxic activities of Vincristine.
Amoxapine Cycloserine may increase the neurotoxic activities of Amoxapine.
Fluphenazine Cycloserine may increase the neurotoxic activities of Fluphenazine.
Stavudine Cycloserine may increase the neurotoxic activities of Stavudine.
Thioridazine Cycloserine may increase the neurotoxic activities of Thioridazine.
Moricizine Cycloserine may increase the neurotoxic activities of Moricizine.
Trimipramine Cycloserine may increase the neurotoxic activities of Trimipramine.
Risperidone Cycloserine may increase the neurotoxic activities of Risperidone.
Trifluoperazine Cycloserine may increase the neurotoxic activities of Trifluoperazine.
Perphenazine Cycloserine may increase the neurotoxic activities of Perphenazine.
Flupentixol Cycloserine may increase the neurotoxic activities of Flupentixol.
Didanosine Cycloserine may increase the neurotoxic activities of Didanosine.
Cyclobenzaprine Cycloserine may increase the neurotoxic activities of Cyclobenzaprine.
Mesoridazine Cycloserine may increase the neurotoxic activities of Mesoridazine.
Acetophenazine Cycloserine may increase the neurotoxic activities of Acetophenazine.
Promethazine Cycloserine may increase the neurotoxic activities of Promethazine.
Pimozide Cycloserine may increase the neurotoxic activities of Pimozide.
Doxepin Cycloserine may increase the neurotoxic activities of Doxepin.
Desipramine Cycloserine may increase the neurotoxic activities of Desipramine.
Clindamycin Cycloserine may increase the neurotoxic activities of Clindamycin.
Tubocurarine Cycloserine may increase the neurotoxic activities of Tubocurarine.
Paclitaxel Cycloserine may increase the neurotoxic activities of Paclitaxel.
Aripiprazole Cycloserine may increase the neurotoxic activities of Aripiprazole.
Chlorprothixene Cycloserine may increase the neurotoxic activities of Chlorprothixene.
Clomipramine Cycloserine may increase the neurotoxic activities of Clomipramine.
Decamethonium Cycloserine may increase the neurotoxic activities of Decamethonium.
Alimemazine Cycloserine may increase the neurotoxic activities of Alimemazine.
Paliperidone Cycloserine may increase the neurotoxic activities of Paliperidone.
Lithium cation Cycloserine may increase the neurotoxic activities of Lithium cation.
Methotrimeprazine Cycloserine may increase the neurotoxic activities of Methotrimeprazine.
Imipenem Cycloserine may increase the neurotoxic activities of Imipenem.
Periciazine Cycloserine may increase the neurotoxic activities of Periciazine.
Acepromazine Cycloserine may increase the neurotoxic activities of Acepromazine.
Aceprometazine Cycloserine may increase the neurotoxic activities of Aceprometazine.
Molindone Cycloserine may increase the neurotoxic activities of Molindone.
Pipotiazine Cycloserine may increase the neurotoxic activities of Pipotiazine.
Thioproperazine Cycloserine may increase the neurotoxic activities of Thioproperazine.
Thiothixene Cycloserine may increase the neurotoxic activities of Thiothixene.
Zuclopenthixol Cycloserine may increase the neurotoxic activities of Zuclopenthixol.
Lincomycin Cycloserine may increase the neurotoxic activities of Lincomycin.
Amineptine Cycloserine may increase the neurotoxic activities of Amineptine.
Fluspirilene Cycloserine may increase the neurotoxic activities of Fluspirilene.
Osanetant Cycloserine may increase the neurotoxic activities of Osanetant.
Bifeprunox Cycloserine may increase the neurotoxic activities of Bifeprunox.
Iloperidone Cycloserine may increase the neurotoxic activities of Iloperidone.
Pimavanserin Cycloserine may increase the neurotoxic activities of Pimavanserin.
BL-1020 Cycloserine may increase the neurotoxic activities of BL-1020.
Cariprazine Cycloserine may increase the neurotoxic activities of Cariprazine.
Sertindole Cycloserine may increase the neurotoxic activities of Sertindole.
Asenapine Cycloserine may increase the neurotoxic activities of Asenapine.
Amisulpride Cycloserine may increase the neurotoxic activities of Amisulpride.
Lurasidone Cycloserine may increase the neurotoxic activities of Lurasidone.
Perospirone Cycloserine may increase the neurotoxic activities of Perospirone.
Amperozide Cycloserine may increase the neurotoxic activities of Amperozide.
Dimetacrine Cycloserine may increase the neurotoxic activities of Dimetacrine.
Cyamemazine Cycloserine may increase the neurotoxic activities of Cyamemazine.
Butriptyline Cycloserine may increase the neurotoxic activities of Butriptyline.
Brexpiprazole Cycloserine may increase the neurotoxic activities of Brexpiprazole.

Target Protein

Glutamate receptor ionotropic, NMDA 1 GRIN1
D-alanine--D-alanine ligase A ddlA
Alanine racemase alr

Referensi & Sumber

Synthesis reference: Norman P. Jensen, "N-substituted cycloserine compounds, salts thereof, and processes for preparing them." U.S. Patent US3932439, issued December, 1956.

Contoh Produk & Brand

Produk: 9 • International brands: 2
Produk
  • Cycloserine
    Capsule • 250 mg/1 • Oral • US
  • Cycloserine
    Capsule • 250 mg/250mg • Oral • US • Generic • Approved
  • Cycloserine
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Cycloserine
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Seromycin
    Capsule • 250 mg/1 • Oral • US • Approved
  • Seromycin
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Seromycin
    Capsule • 250 mg/250mg • Oral • US • Generic • Approved
  • Seromycin
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 9 produk.
International Brands
  • Oxamycin — Merck
  • Tisomycin — Lilly

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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