Few cases of acute methysergide intoxication have been reported. The possible symptom complex is therefore not fully known. The following symptoms are based on these few case reports. Euphoria, hyperactivity, tachycardia, dilated pupils, and dizziness have been reported in a child with a dose of 20-24 mg of methysergide. In adults, peripheral vasospasm, with diminished or absent pulses, coldness, mottling and cyanosis, has been observed at a dose of 200 mg. Ischemic tissue damage has not been reported in acute overdosage with methysergide.
An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Phenytoin | The metabolism of Methysergide can be increased when combined with Phenytoin. |
| Fosphenytoin | The metabolism of Methysergide can be increased when combined with Fosphenytoin. |
| Valsartan | Methysergide may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Methysergide may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Methysergide may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Methysergide may decrease the antihypertensive activities of Torasemide. |
| Guanadrel | Methysergide may decrease the antihypertensive activities of Guanadrel. |
| Olmesartan | Methysergide may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Methysergide may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Methysergide may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Methysergide may decrease the antihypertensive activities of Minoxidil. |
| Treprostinil | Methysergide may decrease the antihypertensive activities of Treprostinil. |
| Bendroflumethiazide | Methysergide may decrease the antihypertensive activities of Bendroflumethiazide. |
| Prazosin | Methysergide may decrease the antihypertensive activities of Prazosin. |
| Fosinopril | Methysergide may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Methysergide may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Methysergide may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Methysergide may decrease the antihypertensive activities of Benazepril. |
| Cyclothiazide | Methysergide may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Methysergide may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Methysergide may decrease the antihypertensive activities of Mecamylamine. |
| Moexipril | Methysergide may decrease the antihypertensive activities of Moexipril. |
| Lisinopril | Methysergide may decrease the antihypertensive activities of Lisinopril. |
| Hydroflumethiazide | Methysergide may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Methysergide may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Methysergide may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Methysergide may decrease the antihypertensive activities of Candesartan cilexetil. |
| Fenoldopam | Methysergide may decrease the antihypertensive activities of Fenoldopam. |
| Eprosartan | Methysergide may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Methysergide may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Methysergide may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Methysergide may decrease the antihypertensive activities of Telmisartan. |
| Hydrochlorothiazide | Methysergide may decrease the antihypertensive activities of Hydrochlorothiazide. |
| Trichlormethiazide | Methysergide may decrease the antihypertensive activities of Trichlormethiazide. |
| Deserpidine | Methysergide may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Methysergide may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Methysergide may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Methysergide may decrease the antihypertensive activities of Diazoxide. |
| Bretylium | Methysergide may decrease the antihypertensive activities of Bretylium. |
| Terazosin | Methysergide may decrease the antihypertensive activities of Terazosin. |
| Captopril | Methysergide may decrease the antihypertensive activities of Captopril. |
| Epoprostenol | Methysergide may decrease the antihypertensive activities of Epoprostenol. |
| Polythiazide | Methysergide may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Methysergide may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Methysergide may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Methysergide may decrease the antihypertensive activities of Spirapril. |
| Tienilic acid | Methysergide may decrease the antihypertensive activities of Tienilic acid. |
| Debrisoquine | Methysergide may decrease the antihypertensive activities of Debrisoquine. |
| Diethylnorspermine | Methysergide may decrease the antihypertensive activities of Diethylnorspermine. |
| Temocapril | Methysergide may decrease the antihypertensive activities of Temocapril. |
| Trimazosin | Methysergide may decrease the antihypertensive activities of Trimazosin. |
| Nicorandil | Methysergide may decrease the antihypertensive activities of Nicorandil. |
| Rauwolfia serpentina root | Methysergide may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Methysergide may decrease the antihypertensive activities of Enalaprilat. |
| Angiotensin 1-7 | Methysergide may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Methysergide may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Methysergide may decrease the antihypertensive activities of BQ-123. |
| Cicletanine | Methysergide may decrease the antihypertensive activities of Cicletanine. |
| Dihydralazine | Methysergide may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Methysergide may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Methysergide may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Methysergide may decrease the antihypertensive activities of Delapril. |
| Vincamine | Methysergide may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Methysergide may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Methysergide may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Methysergide may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Methysergide may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Methysergide may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Methysergide may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Methysergide may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Methysergide may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Methysergide may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Methysergide may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Methysergide may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Methysergide may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Methysergide may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Methysergide may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Methysergide may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Methysergide may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Methysergide may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Methysergide may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Methysergide may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Methysergide may decrease the antihypertensive activities of Furosemide. |
| Enalapril | Methysergide may decrease the antihypertensive activities of Enalapril. |
| Amlodipine | Methysergide may decrease the antihypertensive activities of Amlodipine. |
| Nimodipine | Methysergide may decrease the antihypertensive activities of Nimodipine. |
| Lercanidipine | Methysergide may decrease the antihypertensive activities of Lercanidipine. |
| Indapamide | Methysergide may decrease the antihypertensive activities of Indapamide. |
| Nitrendipine | Methysergide may decrease the antihypertensive activities of Nitrendipine. |
| Guanethidine | Methysergide may decrease the antihypertensive activities of Guanethidine. |
| Bepridil | Methysergide may decrease the antihypertensive activities of Bepridil. |
| Ambrisentan | Methysergide may decrease the antihypertensive activities of Ambrisentan. |
| Pinacidil | Methysergide may decrease the antihypertensive activities of Pinacidil. |
| Riociguat | Methysergide may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Methysergide may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Methysergide may decrease the antihypertensive activities of Aliskiren. |
| Lacidipine | Methysergide may decrease the antihypertensive activities of Lacidipine. |
| Niguldipine | Methysergide may decrease the antihypertensive activities of Niguldipine. |
| Selexipag | Methysergide may decrease the antihypertensive activities of Selexipag. |
| Naftopidil | Methysergide may decrease the antihypertensive activities of Naftopidil. |