Peringatan Keamanan

Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.

Oxiconazole

DB00239

small molecule approved

Deskripsi

Oxiconazole is an antifungal agent that is commonly found in topical formulations. It is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin infections such as athlete's foot, jock itch and ringworm.

Struktur Molekul 2D

Berat 429.12
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Systemic absorption of oxiconazole is low.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

14 Data
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Oxiconazole.
Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Oxiconazole.
Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Oxiconazole.
Ranolazine The metabolism of Ranolazine can be increased when combined with Oxiconazole.
Clindamycin The metabolism of Clindamycin can be increased when combined with Oxiconazole.
Rimegepant The metabolism of Rimegepant can be increased when combined with Oxiconazole.
Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Oxiconazole.
Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Oxiconazole.
Oliceridine The serum concentration of Oliceridine can be decreased when it is combined with Oxiconazole.
Tivozanib The metabolism of Tivozanib can be increased when combined with Oxiconazole.
Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Oxiconazole.
Clozapine The serum concentration of Clozapine can be decreased when it is combined with Oxiconazole.
Doxorubicin The serum concentration of Doxorubicin can be decreased when it is combined with Oxiconazole.
Zuranolone The serum concentration of Zuranolone can be decreased when it is combined with Oxiconazole.

Target Protein

Lanosterol 14-alpha demethylase ERG11
Lanosterol synthase ERG7
Nuclear receptor subfamily 1 group I member 2 NR1I2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18468760
    Matsui H, Sakanashi Y, Oyama TM, Oyama Y, Yokota S, Ishida S, Okano Y, Oyama TB, Nishimura Y: Imidazole antifungals, but not triazole antifungals, increase membrane Zn2+ permeability in rat thymocytes Possible contribution to their cytotoxicity. Toxicology. 2008 Jun 27;248(2-3):142-50. doi: 10.1016/j.tox.2008.03.022. Epub 2008 Apr 7.
  • PMID: 3069196
    Fromtling RA: Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988 Apr;1(2):187-217.

Contoh Produk & Brand

Produk: 13 • International brands: 0
Produk
  • Oxiconazole Nitrate
    Cream • 10 mg/1g • Topical • US • Generic • Approved
  • Oxiconazole Nitrate
    Cream • 10 mg/1g • Topical • US • Generic • Approved
  • Oxiconazole Nitrate Cream 1%
    Cream • 10 mg/1g • Topical • US • Generic • Approved
  • Oxistat
    Lotion • 30 mg/1g • Topical • US • Approved
  • Oxistat
    Lotion • 10 mg/1mL • Topical • US • Approved
  • Oxistat
    Cream • 10 mg/1g • Topical • US • Approved
  • Oxistat
    Cream • 10 mg/1g • Topical • US • Approved
  • Oxistat
    Lotion • 10 mg/1g • Topical • US • Approved
Menampilkan 8 dari 13 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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