Peringatan Keamanan

Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease. The most common adverse reaction is rash.

Nevirapine

DB00238

small molecule approved

Deskripsi

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.

Struktur Molekul 2D

Berat 266.2979
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 45 hours
Volume Distribusi * 1.21 ± 0.09 L/kg [apparent volume of distribution, healthy adults, IV] Nevirapine is capable of crossing the placenta and is found in breast milk.
Klirens (Clearance) -

Absorpsi

Nevirapine is readily absorbed (greater than 90%) after oral administration in healthy subjects and adults with HIV-1 infection. The absolute bioavailability in healthy adults following a single dose administration is 93 ± 9% (mean ± SD) for a 50 mg tablet and 91 ± 8% for an oral solution. Peak plasma nevirapine concentrations of 2 ± 0.4 mcg/mL (7.5 micromolar) were attained by 4 hours following a single 200 mg dose. Nevirapine tablets and suspension have been shown to be comparably bioavailable and interchangeable at doses up to 200 mg. When the oral tablet is given with a high-fat meal, the extent of absorption is compared to that of the fasted-state.

Metabolisme

Hepatic. In vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome P450 3A4 metabolism to several hydroxylated metabolites.

Rute Eliminasi

Thus cytochrome P450 metabolism, glucuronide conjugation, and urinary excretion of glucuronidated metabolites represent the primary route of nevirapine biotransformation and elimination in humans. Only a small fraction (<5%) of the radioactivity in urine (representing <3% of the total dose) was made up of parent compound; therefore, renal excretion plays a minor role in elimination of the parent compound.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

870 Data
Tizanidine The serum concentration of Tizanidine can be increased when it is combined with Nevirapine.
Fluconazole The serum concentration of Nevirapine can be increased when it is combined with Fluconazole.
Indinavir The serum concentration of Indinavir can be decreased when it is combined with Nevirapine.
Darunavir The serum concentration of Nevirapine can be increased when it is combined with Darunavir.
Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Nevirapine.
Itraconazole The serum concentration of Itraconazole can be decreased when it is combined with Nevirapine.
Lopinavir The serum concentration of Lopinavir can be decreased when it is combined with Nevirapine.
Rifabutin The serum concentration of Rifabutin can be decreased when it is combined with Nevirapine.
Saquinavir The serum concentration of Saquinavir can be decreased when it is combined with Nevirapine.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Nevirapine.
Rifampin The metabolism of Nevirapine can be increased when combined with Rifampicin.
Mirabegron The serum concentration of Nevirapine can be increased when it is combined with Mirabegron.
Tranylcypromine The metabolism of Nevirapine can be decreased when combined with Tranylcypromine.
Cyclosporine The metabolism of Nevirapine can be decreased when combined with Cyclosporine.
Imipramine The metabolism of Nevirapine can be decreased when combined with Imipramine.
Darifenacin The metabolism of Nevirapine can be decreased when combined with Darifenacin.
Desipramine The metabolism of Nevirapine can be decreased when combined with Desipramine.
Dosulepin The metabolism of Nevirapine can be decreased when combined with Dosulepin.
Cimetidine The metabolism of Nevirapine can be decreased when combined with Cimetidine.
Nicardipine The metabolism of Nevirapine can be decreased when combined with Nicardipine.
Sulfaphenazole The metabolism of Nevirapine can be decreased when combined with Sulfaphenazole.
Rhein The metabolism of Nevirapine can be decreased when combined with Rhein.
Cholecalciferol The metabolism of Nevirapine can be decreased when combined with Cholecalciferol.
Fluvoxamine The metabolism of Nevirapine can be decreased when combined with Fluvoxamine.
Metoprolol The metabolism of Nevirapine can be decreased when combined with Metoprolol.
Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Nevirapine.
Clobazam The serum concentration of Nevirapine can be increased when it is combined with Clobazam.
Clozapine The serum concentration of Clozapine can be increased when it is combined with Nevirapine.
Quinine The metabolism of Nevirapine can be decreased when combined with Quinine.
Duloxetine The metabolism of Nevirapine can be decreased when combined with Duloxetine.
Chlorpromazine The metabolism of Nevirapine can be decreased when combined with Chlorpromazine.
Celecoxib The metabolism of Nevirapine can be decreased when combined with Celecoxib.
Chloroquine The metabolism of Nevirapine can be decreased when combined with Chloroquine.
Terbinafine The metabolism of Nevirapine can be decreased when combined with Terbinafine.
Perhexiline The metabolism of Nevirapine can be decreased when combined with Perhexiline.
Primaquine The metabolism of Nevirapine can be decreased when combined with Primaquine.
Fusidic acid The metabolism of Nevirapine can be decreased when combined with Fusidic acid.
Panobinostat The metabolism of Nevirapine can be decreased when combined with Panobinostat.
Lumefantrine The metabolism of Nevirapine can be decreased when combined with Lumefantrine.
Manidipine The metabolism of Nevirapine can be decreased when combined with Manidipine.
Rolapitant The metabolism of Nevirapine can be decreased when combined with Rolapitant.
Asunaprevir The metabolism of Nevirapine can be decreased when combined with Asunaprevir.
Rucaparib The metabolism of Nevirapine can be decreased when combined with Rucaparib.
Tegaserod The metabolism of Nevirapine can be decreased when combined with Tegaserod.
Phenylbutyric acid The metabolism of Nevirapine can be decreased when combined with Phenylbutyric acid.
Ritanserin The metabolism of Nevirapine can be decreased when combined with Ritanserin.
Abiraterone The metabolism of Nevirapine can be decreased when combined with Abiraterone.
Vilazodone The metabolism of Nevirapine can be decreased when combined with Vilazodone.
Lorcaserin The metabolism of Nevirapine can be decreased when combined with Lorcaserin.
Berotralstat The metabolism of Nevirapine can be decreased when combined with Berotralstat.
Glycerol phenylbutyrate The metabolism of Nevirapine can be decreased when combined with Glycerol phenylbutyrate.
Thioridazine The metabolism of Nevirapine can be decreased when combined with Thioridazine.
Methotrimeprazine The metabolism of Nevirapine can be decreased when combined with Methotrimeprazine.
Paroxetine The metabolism of Nevirapine can be decreased when combined with Paroxetine.
Cinacalcet The metabolism of Nevirapine can be decreased when combined with Cinacalcet.
Propafenone The metabolism of Nevirapine can be decreased when combined with Propafenone.
Halofantrine The metabolism of Nevirapine can be decreased when combined with Halofantrine.
Troglitazone The metabolism of Nevirapine can be decreased when combined with Troglitazone.
Nabilone The metabolism of Nabilone can be decreased when combined with Nevirapine.
Iproniazid The metabolism of Nevirapine can be decreased when combined with Iproniazid.
Imatinib The serum concentration of Nevirapine can be increased when it is combined with Imatinib.
Felbamate The metabolism of Nevirapine can be decreased when combined with Felbamate.
Sulfinpyrazone The metabolism of Nevirapine can be decreased when combined with Sulfinpyrazone.
Medical Cannabis The metabolism of Nevirapine can be decreased when combined with Medical Cannabis.
Dabrafenib The serum concentration of Nevirapine can be decreased when it is combined with Dabrafenib.
Floxuridine The metabolism of Nevirapine can be decreased when combined with Floxuridine.
Miconazole The metabolism of Nevirapine can be decreased when combined with Miconazole.
Gemfibrozil The metabolism of Nevirapine can be decreased when combined with Gemfibrozil.
Pentobarbital The metabolism of Nevirapine can be increased when combined with Pentobarbital.
Letrozole The metabolism of Nevirapine can be decreased when combined with Letrozole.
Pitolisant The serum concentration of Nevirapine can be decreased when it is combined with Pitolisant.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Nevirapine.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Nevirapine.
Metreleptin The metabolism of Nevirapine can be increased when combined with Metreleptin.
Ciprofloxacin The metabolism of Nevirapine can be decreased when combined with Ciprofloxacin.
Erythromycin The serum concentration of Nevirapine can be increased when it is combined with Erythromycin.
Fluticasone propionate The metabolism of Nevirapine can be decreased when combined with Fluticasone propionate.
Mibefradil The metabolism of Nevirapine can be decreased when combined with Mibefradil.
Gestodene The metabolism of Nevirapine can be decreased when combined with Gestodene.
Fluticasone furoate The metabolism of Fluticasone furoate can be decreased when combined with Nevirapine.
Fluticasone The metabolism of Nevirapine can be decreased when combined with Fluticasone.
Nabiximols The metabolism of Nevirapine can be decreased when combined with Nabiximols.
Curcumin sulfate The metabolism of Nevirapine can be decreased when combined with Curcumin sulfate.
Methylene blue The metabolism of Nevirapine can be decreased when combined with Methylene blue.
Clofazimine The metabolism of Nevirapine can be decreased when combined with Clofazimine.
Pralsetinib The metabolism of Nevirapine can be decreased when combined with Pralsetinib.
Aprepitant The metabolism of Nevirapine can be decreased when combined with Aprepitant.
Levoketoconazole The metabolism of Nevirapine can be decreased when combined with Levoketoconazole.
Acalabrutinib The metabolism of Nevirapine can be decreased when combined with Acalabrutinib.
Icotinib The metabolism of Nevirapine can be increased when combined with Icotinib.
Budesonide The metabolism of Nevirapine can be increased when combined with Budesonide.
Dexamethasone acetate The metabolism of Nevirapine can be increased when combined with Dexamethasone acetate.
Reserpine The metabolism of Nevirapine can be increased when combined with Reserpine.
Thalidomide The metabolism of Thalidomide can be increased when combined with Nevirapine.
Armodafinil The metabolism of Nevirapine can be increased when combined with Armodafinil.
Oxcarbazepine The metabolism of Nevirapine can be increased when combined with Oxcarbazepine.
Beclomethasone dipropionate The metabolism of Nevirapine can be increased when combined with Beclomethasone dipropionate.
Triamcinolone The metabolism of Nevirapine can be increased when combined with Triamcinolone.
Daunorubicin The metabolism of Nevirapine can be increased when combined with Daunorubicin.
Cortisone acetate The metabolism of Nevirapine can be increased when combined with Cortisone acetate.

Target Protein

Gag-Pol polyprotein gag-pol
Reverse transcriptase/RNaseH pol

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 68 • International brands: 0
Produk
  • Apo-nevirapine
    Tablet • 200 mg • Oral • Canada • Generic • Approved
  • Apo-nevirapine XR
    Tablet, extended release • 400 mg • Oral • Canada • Generic • Approved
  • Apo-zidovudine-lamivudine-nevirapine
    Tablet • - • Oral • Canada • Generic • Approved
  • Auro-nevirapine
    Tablet • 200 mg • Oral • Canada • Generic • Approved
  • Jamp Nevirapine
    Tablet • 200 mg • Oral • Canada • Generic • Approved
  • Lamivudine, Nevirapine, and Zidovudine
    Tablet, film coated • - • Oral • US • Approved
  • Mylan-nevirapine
    Tablet • 200 mg • Oral • Canada • Generic • Approved
  • Nevirapine
    Tablet • 200 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 68 produk.

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