Acute oral toxicity (LD50): >4000 mg/kg Rat. Symptoms of overdosage include electrolyte imbalance and signs of potassium deficiency such as confusion, dizziness, muscular weakness, and gastrointestinal disturbances.
A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Methyclothiazide is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Methyclothiazide is combined with Levodopa. |
| Risperidone | Methyclothiazide may increase the hypotensive activities of Risperidone. |
| Forasartan | Methyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Forasartan. |
| Tasosartan | Methyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Tasosartan. |
| Saralasin | Methyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Saralasin. |
| Fimasartan | Methyclothiazide may increase the hypotensive and Electrolyte Disturbance activities of Fimasartan. |
| Nicotine | The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Nicotine. |
| Cyclopentamine | The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Cyclopentamine. |
| Allopurinol | The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Methyclothiazide. |
| Carbamazepine | The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Carbamazepine. |
| Cyclophosphamide | The risk or severity of granulocytopenia can be increased when Methyclothiazide is combined with Cyclophosphamide. |
| Diazoxide | The risk or severity of hypotension, hyperglycemia, and hyperuricemia can be increased when Methyclothiazide is combined with Diazoxide. |
| Dofetilide | The risk or severity of QTc prolongation can be increased when Methyclothiazide is combined with Dofetilide. |
| Ivabradine | The risk or severity of Cardiac Arrhythmia can be increased when Methyclothiazide is combined with Ivabradine. |
| Lithium citrate | Methyclothiazide may decrease the excretion rate of Lithium citrate which could result in a higher serum level. |
| Lithium carbonate | Methyclothiazide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. |
| Lithium hydroxide | Methyclothiazide may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level. |
| Oxcarbazepine | The risk or severity of hyponatremia can be increased when Methyclothiazide is combined with Oxcarbazepine. |
| Topiramate | The risk or severity of hypokalemia can be increased when Methyclothiazide is combined with Topiramate. |
| Toremifene | The risk or severity of hypercalcemia can be increased when Methyclothiazide is combined with Toremifene. |
| Methotrexate | The protein binding of Methotrexate can be increased when combined with Methyclothiazide. |
| Sulpiride | The risk or severity of orthostatic hypotension can be increased when Methyclothiazide is combined with Sulpiride. |
| Aripiprazole | Aripiprazole may increase the hypotensive activities of Methyclothiazide. |
| Aripiprazole lauroxil | Aripiprazole lauroxil may increase the hypotensive activities of Methyclothiazide. |
| Nicorandil | Nicorandil may increase the hypotensive activities of Methyclothiazide. |
| Insulin human | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin human. |
| Insulin lispro | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin lispro. |
| Insulin glargine | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin glargine. |
| Insulin pork | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin pork. |
| Troglitazone | The therapeutic efficacy of Troglitazone can be decreased when used in combination with Methyclothiazide. |
| Glimepiride | The therapeutic efficacy of Glimepiride can be decreased when used in combination with Methyclothiazide. |
| Sulfisoxazole | The therapeutic efficacy of Sulfisoxazole can be decreased when used in combination with Methyclothiazide. |
| Disopyramide | The therapeutic efficacy of Disopyramide can be decreased when used in combination with Methyclothiazide. |
| Acarbose | The therapeutic efficacy of Acarbose can be decreased when used in combination with Methyclothiazide. |
| Sulfadiazine | The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Methyclothiazide. |
| Rosiglitazone | The therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Methyclothiazide. |
| Acetohexamide | The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Methyclothiazide. |
| Quinine | The therapeutic efficacy of Quinine can be decreased when used in combination with Methyclothiazide. |
| Miglitol | The therapeutic efficacy of Miglitol can be decreased when used in combination with Methyclothiazide. |
| Chlorpropamide | The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Methyclothiazide. |
| Nateglinide | The therapeutic efficacy of Nateglinide can be decreased when used in combination with Methyclothiazide. |
| Pentamidine | The therapeutic efficacy of Pentamidine can be decreased when used in combination with Methyclothiazide. |
| Mifepristone | The therapeutic efficacy of Mifepristone can be decreased when used in combination with Methyclothiazide. |
| Tolazamide | The therapeutic efficacy of Tolazamide can be decreased when used in combination with Methyclothiazide. |
| Repaglinide | The therapeutic efficacy of Repaglinide can be decreased when used in combination with Methyclothiazide. |
| Phenformin | The therapeutic efficacy of Phenformin can be decreased when used in combination with Methyclothiazide. |
| Sulfamethoxazole | The therapeutic efficacy of Sulfamethoxazole can be decreased when used in combination with Methyclothiazide. |
| Glyburide | The therapeutic efficacy of Glyburide can be decreased when used in combination with Methyclothiazide. |
| Glipizide | The therapeutic efficacy of Glipizide can be decreased when used in combination with Methyclothiazide. |
| Gliclazide | The therapeutic efficacy of Gliclazide can be decreased when used in combination with Methyclothiazide. |
| Tolbutamide | The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Methyclothiazide. |
| Pioglitazone | The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Methyclothiazide. |
| Bromocriptine | The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Methyclothiazide. |
| Gliquidone | The therapeutic efficacy of Gliquidone can be decreased when used in combination with Methyclothiazide. |
| Mitiglinide | The therapeutic efficacy of Mitiglinide can be decreased when used in combination with Methyclothiazide. |
| Sitagliptin | The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Methyclothiazide. |
| Sunitinib | The therapeutic efficacy of Sunitinib can be decreased when used in combination with Methyclothiazide. |
| Exenatide | The therapeutic efficacy of Exenatide can be decreased when used in combination with Methyclothiazide. |
| Mecasermin | The therapeutic efficacy of Mecasermin can be decreased when used in combination with Methyclothiazide. |
| Pramlintide | The therapeutic efficacy of Pramlintide can be decreased when used in combination with Methyclothiazide. |
| Glisoxepide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Methyclothiazide. |
| Insulin aspart | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin aspart. |
| Insulin detemir | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin detemir. |
| Insulin glulisine | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin glulisine. |
| Glymidine | The therapeutic efficacy of Glymidine can be decreased when used in combination with Methyclothiazide. |
| AICA ribonucleotide | The therapeutic efficacy of AICA ribonucleotide can be decreased when used in combination with Methyclothiazide. |
| Buformin | The therapeutic efficacy of Buformin can be decreased when used in combination with Methyclothiazide. |
| Vildagliptin | The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Methyclothiazide. |
| Voglibose | The therapeutic efficacy of Voglibose can be decreased when used in combination with Methyclothiazide. |
| NN344 | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with NN344. |
| AMG-222 | The therapeutic efficacy of AMG-222 can be decreased when used in combination with Methyclothiazide. |
| Bisegliptin | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Methyclothiazide. |
| Alogliptin | The therapeutic efficacy of Alogliptin can be decreased when used in combination with Methyclothiazide. |
| Dapagliflozin | The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Methyclothiazide. |
| Saxagliptin | The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Methyclothiazide. |
| Liraglutide | The therapeutic efficacy of Liraglutide can be decreased when used in combination with Methyclothiazide. |
| Gosogliptin | The therapeutic efficacy of Gosogliptin can be decreased when used in combination with Methyclothiazide. |
| Linagliptin | The therapeutic efficacy of Linagliptin can be decreased when used in combination with Methyclothiazide. |
| Canagliflozin | The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Methyclothiazide. |
| Glibornuride | The therapeutic efficacy of Glibornuride can be decreased when used in combination with Methyclothiazide. |
| Benfluorex | The therapeutic efficacy of Benfluorex can be decreased when used in combination with Methyclothiazide. |
| Albiglutide | The therapeutic efficacy of Albiglutide can be decreased when used in combination with Methyclothiazide. |
| Dulaglutide | The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Methyclothiazide. |
| Lobeglitazone | The therapeutic efficacy of Lobeglitazone can be decreased when used in combination with Methyclothiazide. |
| Netoglitazone | The therapeutic efficacy of Netoglitazone can be decreased when used in combination with Methyclothiazide. |
| Rivoglitazone | The therapeutic efficacy of Rivoglitazone can be decreased when used in combination with Methyclothiazide. |
| Ciglitazone | The therapeutic efficacy of Ciglitazone can be decreased when used in combination with Methyclothiazide. |
| Lixisenatide | The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Methyclothiazide. |
| Insulin beef | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin beef. |
| Insulin degludec | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin degludec. |
| Insulin peglispro | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin peglispro. |
| Insulin tregopil | The risk or severity of hypoglycemia can be increased when Methyclothiazide is combined with Insulin tregopil. |
| Ipragliflozin | The therapeutic efficacy of Ipragliflozin can be decreased when used in combination with Methyclothiazide. |
| Dutogliptin | The therapeutic efficacy of Dutogliptin can be decreased when used in combination with Methyclothiazide. |
| Allicin | The therapeutic efficacy of Allicin can be decreased when used in combination with Methyclothiazide. |
| Tofogliflozin | The therapeutic efficacy of Tofogliflozin can be decreased when used in combination with Methyclothiazide. |
| Ertugliflozin | The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Methyclothiazide. |
| 2,4-thiazolidinedione | The therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Methyclothiazide. |
| Teneligliptin | The therapeutic efficacy of Teneligliptin can be decreased when used in combination with Methyclothiazide. |