Peringatan Keamanan

Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.

Cefotiam

DB00229

small molecule approved investigational

Deskripsi

One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

Struktur Molekul 2D

Berat 525.628
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 1 hour.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed following intramuscular injection. Bioavailability is 60% following intramuscular injection.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

885 Data
Probenecid The serum concentration of Cefotiam can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefotiam.
Tenofovir disoproxil Cefotiam may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefotiam may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefotiam may increase the nephrotoxic activities of Tenofovir.
Aspartame The excretion of Cefotiam can be decreased when combined with Aspartame.
Pravastatin The excretion of Cefotiam can be decreased when combined with Pravastatin.
Succinic acid The excretion of Succinic acid can be decreased when combined with Cefotiam.
Citrulline The excretion of Citrulline can be decreased when combined with Cefotiam.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Cefotiam.
Zidovudine The excretion of Zidovudine can be decreased when combined with Cefotiam.
Cefdinir The excretion of Cefdinir can be decreased when combined with Cefotiam.
Leucovorin The excretion of Leucovorin can be decreased when combined with Cefotiam.
Fluorescein The excretion of Fluorescein can be decreased when combined with Cefotiam.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Cefotiam.
Quinapril The excretion of Quinapril can be decreased when combined with Cefotiam.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Cefotiam.
Famotidine The excretion of Famotidine can be decreased when combined with Cefotiam.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Cefotiam.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Cefotiam.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Cefotiam.
Captopril The excretion of Captopril can be decreased when combined with Cefotiam.
Tazobactam The excretion of Tazobactam can be decreased when combined with Cefotiam.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cefotiam.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Cefotiam.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Cefotiam.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Cefotiam.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Cefotiam.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Cefotiam.
Avibactam The excretion of Avibactam can be decreased when combined with Cefotiam.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Cefotiam.
Silibinin The excretion of Silibinin can be decreased when combined with Cefotiam.
Relebactam The excretion of Relebactam can be decreased when combined with Cefotiam.
Lansoprazole The excretion of Cefotiam can be decreased when combined with Lansoprazole.
Guanidine The excretion of Cefotiam can be decreased when combined with Guanidine.
Enalapril The excretion of Cefotiam can be decreased when combined with Enalapril.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Cefotiam.
Esomeprazole The excretion of Cefotiam can be decreased when combined with Esomeprazole.
Minocycline The excretion of Cefotiam can be decreased when combined with Minocycline.
Novobiocin The excretion of Cefotiam can be decreased when combined with Novobiocin.
Melatonin The excretion of Cefotiam can be decreased when combined with Melatonin.
Ouabain The excretion of Cefotiam can be decreased when combined with Ouabain.
Liotrix The excretion of Cefotiam can be decreased when combined with Liotrix.
Cilastatin The excretion of Cefotiam can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Cefotiam can be decreased when combined with trans-2-hydroxycinnamic acid.
Benzoic acid The excretion of Cefotiam can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Cefotiam can be decreased when combined with Caprylic acid.
Ataluren The excretion of Cefotiam can be decreased when combined with Ataluren.
Teriflunomide The excretion of Cefotiam can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Cefotiam can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Cefotiam can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Cefotiam can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Cefotiam can be decreased when combined with Cabotegravir.
Pradigastat The excretion of Cefotiam can be decreased when combined with Pradigastat.
Enasidenib The excretion of Cefotiam can be decreased when combined with Enasidenib.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Cefotiam.
Pantoprazole The excretion of Cefotiam can be decreased when combined with Pantoprazole.
Liothyronine The excretion of Cefotiam can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Conjugated estrogens can be decreased when combined with Cefotiam.
Piperacillin The excretion of Piperacillin can be decreased when combined with Cefotiam.
Trifluridine The excretion of Trifluridine can be decreased when combined with Cefotiam.
Allopurinol The excretion of Allopurinol can be decreased when combined with Cefotiam.
Cimetidine The excretion of Cimetidine can be decreased when combined with Cefotiam.
Piroxicam The excretion of Cefotiam can be decreased when combined with Piroxicam.
Methotrexate The excretion of Methotrexate can be decreased when combined with Cefotiam.
Cephalexin The excretion of Cephalexin can be decreased when combined with Cefotiam.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Cefotiam.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Cefotiam.
Tetracycline The excretion of Tetracycline can be decreased when combined with Cefotiam.
Estradiol The excretion of Estradiol can be decreased when combined with Cefotiam.
Acyclovir The excretion of Acyclovir can be decreased when combined with Cefotiam.
Cefaclor The excretion of Cefaclor can be decreased when combined with Cefotiam.
Ranitidine The excretion of Ranitidine can be decreased when combined with Cefotiam.
Bumetanide The excretion of Bumetanide can be decreased when combined with Cefotiam.
Ganciclovir The excretion of Cefotiam can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Cefotiam can be decreased when combined with Ketoprofen.
Ibuprofen The excretion of Cefotiam can be decreased when combined with Ibuprofen.
Cefadroxil The excretion of Cefotiam can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Cefotiam can be decreased when combined with Ceftriaxone.
Gemfibrozil The excretion of Cefotiam can be decreased when combined with Gemfibrozil.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Cefotiam.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Cefotiam.
Topiroxostat The excretion of Cefotiam can be decreased when combined with Topiroxostat.
Doripenem The excretion of Doripenem can be decreased when combined with Cefotiam.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Cefotiam.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Cefotiam.
Apalutamide The excretion of Cefotiam can be decreased when combined with Apalutamide.
Dronedarone The excretion of Cefotiam can be decreased when combined with Dronedarone.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Cefotiam.
Favipiravir The excretion of Cefotiam can be decreased when combined with Favipiravir.
Polythiazide The excretion of Polythiazide can be decreased when combined with Cefotiam.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Cefotiam.
Tafamidis The excretion of Cefotiam can be decreased when combined with Tafamidis.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Cefotiam.
Linezolid The excretion of Cefotiam can be decreased when combined with Linezolid.
Acamprosate The excretion of Acamprosate can be decreased when combined with Cefotiam.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefotiam.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefotiam.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefotiam.

Target Protein

Peptidoglycan synthase FtsI ftsI
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12642969
    Muller R, Bottger C, Wichmann G: Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients. Arzneimittelforschung. 2003;53(2):126-32.
  • PMID: 11245321
    Kolben M, Mandoki E, Ulm K, Freitag K: Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section. Eur J Clin Microbiol Infect Dis. 2001 Jan;20(1):40-2.
  • PMID: 8829507
    Shimizu S, Chen KR, Miyakawa S: Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses. Dermatology. 1996;192(2):174-6.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Ceradon
  • Pansporin — Takeda Pharmaceutical

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul