GBCAs cross the human placenta and result in fetal exposure and gadolinium retention. The human data on the association between GBCAs and adverse fetal outcomes are limited and inconclusive. In animal reproduction studies, no adverse fetal effects were observed with the administration of gadodiamide to pregnant rats during organogenesis at doses 1.3 times the maximum human dose based on body surface area. Because of the potential risks of gadolinium to the fetus, use gadodiamide only if imaging is essential during pregnancy and cannot be delayed.L49881
Clinical consequences of overdose with gadodiamide have not been reported. The minimum lethal dose of intravenously administered gadodiamide in rats and mice is greater than 20 mmol/kg (200 times the recommended human dose of 0.1 mmol/kg; 67 times the cumulative 0.3 mmol/kg dose). Gadodiamide is dialyzable.L49881
Long-term animal studies have not been performed to evaluate the carcinogenic potential of gadodiamide. The results of the following genotoxicity assays were negative: in vitro bacterial reverse mutation assay, in vitro Chinese Hamster Ovary (CHO)/Hypoxanthine Guanine Phosphoribosyl Transferase (HGPT) forward mutation assay, in vitro CHO chromosome aberration assay, and the in vivo mouse micronucleus assay at intravenous doses of 27 mmol/kg (approximately 7 times the maximum human dose based on a body surface area comparison). Impairment of male or female fertility was not observed in rats after intravenous administration three times per week at the maximum dose tested of 1.0 mmol/kg (approximately 0.5 times the maximum human dose based on a body surface area comparison).L49881
Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.A263086,A263091 GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents.A263096 Approved by the FDA in 1993, gadodiamide is the first non-ionic GBCA to be used.A263101 However, since linear, non-ionic GBCA is less stable than macrocyclic or ionic GBCA, gadodiamide can potentially lead to more gadolinium retention in the brain and thus more likely to cause side effects.A263106
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Cyclosporine | Cyclosporine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Methotrexate | Methotrexate may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cephalexin | Cephalexin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Tacrolimus | Tacrolimus may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Atazanavir | Atazanavir may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Magnesium salicylate | Magnesium salicylate may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Choline magnesium trisalicylate | Choline magnesium trisalicylate may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefacetrile | Cefacetrile may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Aminophenazone | Aminophenazone may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Antipyrine | Antipyrine may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Lopinavir | Lopinavir may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Etoricoxib | Etoricoxib may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Hydrolyzed Cephalothin | Hydrolyzed Cephalothin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cephalothin Group | Cephalothin Group may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Latamoxef | Latamoxef may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Nimesulide | Nimesulide may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Benoxaprofen | Benoxaprofen may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Metamizole | Metamizole may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Zomepirac | Zomepirac may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ceftobiprole | Ceftobiprole may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Cimicoxib | Cimicoxib may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Ceftaroline fosamil | Ceftaroline fosamil may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Lornoxicam | Lornoxicam may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |
| Aceclofenac | Aceclofenac may decrease the excretion rate of Gadodiamide which could result in a higher serum level. |