Peringatan Keamanan

Symptoms of overdose include myocardial infarction and angina pectoris.

Indinavir

DB00224

small molecule approved

Deskripsi

A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. PubChem

Struktur Molekul 2D

Berat 613.7895
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.8 (± 0.4) hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed

Metabolisme

Hepatic. Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 (CYP3A4) is the major enzyme responsible for formation of the oxidative metabolites.

Rute Eliminasi

Less than 20% of indinavir is excreted unchanged in the urine.

Interaksi Makanan

4 Data
  • 1. Avoid excessive or chronic alcohol consumption.
  • 2. Avoid grapefruit products.
  • 3. Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
  • 4. Take with a full glass of water.

Interaksi Obat

1114 Data
Reserpine Reserpine may decrease the excretion rate of Indinavir which could result in a higher serum level.
Ursodeoxycholic acid Ursodeoxycholic acid may decrease the excretion rate of Indinavir which could result in a higher serum level.
Cholic Acid Cholic Acid may decrease the excretion rate of Indinavir which could result in a higher serum level.
Valinomycin Valinomycin may decrease the excretion rate of Indinavir which could result in a higher serum level.
Olmesartan Olmesartan may decrease the excretion rate of Indinavir which could result in a higher serum level.
Lenvatinib Lenvatinib may decrease the excretion rate of Indinavir which could result in a higher serum level.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Indinavir.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Indinavir.
Pantoprazole Pantoprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Omeprazole Omeprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lansoprazole Lansoprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Esomeprazole Esomeprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rabeprazole Rabeprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dexlansoprazole Dexlansoprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dexrabeprazole Dexrabeprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ilaprazole Ilaprazole can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Vonoprazan The metabolism of Vonoprazan can be decreased when combined with Indinavir.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Indinavir.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Indinavir.
Clarithromycin The serum concentration of Clarithromycin can be increased when it is combined with Indinavir.
Cyclophosphamide The serum concentration of the active metabolites of Cyclophosphamide can be increased when Cyclophosphamide is used in combination with Indinavir.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Indinavir.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Indinavir.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Indinavir.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Indinavir.
Atovaquone Atovaquone can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bosentan The serum concentration of Bosentan can be increased when it is combined with Indinavir.
Didanosine Didanosine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Efavirenz The serum concentration of Indinavir can be decreased when it is combined with Efavirenz.
Irinotecan The serum concentration of the active metabolites of Irinotecan can be decreased when Irinotecan is used in combination with Indinavir.
Itraconazole The metabolism of Indinavir can be decreased when combined with Itraconazole.
Nevirapine The serum concentration of Indinavir can be decreased when it is combined with Nevirapine.
Rifabutin The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Indinavir.
Venlafaxine The serum concentration of Indinavir can be decreased when it is combined with Venlafaxine.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Indinavir.
Olanzapine Olanzapine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cimetidine Cimetidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nizatidine Nizatidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ranitidine Ranitidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famotidine Famotidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methantheline Methantheline can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Promethazine Promethazine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Doxepin Doxepin can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Asenapine Asenapine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metiamide Metiamide can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Roxatidine acetate Roxatidine acetate can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lafutidine Lafutidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lavoltidine Lavoltidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Niperotidine Niperotidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Epinastine Epinastine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Indinavir.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Indinavir.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Indinavir.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Indinavir.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Indinavir.
Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Indinavir.
Garlic Garlic can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Insulin human The therapeutic efficacy of Insulin human can be decreased when used in combination with Indinavir.
Insulin lispro The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Indinavir.
Insulin glargine The therapeutic efficacy of Insulin glargine can be decreased when used in combination with Indinavir.
Insulin pork The therapeutic efficacy of Insulin pork can be decreased when used in combination with Indinavir.
Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Indinavir.
Sulfisoxazole The therapeutic efficacy of Sulfisoxazole can be decreased when used in combination with Indinavir.
Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Indinavir.
Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Indinavir.
Miglitol The therapeutic efficacy of Miglitol can be decreased when used in combination with Indinavir.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Indinavir.
Pentamidine The therapeutic efficacy of Pentamidine can be decreased when used in combination with Indinavir.
Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Indinavir.
Phenformin The therapeutic efficacy of Phenformin can be decreased when used in combination with Indinavir.
Gliclazide The therapeutic efficacy of Gliclazide can be decreased when used in combination with Indinavir.
Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Indinavir.
Gliquidone The therapeutic efficacy of Gliquidone can be decreased when used in combination with Indinavir.
Mitiglinide The therapeutic efficacy of Mitiglinide can be decreased when used in combination with Indinavir.
Exenatide The therapeutic efficacy of Exenatide can be decreased when used in combination with Indinavir.
Mecasermin The therapeutic efficacy of Mecasermin can be decreased when used in combination with Indinavir.
Pramlintide The therapeutic efficacy of Pramlintide can be decreased when used in combination with Indinavir.
Glisoxepide The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Indinavir.
Insulin aspart The therapeutic efficacy of Insulin aspart can be decreased when used in combination with Indinavir.
Insulin detemir The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Indinavir.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Indinavir.
Glymidine The therapeutic efficacy of Glymidine can be decreased when used in combination with Indinavir.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be decreased when used in combination with Indinavir.
Buformin The therapeutic efficacy of Buformin can be decreased when used in combination with Indinavir.
Vildagliptin The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Indinavir.
Voglibose The therapeutic efficacy of Voglibose can be decreased when used in combination with Indinavir.
NN344 The therapeutic efficacy of NN344 can be decreased when used in combination with Indinavir.
AMG-222 The therapeutic efficacy of AMG-222 can be decreased when used in combination with Indinavir.
Bisegliptin The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Indinavir.
Liraglutide The therapeutic efficacy of Liraglutide can be decreased when used in combination with Indinavir.
Gosogliptin The therapeutic efficacy of Gosogliptin can be decreased when used in combination with Indinavir.
Glibornuride The therapeutic efficacy of Glibornuride can be decreased when used in combination with Indinavir.
Benfluorex The therapeutic efficacy of Benfluorex can be decreased when used in combination with Indinavir.
Empagliflozin The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Indinavir.
Albiglutide The therapeutic efficacy of Albiglutide can be decreased when used in combination with Indinavir.
Dulaglutide The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Indinavir.
Lixisenatide The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Indinavir.
Insulin beef The therapeutic efficacy of Insulin beef can be decreased when used in combination with Indinavir.
Insulin degludec The therapeutic efficacy of Insulin degludec can be decreased when used in combination with Indinavir.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be decreased when used in combination with Indinavir.

Target Protein

Gag-Pol polyprotein gag-pol
Pol polyprotein pol

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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