Bethanidine

DB00217

small molecule approved

Deskripsi

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

Struktur Molekul 2D

Berat 177.2462
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 9 hours (range 7 to 11 hours)
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed rapidly in the gastrointestinal tract following oral administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

758 Data
Alfuzosin Alfuzosin may increase the hypotensive activities of Bethanidine.
Amifostine Bethanidine may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Bethanidine.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Bethanidine.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Bethanidine.
Obinutuzumab Bethanidine may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Bethanidine.
Rituximab Bethanidine may increase the hypotensive activities of Rituximab.
Angiotensin 1-7 Bethanidine may decrease the antihypertensive activities of Angiotensin 1-7.
Yohimbine Yohimbine may decrease the antihypertensive activities of Bethanidine.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Bethanidine.
Siponimod Siponimod may decrease the antihypertensive activities of Bethanidine.
Felodipine Bethanidine may decrease the antihypertensive activities of Felodipine.
Valsartan Bethanidine may decrease the antihypertensive activities of Valsartan.
Ramipril Bethanidine may decrease the antihypertensive activities of Ramipril.
Reserpine Bethanidine may decrease the antihypertensive activities of Reserpine.
Torasemide Bethanidine may decrease the antihypertensive activities of Torasemide.
Isradipine Bethanidine may decrease the antihypertensive activities of Isradipine.
Olmesartan Bethanidine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Bethanidine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Bethanidine may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Bethanidine may decrease the antihypertensive activities of Diltiazem.
Minoxidil Bethanidine may decrease the antihypertensive activities of Minoxidil.
Amlodipine Bethanidine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Bethanidine may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Bethanidine may decrease the antihypertensive activities of Nisoldipine.
Fosinopril Bethanidine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Bethanidine may decrease the antihypertensive activities of Trandolapril.
Metolazone Bethanidine may decrease the antihypertensive activities of Metolazone.
Lercanidipine Bethanidine may decrease the antihypertensive activities of Lercanidipine.
Benazepril Bethanidine may decrease the antihypertensive activities of Benazepril.
Enalapril Bethanidine may decrease the antihypertensive activities of Enalapril.
Dexmedetomidine Dexmedetomidine may decrease the antihypertensive activities of Bethanidine.
Mecamylamine Bethanidine may decrease the antihypertensive activities of Mecamylamine.
Losartan Bethanidine may decrease the antihypertensive activities of Losartan.
Moexipril Bethanidine may decrease the antihypertensive activities of Moexipril.
Furosemide Bethanidine may decrease the antihypertensive activities of Furosemide.
Eplerenone Bethanidine may decrease the antihypertensive activities of Eplerenone.
Sufentanil Sufentanil may decrease the antihypertensive activities of Bethanidine.
Lisinopril Bethanidine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Bethanidine may decrease the antihypertensive activities of Nitroglycerin.
Isoflurane Isoflurane may decrease the antihypertensive activities of Bethanidine.
Perindopril Bethanidine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Bethanidine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Bethanidine may decrease the antihypertensive activities of Fenoldopam.
Propofol Propofol may decrease the antihypertensive activities of Bethanidine.
Eprosartan Bethanidine may decrease the antihypertensive activities of Eprosartan.
Quinapril Bethanidine may decrease the antihypertensive activities of Quinapril.
Remifentanil Remifentanil may decrease the antihypertensive activities of Bethanidine.
Telmisartan Bethanidine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Bethanidine may decrease the antihypertensive activities of Methyldopa.
Guanfacine Bethanidine may decrease the antihypertensive activities of Guanfacine.
Irbesartan Bethanidine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Bethanidine may decrease the antihypertensive activities of Nitrendipine.
Bretylium Bethanidine may decrease the antihypertensive activities of Bretylium.
Halothane Halothane may decrease the antihypertensive activities of Bethanidine.
Desflurane Desflurane may decrease the antihypertensive activities of Bethanidine.
Captopril Bethanidine may decrease the antihypertensive activities of Captopril.
Sevoflurane Sevoflurane may decrease the antihypertensive activities of Bethanidine.
Bepridil Bethanidine may decrease the antihypertensive activities of Bepridil.
Hydralazine Bethanidine may decrease the antihypertensive activities of Hydralazine.
Cilazapril Bethanidine may decrease the antihypertensive activities of Cilazapril.
Lofexidine Bethanidine may decrease the antihypertensive activities of Lofexidine.
Rotigotine Rotigotine may decrease the antihypertensive activities of Bethanidine.
Nilvadipine Bethanidine may decrease the antihypertensive activities of Nilvadipine.
Azilsartan medoxomil Bethanidine may decrease the antihypertensive activities of Azilsartan medoxomil.
Riociguat Bethanidine may decrease the antihypertensive activities of Riociguat.
Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Bethanidine.
Aliskiren Bethanidine may decrease the antihypertensive activities of Aliskiren.
Efonidipine Bethanidine may decrease the antihypertensive activities of Efonidipine.
Lacidipine Bethanidine may decrease the antihypertensive activities of Lacidipine.
Moxonidine Bethanidine may decrease the antihypertensive activities of Moxonidine.
Enalaprilat Bethanidine may decrease the antihypertensive activities of Enalaprilat.
Imidapril Bethanidine may decrease the antihypertensive activities of Imidapril.
Acetylsalicylic acid Acetylsalicylic acid may decrease the antihypertensive activities of Bethanidine.
Selpercatinib Selpercatinib may decrease the antihypertensive activities of Bethanidine.
Naxitamab Naxitamab may decrease the antihypertensive activities of Bethanidine.
Levamlodipine Bethanidine may decrease the antihypertensive activities of Levamlodipine.
Amphetamine Amphetamine may decrease the antihypertensive activities of Bethanidine.
Desmopressin Desmopressin may decrease the antihypertensive activities of Bethanidine.
Cyclosporine Cyclosporine may decrease the antihypertensive activities of Bethanidine.
Phentermine Phentermine may decrease the antihypertensive activities of Bethanidine.
Midodrine Midodrine may decrease the antihypertensive activities of Bethanidine.
Eletriptan Eletriptan may decrease the antihypertensive activities of Bethanidine.
Isoetharine Isoetharine may decrease the antihypertensive activities of Bethanidine.
Atomoxetine Atomoxetine may decrease the antihypertensive activities of Bethanidine.
Etomidate Etomidate may decrease the antihypertensive activities of Bethanidine.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Bethanidine.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Bethanidine.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Bethanidine.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Bethanidine.
Buspirone Buspirone may decrease the antihypertensive activities of Bethanidine.
Doxapram Doxapram may decrease the antihypertensive activities of Bethanidine.
Atropine Atropine may decrease the antihypertensive activities of Bethanidine.
Metaraminol Metaraminol may decrease the antihypertensive activities of Bethanidine.
Epinephrine Epinephrine may decrease the antihypertensive activities of Bethanidine.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Bethanidine.
Methoxamine Methoxamine may decrease the antihypertensive activities of Bethanidine.
Alfentanil Alfentanil may decrease the antihypertensive activities of Bethanidine.
Fentanyl Fentanyl may decrease the antihypertensive activities of Bethanidine.

Target Protein

Beta-1 adrenergic receptor ADRB1
ATP-sensitive inward rectifier potassium channel 1 KCNJ1
Alpha-2 adrenergic receptors ADRA2A
Beta adrenergic receptor ADRB1

Referensi & Sumber

Synthesis reference: Khashayar Karimian, Keshava Murthy, Darren Hall, "Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof." U.S. Patent US5686612, issued November, 1990.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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