Peringatan Keamanan

Based on the pharmacology of the 5-HT1B/1D agonists, hypertension or other more serious cardiovascular symptoms could occur on overdose.

Eletriptan

DB00216

small molecule approved investigational

Deskripsi

Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.

Struktur Molekul 2D

Berat 382.519
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The terminal elimination half-life of eletriptan is approximately 4 hours.
Volume Distribusi * 138 L
Klirens (Clearance) * Renal cl=3.9 L/h

Absorpsi

Well absorbed after oral administration with a mean absolute bioavailability of approximately 50%.

Metabolisme

In vitro studies indicate that eletriptan is primarily metabolized by cytochrome P-450 enzyme CYP3A4. The N-demethylated metabolite of eletriptan is the only known active metabolite.

Rute Eliminasi

Data eliminasi belum tersedia.

Farmakogenomik

1 Varian
GNB3 (rs5443)

Patients with this genotype have an increased likelihood of responding to elitriptan when treating (condition: cluster headache).

Interaksi Makanan

1 Data
  • 1. Take with or without food. High-fat meals increase exposure, but not to a clinically relevant extent.

Interaksi Obat

1427 Data
Ramipril Eletriptan may decrease the antihypertensive activities of Ramipril.
Remikiren Eletriptan may decrease the antihypertensive activities of Remikiren.
Guanadrel Eletriptan may decrease the antihypertensive activities of Guanadrel.
Olmesartan Eletriptan may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Eletriptan may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Eletriptan may decrease the antihypertensive activities of Nitroprusside.
Atenolol Eletriptan may decrease the antihypertensive activities of Atenolol.
Minoxidil Eletriptan may decrease the antihypertensive activities of Minoxidil.
Bendroflumethiazide Eletriptan may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Eletriptan may decrease the antihypertensive activities of Fosinopril.
Trandolapril Eletriptan may decrease the antihypertensive activities of Trandolapril.
Metolazone Eletriptan may decrease the antihypertensive activities of Metolazone.
Benazepril Eletriptan may decrease the antihypertensive activities of Benazepril.
Cyclothiazide Eletriptan may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Eletriptan may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Eletriptan may decrease the antihypertensive activities of Mecamylamine.
Moexipril Eletriptan may decrease the antihypertensive activities of Moexipril.
Lisinopril Eletriptan may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Eletriptan may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Eletriptan may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Eletriptan may decrease the antihypertensive activities of Cryptenamine.
Perindopril Eletriptan may decrease the antihypertensive activities of Perindopril.
Fenoldopam Eletriptan may decrease the antihypertensive activities of Fenoldopam.
Eprosartan Eletriptan may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Eletriptan may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Eletriptan may decrease the antihypertensive activities of Quinapril.
Methyldopa Eletriptan may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Eletriptan may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Eletriptan may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Eletriptan may decrease the antihypertensive activities of Deserpidine.
Pentolinium Eletriptan may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Eletriptan may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Eletriptan may decrease the antihypertensive activities of Diazoxide.
Bretylium Eletriptan may decrease the antihypertensive activities of Bretylium.
Epoprostenol Eletriptan may decrease the antihypertensive activities of Epoprostenol.
Polythiazide Eletriptan may decrease the antihypertensive activities of Polythiazide.
Saprisartan Eletriptan may decrease the antihypertensive activities of Saprisartan.
Spirapril Eletriptan may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Eletriptan may decrease the antihypertensive activities of Dexpropranolol.
Diethylnorspermine Eletriptan may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Eletriptan may decrease the antihypertensive activities of Temocapril.
Trimazosin Eletriptan may decrease the antihypertensive activities of Trimazosin.
Nicorandil Eletriptan may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Eletriptan may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Eletriptan may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Eletriptan may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Eletriptan may decrease the antihypertensive activities of Imidapril.
BQ-123 Eletriptan may decrease the antihypertensive activities of BQ-123.
Cicletanine Eletriptan may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Eletriptan may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Eletriptan may decrease the antihypertensive activities of Zofenopril.
Guanoxan Eletriptan may decrease the antihypertensive activities of Guanoxan.
Delapril Eletriptan may decrease the antihypertensive activities of Delapril.
Vincamine Eletriptan may decrease the antihypertensive activities of Vincamine.
Linsidomine Eletriptan may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Eletriptan may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Eletriptan may decrease the antihypertensive activities of Tolonidine.
Endralazine Eletriptan may decrease the antihypertensive activities of Endralazine.
Cadralazine Eletriptan may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Eletriptan may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Eletriptan may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Eletriptan may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Eletriptan may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Eletriptan may decrease the antihypertensive activities of Guanoclor.
Muzolimine Eletriptan may decrease the antihypertensive activities of Muzolimine.
Xipamide Eletriptan may decrease the antihypertensive activities of Xipamide.
Tocopherylquinone Eletriptan may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Eletriptan may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Eletriptan may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Eletriptan may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Eletriptan may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Eletriptan may decrease the antihypertensive activities of Quinaprilat.
Furosemide Eletriptan may decrease the antihypertensive activities of Furosemide.
Eplerenone Eletriptan may decrease the antihypertensive activities of Eplerenone.
Indapamide Eletriptan may decrease the antihypertensive activities of Indapamide.
Tadalafil Eletriptan may decrease the antihypertensive activities of Tadalafil.
Guanethidine Eletriptan may decrease the antihypertensive activities of Guanethidine.
Nebivolol Eletriptan may decrease the antihypertensive activities of Nebivolol.
Pinacidil Eletriptan may decrease the antihypertensive activities of Pinacidil.
Riociguat Eletriptan may decrease the antihypertensive activities of Riociguat.
Macitentan Eletriptan may decrease the antihypertensive activities of Macitentan.
Aliskiren Eletriptan may decrease the antihypertensive activities of Aliskiren.
Lacidipine Eletriptan may decrease the antihypertensive activities of Lacidipine.
Naftopidil Eletriptan may decrease the antihypertensive activities of Naftopidil.
Nimodipine Eletriptan may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Eletriptan may decrease the antihypertensive activities of Nisoldipine.
Prazosin Eletriptan may decrease the antihypertensive activities of Prazosin.
Enalapril Eletriptan may decrease the antihypertensive activities of Enalapril.
Bisoprolol Eletriptan may decrease the antihypertensive activities of Bisoprolol.
Telmisartan Eletriptan may decrease the antihypertensive activities of Telmisartan.
Nitrendipine Eletriptan may decrease the antihypertensive activities of Nitrendipine.
Terazosin Eletriptan may decrease the antihypertensive activities of Terazosin.
Captopril Eletriptan may decrease the antihypertensive activities of Captopril.
Cilazapril Eletriptan may decrease the antihypertensive activities of Cilazapril.
Ambrisentan Eletriptan may decrease the antihypertensive activities of Ambrisentan.
Niguldipine Eletriptan may decrease the antihypertensive activities of Niguldipine.
Selexipag Eletriptan may decrease the antihypertensive activities of Selexipag.
Dexniguldipine Eletriptan may decrease the antihypertensive activities of Dexniguldipine.
Doxazosin Eletriptan may decrease the antihypertensive activities of Doxazosin.
Losartan Eletriptan may decrease the antihypertensive activities of Losartan.

Target Protein

5-hydroxytryptamine receptor 1D HTR1D
5-hydroxytryptamine receptor 1B HTR1B
5-hydroxytryptamine receptor 1F HTR1F
5-hydroxytryptamine receptor 1A HTR1A

Referensi & Sumber

Synthesis reference: Ronald Ogilvie, "Process for the preparation of eletriptan." U.S. Patent US20050059828, issued March 17, 2005.

Contoh Produk & Brand

Produk: 50 • International brands: 0
Produk
  • Apo-eletriptan
    Tablet • 20 mg • Oral • Canada • Generic • Approved
  • Apo-eletriptan
    Tablet • 40 mg • Oral • Canada • Generic • Approved
  • Apo-eletriptan Tablets
    Tablet • 20 mg • Oral • Canada • Generic • Approved
  • Apo-eletriptan Tablets
    Tablet • 40 mg • Oral • Canada • Generic • Approved
  • Auro-eletriptan
    Tablet • 20 mg • Oral • Canada • Generic • Approved
  • Auro-eletriptan
    Tablet • 40 mg • Oral • Canada • Generic • Approved
  • Eletriptan
    Tablet, film coated • 20 mg/1 • Oral • US • Generic • Approved
  • Eletriptan
    Tablet, film coated • 40 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 50 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul