Peringatan Keamanan

Symptoms of overdose could include hypertension, piloerection (goosebumps), a sensation of coldness and urinary retention. The single doses that would be associated with symptoms of overdosage or would be potentially life- threatening are unknown. The oral LD50 is approximately 30 to 50 mg/kg in rats, 675 mg/kg in mice, and 125 to 160 mg/kg in dogs. Desglymidodrine is dialyzable.

Midodrine

DB00211

small molecule approved

Deskripsi

An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.

Struktur Molekul 2D

Berat 254.2823
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The metabolites display a half-life of about 3 to 4 hours.
Volume Distribusi -
Klirens (Clearance) * Renal cl=385 mL/minute

Absorpsi

Rapidly absorbed following oral administration. The peak plasma concentrations of the prodrug, desglymidodrine, is reached about half an hour following drug administration. The metabolites reach their peak plasma concentrations at about 1 to 2 hours following drug administration. The absolute bioavailability of midodrine (measured as desglymidodrine) is 93% and is not affected by food. As desglymidodrine displays poor diffusibility across the blood-brain barrier, it is expected to have minimal effects on the central nervous system.

Metabolisme

Thorough metabolic studies have not been conducted, but it appears that deglycination of midodrine to desglymidodrine takes place in many tissues, and both compounds are metabolized in part by the liver.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

821 Data
Ceritinib Midodrine may increase the bradycardic activities of Ceritinib.
Ivabradine Midodrine may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Midodrine.
Valsartan Midodrine may decrease the antihypertensive activities of Valsartan.
Ramipril Midodrine may decrease the antihypertensive activities of Ramipril.
Reserpine Midodrine may decrease the antihypertensive activities of Reserpine.
Remikiren Midodrine may decrease the antihypertensive activities of Remikiren.
Torasemide Midodrine may decrease the antihypertensive activities of Torasemide.
Olmesartan Midodrine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Midodrine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Midodrine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Midodrine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Midodrine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Midodrine may decrease the antihypertensive activities of Amlodipine.
Fosinopril Midodrine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Midodrine may decrease the antihypertensive activities of Trandolapril.
Metolazone Midodrine may decrease the antihypertensive activities of Metolazone.
Benazepril Midodrine may decrease the antihypertensive activities of Benazepril.
Bosentan Midodrine may decrease the antihypertensive activities of Bosentan.
Enalapril Midodrine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Midodrine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Midodrine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Midodrine may decrease the antihypertensive activities of Mecamylamine.
Losartan Midodrine may decrease the antihypertensive activities of Losartan.
Moexipril Midodrine may decrease the antihypertensive activities of Moexipril.
Eplerenone Midodrine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Midodrine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Midodrine may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Midodrine may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide Midodrine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Midodrine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Midodrine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Midodrine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Midodrine may decrease the antihypertensive activities of Fenoldopam.
Indapamide Midodrine may decrease the antihypertensive activities of Indapamide.
Tadalafil Midodrine may decrease the antihypertensive activities of Tadalafil.
Eprosartan Midodrine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Midodrine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Midodrine may decrease the antihypertensive activities of Quinapril.
Telmisartan Midodrine may decrease the antihypertensive activities of Telmisartan.
Hydrochlorothiazide Midodrine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Midodrine may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Midodrine may decrease the antihypertensive activities of Irbesartan.
Deserpidine Midodrine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Midodrine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Midodrine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Midodrine may decrease the antihypertensive activities of Diazoxide.
Epoprostenol Midodrine may decrease the antihypertensive activities of Epoprostenol.
Hydralazine Midodrine may decrease the antihypertensive activities of Hydralazine.
Polythiazide Midodrine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Midodrine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Midodrine may decrease the antihypertensive activities of Saprisartan.
Spirapril Midodrine may decrease the antihypertensive activities of Spirapril.
Tienilic acid Midodrine may decrease the antihypertensive activities of Tienilic acid.
Sitaxentan Midodrine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Midodrine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Midodrine may decrease the antihypertensive activities of Diethylnorspermine.
Pinacidil Midodrine may decrease the antihypertensive activities of Pinacidil.
Temocapril Midodrine may decrease the antihypertensive activities of Temocapril.
Riociguat Midodrine may decrease the antihypertensive activities of Riociguat.
Macitentan Midodrine may decrease the antihypertensive activities of Macitentan.
Hexamethonium Midodrine may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Midodrine may decrease the antihypertensive activities of Aliskiren.
Nicorandil Midodrine may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Midodrine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Midodrine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Midodrine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Midodrine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Midodrine may decrease the antihypertensive activities of Imidapril.
BQ-123 Midodrine may decrease the antihypertensive activities of BQ-123.
Cicletanine Midodrine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Midodrine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Midodrine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Midodrine may decrease the antihypertensive activities of Guanoxan.
Delapril Midodrine may decrease the antihypertensive activities of Delapril.
Vincamine Midodrine may decrease the antihypertensive activities of Vincamine.
Linsidomine Midodrine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Midodrine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Midodrine may decrease the antihypertensive activities of Tolonidine.
Endralazine Midodrine may decrease the antihypertensive activities of Endralazine.
Cadralazine Midodrine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Midodrine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Midodrine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Midodrine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Midodrine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Midodrine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Midodrine may decrease the antihypertensive activities of Muzolimine.
Xipamide Midodrine may decrease the antihypertensive activities of Xipamide.
Candesartan Midodrine may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Midodrine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Midodrine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Midodrine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Midodrine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Midodrine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Midodrine may decrease the antihypertensive activities of Quinaprilat.
Felodipine Midodrine may decrease the antihypertensive activities of Felodipine.
Furosemide Midodrine may decrease the antihypertensive activities of Furosemide.
Diltiazem Midodrine may decrease the antihypertensive activities of Diltiazem.
Clonidine Midodrine may decrease the antihypertensive activities of Clonidine.
Captopril Midodrine may decrease the antihypertensive activities of Captopril.

Target Protein

Alpha-1A adrenergic receptor ADRA1A
Alpha-1B adrenergic receptor ADRA1B
Alpha-1D adrenergic receptor ADRA1D

Referensi & Sumber

Synthesis reference: Anup K. Ray, Hiren Patel, Mahendra R. Patel, "Synthesis of midodrine HCI from a novel intermediate 1-(2',5'-dimethoxyphenyl)-2-azidoethanone." U.S. Patent US6201153, issued July, 1965.
Artikel (PubMed)

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