Peringatan Keamanan

Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg

Reserpine

DB00206

small molecule approved investigational withdrawn

Deskripsi

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

The FDA withdrew its approval for the use of all oral dosage form drug products containing more than 1 mg of reserpine.L43942

Struktur Molekul 2D

Berat 608.6787
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Reserpine is extensively metabolized to inactive compounds. It is slowly excreted via the urine and feces.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

1861 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Reserpine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Reserpine is combined with Levodopa.
Risperidone Reserpine may increase the hypotensive activities of Risperidone.
Afatinib The serum concentration of Afatinib can be increased when it is combined with Reserpine.
Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Reserpine.
Brentuximab vedotin The serum concentration of Brentuximab vedotin can be increased when it is combined with Reserpine.
Glycochenodeoxycholic Acid Reserpine may decrease the excretion rate of Glycochenodeoxycholic Acid which could result in a higher serum level.
Pravastatin Reserpine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Nelfinavir Reserpine may decrease the excretion rate of Nelfinavir which could result in a higher serum level.
Glimepiride Reserpine may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Indinavir Reserpine may decrease the excretion rate of Indinavir which could result in a higher serum level.
Lovastatin The metabolism of Lovastatin can be increased when combined with Reserpine.
Diethylstilbestrol Reserpine may decrease the excretion rate of Diethylstilbestrol which could result in a higher serum level.
Isradipine Reserpine may decrease the excretion rate of Isradipine which could result in a higher serum level.
Flucloxacillin Reserpine may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Indomethacin Reserpine may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Terfenadine Reserpine may decrease the excretion rate of Terfenadine which could result in a higher serum level.
Rosiglitazone Reserpine may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Spironolactone Reserpine may increase the hypotensive activities of Spironolactone.
Cerivastatin Reserpine may decrease the excretion rate of Cerivastatin which could result in a higher serum level.
Loratadine Reserpine may decrease the excretion rate of Loratadine which could result in a higher serum level.
Ritonavir Reserpine may decrease the excretion rate of Ritonavir which could result in a higher serum level.
Atropine Reserpine may decrease the excretion rate of Atropine which could result in a higher serum level.
Diclofenac Reserpine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Nicardipine Reserpine may decrease the excretion rate of Nicardipine which could result in a higher serum level.
Efavirenz Reserpine may decrease the excretion rate of Efavirenz which could result in a higher serum level.
Simvastatin Reserpine may decrease the excretion rate of Simvastatin which could result in a higher serum level.
Losartan Reserpine may increase the hypotensive activities of Losartan.
Fluorescein Reserpine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Nitrofurantoin Reserpine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Naproxen Reserpine may decrease the excretion rate of Naproxen which could result in a higher serum level.
Disulfiram Reserpine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Cefaclor Reserpine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Mifepristone Reserpine may decrease the excretion rate of Mifepristone which could result in a higher serum level.
Tinidazole Reserpine may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Repaglinide Reserpine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Telmisartan Reserpine may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Ezetimibe Reserpine may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Dipyridamole Reserpine may decrease the excretion rate of Dipyridamole which could result in a higher serum level.
Sulfamethoxazole Reserpine may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
Fenofibrate Reserpine may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Nitrendipine Reserpine may decrease the excretion rate of Nitrendipine which could result in a higher serum level.
Glipizide Reserpine may decrease the excretion rate of Glipizide which could result in a higher serum level.
Atazanavir Reserpine may decrease the excretion rate of Atazanavir which could result in a higher serum level.
Atorvastatin Reserpine may decrease the excretion rate of Atorvastatin which could result in a higher serum level.
Rosuvastatin Reserpine may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Sulfinpyrazone Reserpine may decrease the excretion rate of Sulfinpyrazone which could result in a higher serum level.
Ofloxacin Reserpine may decrease the excretion rate of Ofloxacin which could result in a higher serum level.
Clarithromycin Reserpine may decrease the excretion rate of Clarithromycin which could result in a higher serum level.
Budesonide Reserpine may decrease the excretion rate of Budesonide which could result in a higher serum level.
Saquinavir Reserpine may decrease the excretion rate of Saquinavir which could result in a higher serum level.
Taurocholic acid Reserpine may decrease the excretion rate of Taurocholic acid which could result in a higher serum level.
Prasterone sulfate Reserpine may decrease the excretion rate of Prasterone sulfate which could result in a higher serum level.
Indocyanine green acid form Reserpine may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.
Benzbromarone Reserpine may decrease the excretion rate of Benzbromarone which could result in a higher serum level.
Pilsicainide Reserpine may decrease the excretion rate of Pilsicainide which could result in a higher serum level.
Glycyrrhizic acid Reserpine may decrease the excretion rate of Glycyrrhizic acid which could result in a higher serum level.
Imatinib Reserpine may decrease the excretion rate of Imatinib which could result in a higher serum level.
Belantamab mafodotin Reserpine may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Colchicine The serum concentration of Colchicine can be increased when it is combined with Reserpine.
Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Reserpine.
Ledipasvir The serum concentration of Ledipasvir can be increased when it is combined with Reserpine.
Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Reserpine.
Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Reserpine.
Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Reserpine.
Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Reserpine.
Silodosin The excretion of Silodosin can be decreased when combined with Reserpine.
Topotecan The serum concentration of Topotecan can be increased when it is combined with Reserpine.
Alfuzosin Alfuzosin may increase the hypotensive activities of Reserpine.
Amifostine Reserpine may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Reserpine.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Reserpine.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Reserpine.
Obinutuzumab Reserpine may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Reserpine.
Rituximab Reserpine may increase the hypotensive activities of Rituximab.
Midodrine Midodrine may decrease the antihypertensive activities of Reserpine.
Isoetharine Isoetharine may decrease the antihypertensive activities of Reserpine.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Reserpine.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Reserpine.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Reserpine.
Doxapram Doxapram may decrease the antihypertensive activities of Reserpine.
Metaraminol Metaraminol may decrease the antihypertensive activities of Reserpine.
Nicergoline Nicergoline may decrease the antihypertensive activities of Reserpine.
Methoxamine Methoxamine may decrease the antihypertensive activities of Reserpine.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Reserpine.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Reserpine.
Ritodrine Ritodrine may decrease the antihypertensive activities of Reserpine.
Bitolterol Bitolterol may decrease the antihypertensive activities of Reserpine.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Reserpine.
Arbutamine Arbutamine may decrease the antihypertensive activities of Reserpine.
Fenoterol Fenoterol may decrease the antihypertensive activities of Reserpine.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Reserpine.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Reserpine.
Ephedrine Ephedrine may decrease the antihypertensive activities of Reserpine.
Procaterol Procaterol may decrease the antihypertensive activities of Reserpine.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Reserpine.
Bambuterol Bambuterol may decrease the antihypertensive activities of Reserpine.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Reserpine.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Reserpine.

Target Protein

Synaptic vesicular amine transporter SLC18A2
Chromaffin granule amine transporter SLC18A1
Baculoviral IAP repeat-containing protein 5 BIRC5

Referensi & Sumber

Artikel (PubMed)
  • PMID: 490882
    Authors unspecified: Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group. JAMA. 1979 Dec 7;242(23):2562-71.
  • PMID: 4862069
    Authors unspecified: Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA. 1967 Dec 11;202(11):1028-34.
  • PMID: 2046107
    Authors unspecified: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA. 1991 Jun 26;265(24):3255-64.
  • PMID: 12748199
    Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003 May 21;289(19):2560-72. Epub 2003 May 14.
  • PMID: 3592424
    Moser M: "Cost containment" in the management of hypertension. Ann Intern Med. 1987 Jul;107(1):107-9.

Contoh Produk & Brand

Produk: 13 • International brands: 7
Produk
  • Diupres
    Tablet • - • Oral • US • Approved
  • Diupres
    Tablet • - • Oral • US • Approved
  • Hydropres 25 Tab
    Tablet • - • Oral • Canada • Approved
  • Hydropres 50 Tab
    Tablet • - • Oral • Canada • Approved
  • Novo-reserpine Tab 0.25mg
    Tablet • .25 mg • Oral • Canada • Generic • Approved
  • Renese-R
    Tablet • - • Oral • US • Approved
  • Reserpine
    Tablet • 0.1 mg/1 • Oral • US • Approved
  • Reserpine
    Tablet • 0.25 mg/1 • Oral • US • Approved
Menampilkan 8 dari 13 produk.
International Brands
  • Apoplon
  • Hiserpia
  • Novoreserpine
  • Reserfia
  • Serpalan
  • Serpanray
  • Serpasil

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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