One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Artemether | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Artemether. |
| Lumefantrine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Lumefantrine. |
| Tetrahydrofolic acid | The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with Tetrahydrofolic acid. |
| Folic acid | The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with Folic acid. |
| Leucovorin | The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with Leucovorin. |
| (6S)-5,6,7,8-tetrahydrofolic acid | The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with (6S)-5,6,7,8-tetrahydrofolic acid. |
| Triglu-5-formyl-tetrahydrofolate | The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with Triglu-5-formyl-tetrahydrofolate. |
| Levoleucovorin | The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with Levoleucovorin. |
| 5-methyltetrahydrofolic acid | The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with 5-methyltetrahydrofolic acid. |
| Thiethylperazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Thiethylperazine. |
| Promazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Promazine. |
| Prochlorperazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Prochlorperazine. |
| Chlorpromazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Chlorpromazine. |
| Triflupromazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Triflupromazine. |
| Fluphenazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Fluphenazine. |
| Thioridazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Thioridazine. |
| Moricizine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Moricizine. |
| Trifluoperazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Trifluoperazine. |
| Perphenazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Perphenazine. |
| Mesoridazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Mesoridazine. |
| Acetophenazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Acetophenazine. |
| Promethazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Promethazine. |
| Alimemazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Alimemazine. |
| Methotrimeprazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Methotrimeprazine. |
| Periciazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Periciazine. |
| Acepromazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Acepromazine. |
| Aceprometazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Aceprometazine. |
| Pipotiazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Pipotiazine. |
| Thioproperazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Thioproperazine. |
| BL-1020 | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with BL-1020. |
| Cyamemazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Cyamemazine. |
| Methylene blue | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Methylene blue. |
| Propiopromazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Propiopromazine. |
| Perazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Perazine. |
| Butaperazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Butaperazine. |
| Chlorproethazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Chlorproethazine. |
| Thiazinam | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Thiazinam. |
| Dixyrazine | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Dixyrazine. |
| Perphenazine enanthate | The risk or severity of QTc prolongation can be increased when Pyrimethamine is combined with Perphenazine enanthate. |
| Dapsone | The risk or severity of adverse effects can be increased when Pyrimethamine is combined with Dapsone. |
| Vemurafenib | The risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Pyrimethamine. |
| Troglitazone | The metabolism of Troglitazone can be decreased when combined with Pyrimethamine. |
| Torasemide | The metabolism of Torasemide can be decreased when combined with Pyrimethamine. |
| Diethylstilbestrol | The metabolism of Diethylstilbestrol can be decreased when combined with Pyrimethamine. |
| Theophylline | The metabolism of Theophylline can be decreased when combined with Pyrimethamine. |
| Morphine | The metabolism of Morphine can be decreased when combined with Pyrimethamine. |
| Amitriptyline | The metabolism of Amitriptyline can be decreased when combined with Pyrimethamine. |
| Diltiazem | The metabolism of Diltiazem can be decreased when combined with Pyrimethamine. |
| Trimethadione | The metabolism of Trimethadione can be decreased when combined with Pyrimethamine. |
| Sulfadiazine | The metabolism of Sulfadiazine can be decreased when combined with Pyrimethamine. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Pyrimethamine. |
| Rosiglitazone | The metabolism of Rosiglitazone can be decreased when combined with Pyrimethamine. |
| Cerivastatin | The metabolism of Cerivastatin can be decreased when combined with Pyrimethamine. |
| Lansoprazole | The metabolism of Lansoprazole can be decreased when combined with Pyrimethamine. |
| Quinine | The metabolism of Quinine can be decreased when combined with Pyrimethamine. |
| Celecoxib | The metabolism of Celecoxib can be decreased when combined with Pyrimethamine. |
| Zidovudine | The metabolism of Zidovudine can be decreased when combined with Pyrimethamine. |
| Cyclophosphamide | The metabolism of Cyclophosphamide can be decreased when combined with Pyrimethamine. |
| Mephenytoin | The metabolism of Mephenytoin can be decreased when combined with Pyrimethamine. |
| Piroxicam | The metabolism of Piroxicam can be decreased when combined with Pyrimethamine. |
| Diclofenac | The metabolism of Diclofenac can be decreased when combined with Pyrimethamine. |
| Cisapride | The metabolism of Cisapride can be decreased when combined with Pyrimethamine. |
| Chloroquine | The metabolism of Chloroquine can be decreased when combined with Pyrimethamine. |
| Amodiaquine | The metabolism of Amodiaquine can be decreased when combined with Pyrimethamine. |
| Paramethadione | The metabolism of Paramethadione can be decreased when combined with Pyrimethamine. |
| Imatinib | The metabolism of Imatinib can be decreased when combined with Pyrimethamine. |
| Nicardipine | The metabolism of Nicardipine can be decreased when combined with Pyrimethamine. |
| Simvastatin | The metabolism of Simvastatin can be decreased when combined with Pyrimethamine. |
| Mycophenolate mofetil | The metabolism of Mycophenolate mofetil can be decreased when combined with Pyrimethamine. |
| Estradiol | The metabolism of Estradiol can be decreased when combined with Pyrimethamine. |
| Naproxen | The metabolism of Naproxen can be decreased when combined with Pyrimethamine. |
| Tazarotene | The metabolism of Tazarotene can be decreased when combined with Pyrimethamine. |
| Propofol | The metabolism of Propofol can be decreased when combined with Pyrimethamine. |
| Loperamide | The metabolism of Loperamide can be decreased when combined with Pyrimethamine. |
| Terbinafine | The metabolism of Terbinafine can be decreased when combined with Pyrimethamine. |
| Repaglinide | The metabolism of Repaglinide can be decreased when combined with Pyrimethamine. |
| Almotriptan | The metabolism of Almotriptan can be decreased when combined with Pyrimethamine. |
| Buprenorphine | The metabolism of Buprenorphine can be decreased when combined with Pyrimethamine. |
| Azelastine | The metabolism of Azelastine can be decreased when combined with Pyrimethamine. |
| Ethinylestradiol | The metabolism of Ethinylestradiol can be decreased when combined with Pyrimethamine. |
| Irbesartan | The metabolism of Irbesartan can be decreased when combined with Pyrimethamine. |
| Selegiline | The metabolism of Selegiline can be decreased when combined with Pyrimethamine. |
| Ibuprofen | The metabolism of Ibuprofen can be decreased when combined with Pyrimethamine. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Pyrimethamine. |
| Fluvastatin | The metabolism of Fluvastatin can be decreased when combined with Pyrimethamine. |
| Tolbutamide | The metabolism of Tolbutamide can be decreased when combined with Pyrimethamine. |
| Pioglitazone | The metabolism of Pioglitazone can be decreased when combined with Pyrimethamine. |
| Ifosfamide | The metabolism of Ifosfamide can be decreased when combined with Pyrimethamine. |
| Domperidone | The metabolism of Domperidone can be decreased when combined with Pyrimethamine. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Pyrimethamine. |
| Halofantrine | The metabolism of Halofantrine can be decreased when combined with Pyrimethamine. |
| Ketamine | The metabolism of Ketamine can be decreased when combined with Pyrimethamine. |
| Lapatinib | The metabolism of Lapatinib can be decreased when combined with Pyrimethamine. |
| Sitagliptin | The metabolism of Sitagliptin can be decreased when combined with Pyrimethamine. |
| Mestranol | The metabolism of Mestranol can be decreased when combined with Pyrimethamine. |
| Aminophenazone | The metabolism of Aminophenazone can be decreased when combined with Pyrimethamine. |
| Antipyrine | The metabolism of Antipyrine can be decreased when combined with Pyrimethamine. |
| Licofelone | The metabolism of Licofelone can be decreased when combined with Pyrimethamine. |
| Beraprost | The metabolism of Beraprost can be decreased when combined with Pyrimethamine. |
| Eltrombopag | The metabolism of Eltrombopag can be decreased when combined with Pyrimethamine. |