Dofetilide

DB00204

small molecule approved investigational

Deskripsi

Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.

Struktur Molekul 2D

Berat 441.565
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10 hours
Volume Distribusi * 3 L/kg
Klirens (Clearance) -

Absorpsi

>90%

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

3 Data
  • 1. Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of dofetilide.
  • 2. Exercise caution with St. John's Wort. Dofetilide is partially metabolized by CYP3A4, and St. John's Wort is a CYP3A4 inducer, coadministration may reduce dofetilide serum levels.
  • 3. Take with or without food.

Interaksi Obat

843 Data
Modafinil The metabolism of Dofetilide can be increased when combined with Modafinil.
Armodafinil The metabolism of Dofetilide can be increased when combined with Armodafinil.
Amiloride Amiloride may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Cimetidine Cimetidine may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Cobicistat The serum concentration of Dofetilide can be increased when it is combined with Cobicistat.
Dolutegravir The serum concentration of Dofetilide can be increased when it is combined with Dolutegravir.
Fingolimod Fingolimod may increase the arrhythmogenic activities of Dofetilide.
Lamotrigine The serum concentration of Dofetilide can be increased when it is combined with Lamotrigine.
Metformin The serum concentration of Dofetilide can be increased when it is combined with Metformin.
Prochlorperazine Prochlorperazine may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Propafenone Propafenone may increase the arrhythmogenic activities of Dofetilide.
Saquinavir The risk or severity of adverse effects can be increased when Saquinavir is combined with Dofetilide.
Triamterene The serum concentration of Dofetilide can be increased when it is combined with Triamterene.
Trimethoprim Trimethoprim may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Verapamil The serum concentration of Dofetilide can be increased when it is combined with Verapamil.
Torasemide The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Torasemide is combined with Dofetilide.
Furosemide The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Furosemide is combined with Dofetilide.
Bumetanide The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Bumetanide is combined with Dofetilide.
Etacrynic acid The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Etacrynic acid is combined with Dofetilide.
Piretanide The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Piretanide is combined with Dofetilide.
Azosemide The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Azosemide is combined with Dofetilide.
Tripamide The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Tripamide is combined with Dofetilide.
Methyclothiazide The risk or severity of QTc prolongation can be increased when Methyclothiazide is combined with Dofetilide.
Chlorthalidone The risk or severity of QTc prolongation can be increased when Chlorthalidone is combined with Dofetilide.
Bendroflumethiazide The risk or severity of QTc prolongation can be increased when Bendroflumethiazide is combined with Dofetilide.
Metolazone The risk or severity of QTc prolongation can be increased when Metolazone is combined with Dofetilide.
Benzthiazide The risk or severity of QTc prolongation can be increased when Benzthiazide is combined with Dofetilide.
Hydroflumethiazide The risk or severity of QTc prolongation can be increased when Hydroflumethiazide is combined with Dofetilide.
Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Dofetilide.
Chlorothiazide The risk or severity of QTc prolongation can be increased when Chlorothiazide is combined with Dofetilide.
Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Trichlormethiazide The risk or severity of QTc prolongation can be increased when Trichlormethiazide is combined with Dofetilide.
Polythiazide The risk or severity of QTc prolongation can be increased when Polythiazide is combined with Dofetilide.
Quinethazone The risk or severity of QTc prolongation can be increased when Quinethazone is combined with Dofetilide.
Cyclopenthiazide The risk or severity of QTc prolongation can be increased when Cyclopenthiazide is combined with Dofetilide.
Epitizide The risk or severity of QTc prolongation can be increased when Epitizide is combined with Dofetilide.
Metreleptin The metabolism of Dofetilide can be increased when combined with Metreleptin.
Bupropion The excretion of Dofetilide can be decreased when combined with Bupropion.
Megestrol acetate Megestrol acetate may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Crizotinib The metabolism of Dofetilide can be decreased when combined with Crizotinib.
Atenolol Dofetilide may increase the arrhythmogenic activities of Atenolol.
Acetyldigitoxin Dofetilide may increase the arrhythmogenic activities of Acetyldigitoxin.
Carteolol Dofetilide may increase the arrhythmogenic activities of Carteolol.
Magnesium sulfate Dofetilide may increase the arrhythmogenic activities of Magnesium sulfate.
Alprenolol Dofetilide may increase the arrhythmogenic activities of Alprenolol.
Tocainide Dofetilide may increase the arrhythmogenic activities of Tocainide.
Deslanoside Dofetilide may increase the arrhythmogenic activities of Deslanoside.
Nadolol Dofetilide may increase the arrhythmogenic activities of Nadolol.
Metipranolol Dofetilide may increase the arrhythmogenic activities of Metipranolol.
Practolol Dofetilide may increase the arrhythmogenic activities of Practolol.
Aprindine Dofetilide may increase the arrhythmogenic activities of Aprindine.
Dexpropranolol Dofetilide may increase the arrhythmogenic activities of Dexpropranolol.
Xylometazoline Dofetilide may increase the arrhythmogenic activities of Xylometazoline.
Sparteine Dofetilide may increase the arrhythmogenic activities of Sparteine.
Fasudil Dofetilide may increase the arrhythmogenic activities of Fasudil.
Nicorandil Dofetilide may increase the arrhythmogenic activities of Nicorandil.
Tropisetron Dofetilide may increase the arrhythmogenic activities of Tropisetron.
Landiolol Dofetilide may increase the arrhythmogenic activities of Landiolol.
Spiradoline Dofetilide may increase the arrhythmogenic activities of Spiradoline.
Cymarin Dofetilide may increase the arrhythmogenic activities of Cymarin.
Tiracizine Dofetilide may increase the arrhythmogenic activities of Tiracizine.
Ethacizine Dofetilide may increase the arrhythmogenic activities of Ethacizine.
Hydroquinine Dofetilide may increase the arrhythmogenic activities of Hydroquinine.
Bioallethrin Dofetilide may increase the arrhythmogenic activities of Bioallethrin.
Tertatolol Dofetilide may increase the arrhythmogenic activities of Tertatolol.
Fosfructose Dofetilide may increase the arrhythmogenic activities of Fosfructose.
Fosinoprilat Dofetilide may increase the arrhythmogenic activities of Fosinoprilat.
Hydroquinidine Dofetilide may increase the arrhythmogenic activities of Hydroquinidine.
SOR-C13 Dofetilide may increase the arrhythmogenic activities of SOR-C13.
Betaxolol Betaxolol may increase the arrhythmogenic activities of Dofetilide.
Atropine Dofetilide may increase the arrhythmogenic activities of Atropine.
Adenosine Dofetilide may increase the arrhythmogenic activities of Adenosine.
Levosimendan Dofetilide may increase the arrhythmogenic activities of Levosimendan.
Acebutolol Dofetilide may increase the arrhythmogenic activities of Acebutolol.
Flecainide Dofetilide may increase the arrhythmogenic activities of Flecainide.
Oxprenolol Dofetilide may increase the arrhythmogenic activities of Oxprenolol.
Azimilide Dofetilide may increase the arrhythmogenic activities of Azimilide.
Tedisamil Dofetilide may increase the arrhythmogenic activities of Tedisamil.
Melperone Dofetilide may increase the arrhythmogenic activities of Melperone.
Simendan Dofetilide may increase the arrhythmogenic activities of Simendan.
Nizofenone Dofetilide may increase the arrhythmogenic activities of Nizofenone.
Bunaftine Dofetilide may increase the arrhythmogenic activities of Bunaftine.
Lorcainide Dofetilide may increase the arrhythmogenic activities of Lorcainide.
Esmolol Esmolol may increase the arrhythmogenic activities of Dofetilide.
Timolol Dofetilide may increase the arrhythmogenic activities of Timolol.
Hyoscyamine Dofetilide may increase the arrhythmogenic activities of Hyoscyamine.
Moricizine Dofetilide may increase the arrhythmogenic activities of Moricizine.
Bretylium Dofetilide may increase the arrhythmogenic activities of Bretylium.
Encainide Dofetilide may increase the arrhythmogenic activities of Encainide.
Ajmaline Dofetilide may increase the arrhythmogenic activities of Ajmaline.
Celiprolol Dofetilide may increase the arrhythmogenic activities of Celiprolol.
Methsuximide Dofetilide may increase the arrhythmogenic activities of Methsuximide.
Vernakalant Dofetilide may increase the arrhythmogenic activities of Vernakalant.
Cariporide Dofetilide may increase the arrhythmogenic activities of Cariporide.
Bupranolol Dofetilide may increase the arrhythmogenic activities of Bupranolol.
Indenolol Dofetilide may increase the arrhythmogenic activities of Indenolol.
Talinolol Dofetilide may increase the arrhythmogenic activities of Talinolol.
Anisodamine Dofetilide may increase the arrhythmogenic activities of Anisodamine.
Pilsicainide Dofetilide may increase the arrhythmogenic activities of Pilsicainide.
Cicletanine Dofetilide may increase the arrhythmogenic activities of Cicletanine.

Target Protein

Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2
Potassium channel subfamily K member 2 KCNK2
ATP-sensitive inward rectifier potassium channel 12 KCNJ12

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10907968
    Lenz TL, Hilleman DE: Dofetilide, a new class III antiarrhythmic agent. Pharmacotherapy. 2000 Jul;20(7):776-86.
  • PMID: 12845335
    Lenz TL, Hilleman DE: Dofetilide: A new antiarrhythmic agent approved for conversion and/or maintenance of atrial fibrillation/atrial flutter. Drugs Today (Barc). 2000 Nov;36(11):759-71.
  • PMID: 10486417
    Torp-Pedersen C, Moller M, Bloch-Thomsen PE, Kober L, Sandoe E, Egstrup K, Agner E, Carlsen J, Videbaek J, Marchant B, Camm AJ: Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. N Engl J Med. 1999 Sep 16;341(12):857-65.

Contoh Produk & Brand

Produk: 72 • International brands: 0
Produk
  • Dofetilide
    Capsule • 125 ug/1 • Oral • US • Generic • Approved
  • Dofetilide
    Capsule • 250 ug/1 • Oral • US • Generic • Approved
  • Dofetilide
    Capsule • 500 ug/1 • Oral • US • Generic • Approved
  • Dofetilide
    Capsule • 0.125 mg/1 • Oral • US • Generic • Approved
  • Dofetilide
    Capsule • 0.25 mg/1 • Oral • US • Generic • Approved
  • Dofetilide
    Capsule • 0.5 mg/1 • Oral • US • Generic • Approved
  • Dofetilide
    Capsule • 125 ug/1 • Oral • US • Generic • Approved
  • Dofetilide
    Capsule • 250 ug/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 72 produk.

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