Aspartame

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) At room temperature, aspartame is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7, its half-life is shortened to only a few days.

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Absorbed in the small intestine, aspartame is metabolized and absorbed very quickly.

Metabolisme

Approximately 10% of aspartame (by weight) is broken down into methanol in the small intestine. Most of the methanol is absorbed and quickly converted into formaldehyde. Approximately 50% of aspartame (by weight) is broken down into phenylalanine. Approximately 40% of aspartame (by mass) is broken down into aspartic acid.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

80 Data

Succinic acid	The excretion of Succinic acid can be decreased when combined with Aspartame.
Citrulline	The excretion of Citrulline can be decreased when combined with Aspartame.
Pravastatin	The excretion of Pravastatin can be decreased when combined with Aspartame.
Oseltamivir	The excretion of Oseltamivir can be decreased when combined with Aspartame.
Cefotiam	The excretion of Cefotiam can be decreased when combined with Aspartame.
Conjugated estrogens	The excretion of Conjugated estrogens can be decreased when combined with Aspartame.
Tenofovir disoproxil	The excretion of Tenofovir disoproxil can be decreased when combined with Aspartame.
Piperacillin	The excretion of Piperacillin can be decreased when combined with Aspartame.
Indomethacin	The excretion of Indomethacin can be decreased when combined with Aspartame.
Aminohippuric acid	The excretion of Aminohippuric acid can be decreased when combined with Aspartame.
Trifluridine	The excretion of Trifluridine can be decreased when combined with Aspartame.
Allopurinol	The excretion of Allopurinol can be decreased when combined with Aspartame.
Zidovudine	The excretion of Zidovudine can be decreased when combined with Aspartame.
Cimetidine	The excretion of Cimetidine can be decreased when combined with Aspartame.
Cefdinir	The excretion of Cefdinir can be decreased when combined with Aspartame.
Methotrexate	The excretion of Methotrexate can be decreased when combined with Aspartame.
Cephalexin	The excretion of Cephalexin can be decreased when combined with Aspartame.
Valaciclovir	The excretion of Valaciclovir can be decreased when combined with Aspartame.
Levocarnitine	The excretion of Levocarnitine can be decreased when combined with Aspartame.
Leucovorin	The excretion of Leucovorin can be decreased when combined with Aspartame.
Fluorescein	The excretion of Fluorescein can be decreased when combined with Aspartame.
Hydrocortisone	The excretion of Hydrocortisone can be decreased when combined with Aspartame.
Tetracycline	The excretion of Tetracycline can be decreased when combined with Aspartame.
Estradiol	The excretion of Estradiol can be decreased when combined with Aspartame.
Acyclovir	The excretion of Acyclovir can be decreased when combined with Aspartame.
Cefaclor	The excretion of Cefaclor can be decreased when combined with Aspartame.
Ranitidine	The excretion of Ranitidine can be decreased when combined with Aspartame.
Quinapril	The excretion of Quinapril can be decreased when combined with Aspartame.
Bumetanide	The excretion of Bumetanide can be decreased when combined with Aspartame.
Dinoprostone	The excretion of Dinoprostone can be decreased when combined with Aspartame.
Famotidine	The excretion of Famotidine can be decreased when combined with Aspartame.
Fexofenadine	The excretion of Fexofenadine can be decreased when combined with Aspartame.
Benzylpenicillin	The excretion of Benzylpenicillin can be decreased when combined with Aspartame.
Rosuvastatin	The excretion of Rosuvastatin can be decreased when combined with Aspartame.
Captopril	The excretion of Captopril can be decreased when combined with Aspartame.
Sitagliptin	The excretion of Sitagliptin can be decreased when combined with Aspartame.
Cefazolin	The excretion of Cefazolin can be decreased when combined with Aspartame.
Ceftizoxime	The excretion of Ceftizoxime can be decreased when combined with Aspartame.
Cefacetrile	The excretion of Cefacetrile can be decreased when combined with Aspartame.
Ceftibuten	The excretion of Ceftibuten can be decreased when combined with Aspartame.
Tazobactam	The excretion of Tazobactam can be decreased when combined with Aspartame.
Cyclic adenosine monophosphate	The excretion of Cyclic adenosine monophosphate can be decreased when combined with Aspartame.
Cholic Acid	The excretion of Cholic Acid can be decreased when combined with Aspartame.
Glutaric Acid	The excretion of Glutaric Acid can be decreased when combined with Aspartame.
Oxalic Acid	The excretion of Oxalic Acid can be decreased when combined with Aspartame.
Taurocholic acid	The excretion of Taurocholic acid can be decreased when combined with Aspartame.
Doripenem	The excretion of Doripenem can be decreased when combined with Aspartame.
Saxagliptin	The excretion of Saxagliptin can be decreased when combined with Aspartame.
Ellagic acid	The excretion of Ellagic acid can be decreased when combined with Aspartame.
Cefaloridine	The excretion of Cefaloridine can be decreased when combined with Aspartame.
Avibactam	The excretion of Avibactam can be decreased when combined with Aspartame.
Eluxadoline	The excretion of Eluxadoline can be decreased when combined with Aspartame.
Silibinin	The excretion of Silibinin can be decreased when combined with Aspartame.
Tenofovir alafenamide	The excretion of Tenofovir alafenamide can be decreased when combined with Aspartame.
Baricitinib	The serum concentration of Baricitinib can be increased when it is combined with Aspartame.
Relebactam	The excretion of Relebactam can be decreased when combined with Aspartame.
Tenofovir	The excretion of Tenofovir can be decreased when combined with Aspartame.
Hydrochlorothiazide	The excretion of Hydrochlorothiazide can be decreased when combined with Aspartame.
Dexamethasone	The excretion of Dexamethasone can be decreased when combined with Aspartame.
Oxytetracycline	The excretion of Oxytetracycline can be decreased when combined with Aspartame.
Polythiazide	The excretion of Polythiazide can be decreased when combined with Aspartame.
Prednisolone phosphate	The excretion of Prednisolone phosphate can be decreased when combined with Aspartame.
Dexamethasone acetate	The excretion of Dexamethasone acetate can be decreased when combined with Aspartame.
Acamprosate	The excretion of Acamprosate can be decreased when combined with Aspartame.
Pemetrexed	Aspartame may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Mercaptopurine	The excretion of Mercaptopurine can be decreased when combined with Aspartame.
Valproic acid	The excretion of Valproic acid can be decreased when combined with Aspartame.
Clofarabine	The excretion of Clofarabine can be decreased when combined with Aspartame.
Grepafloxacin	The excretion of Grepafloxacin can be decreased when combined with Aspartame.
Cidofovir	The excretion of Cidofovir can be decreased when combined with Aspartame.
Stavudine	The excretion of Stavudine can be decreased when combined with Aspartame.
Lamivudine	The excretion of Lamivudine can be decreased when combined with Aspartame.
Adefovir dipivoxil	The excretion of Adefovir dipivoxil can be decreased when combined with Aspartame.
Didanosine	The excretion of Didanosine can be decreased when combined with Aspartame.
Zalcitabine	The excretion of Zalcitabine can be decreased when combined with Aspartame.
Levofloxacin	The excretion of Levofloxacin can be decreased when combined with Aspartame.
Vadadustat	The serum concentration of Vadadustat can be increased when it is combined with Aspartame.
Sulbactam	The excretion of Sulbactam can be decreased when combined with Aspartame.
Seladelpar	The excretion of Seladelpar can be decreased when combined with Aspartame.
Sulopenem etzadroxil	The serum concentration of Sulopenem etzadroxil can be increased when it is combined with Aspartame.

Target Protein

Taste receptor type 1 member 3 TAS1R3

Taste receptor type 1 member 2 TAS1R2

Transient receptor potential cation channel subfamily V member 1 TRPV1

Referensi & Sumber

Synthesis reference: Josef Tsau, "Convenient to use aspartame and method of making." U.S. Patent US5582351, issued August, 1972.

Contoh Produk & Brand

Produk: 0 • International brands: 4

International Brands

Aminosweet — Ajinomoto
Canderel — Merisant
Equal — Merisant
Nutrasweet — NutraSweet

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan

Deskripsi

Struktur Molekul 2D

Deskripsi metode visualisasi