Icosapent

DB00159

small molecule approved nutraceutical

Deskripsi

Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.

Struktur Molekul 2D

Berat 302.451
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1382 Data
Ibrutinib Icosapent may increase the antiplatelet activities of Ibrutinib.
Amlodipine Icosapent may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Icosapent is combined with Phentermine.
Midodrine The risk or severity of hypertension can be increased when Icosapent is combined with Midodrine.
Eletriptan The risk or severity of hypertension can be increased when Icosapent is combined with Eletriptan.
Isoetharine The risk or severity of hypertension can be increased when Icosapent is combined with Isoetharine.
Ziprasidone The risk or severity of hypertension can be increased when Icosapent is combined with Ziprasidone.
Methysergide The risk or severity of hypertension can be increased when Icosapent is combined with Methysergide.
Cabergoline The risk or severity of hypertension can be increased when Icosapent is combined with Cabergoline.
Zolmitriptan The risk or severity of hypertension can be increased when Icosapent is combined with Zolmitriptan.
Dihydroergotamine The risk or severity of hypertension can be increased when Icosapent is combined with Dihydroergotamine.
Methylergometrine The risk or severity of hypertension can be increased when Icosapent is combined with Methylergometrine.
Norepinephrine The risk or severity of hypertension can be increased when Icosapent is combined with Norepinephrine.
Mirtazapine The risk or severity of hypertension can be increased when Icosapent is combined with Mirtazapine.
Phenylephrine The risk or severity of hypertension can be increased when Icosapent is combined with Phenylephrine.
Phenylpropanolamine The risk or severity of hypertension can be increased when Icosapent is combined with Phenylpropanolamine.
Promazine The risk or severity of hypertension can be increased when Icosapent is combined with Promazine.
Droperidol The risk or severity of hypertension can be increased when Icosapent is combined with Droperidol.
Doxapram The risk or severity of hypertension can be increased when Icosapent is combined with Doxapram.
Atropine The risk or severity of hypertension can be increased when Icosapent is combined with Atropine.
Lisuride The risk or severity of hypertension can be increased when Icosapent is combined with Lisuride.
Linezolid The risk or severity of hypertension can be increased when Icosapent is combined with Linezolid.
Metaraminol The risk or severity of hypertension can be increased when Icosapent is combined with Metaraminol.
Furazolidone The risk or severity of hypertension can be increased when Icosapent is combined with Furazolidone.
Epinephrine The risk or severity of hypertension can be increased when Icosapent is combined with Epinephrine.
Thioridazine The risk or severity of hypertension can be increased when Icosapent is combined with Thioridazine.
Ergotamine The risk or severity of hypertension can be increased when Icosapent is combined with Ergotamine.
Nicergoline The risk or severity of hypertension can be increased when Icosapent is combined with Nicergoline.
Sufentanil The risk or severity of hypertension can be increased when Icosapent is combined with Sufentanil.
Methoxamine The risk or severity of hypertension can be increased when Icosapent is combined with Methoxamine.
Risperidone The risk or severity of hypertension can be increased when Icosapent is combined with Risperidone.
Tranylcypromine The risk or severity of hypertension can be increased when Icosapent is combined with Tranylcypromine.
Isoflurane The risk or severity of hypertension can be increased when Icosapent is combined with Isoflurane.
Propiomazine The risk or severity of hypertension can be increased when Icosapent is combined with Propiomazine.
Alfentanil The risk or severity of hypertension can be increased when Icosapent is combined with Alfentanil.
Minaprine The risk or severity of hypertension can be increased when Icosapent is combined with Minaprine.
Orciprenaline The risk or severity of hypertension can be increased when Icosapent is combined with Orciprenaline.
Propofol The risk or severity of hypertension can be increased when Icosapent is combined with Propofol.
Phenmetrazine The risk or severity of hypertension can be increased when Icosapent is combined with Phenmetrazine.
Trifluoperazine The risk or severity of hypertension can be increased when Icosapent is combined with Trifluoperazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Icosapent is combined with Pseudoephedrine.
Benzphetamine The risk or severity of hypertension can be increased when Icosapent is combined with Benzphetamine.
Ritodrine The risk or severity of hypertension can be increased when Icosapent is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Icosapent is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Icosapent is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Icosapent is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Icosapent is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Icosapent is combined with Diethylpropion.
Salmeterol The risk or severity of hypertension can be increased when Icosapent is combined with Salmeterol.
Naratriptan The risk or severity of hypertension can be increased when Icosapent is combined with Naratriptan.
Formoterol The risk or severity of hypertension can be increased when Icosapent is combined with Formoterol.
Frovatriptan The risk or severity of hypertension can be increased when Icosapent is combined with Frovatriptan.
Methoxyflurane The risk or severity of hypertension can be increased when Icosapent is combined with Methoxyflurane.
Selegiline The risk or severity of hypertension can be increased when Icosapent is combined with Selegiline.
Ergoloid mesylate The risk or severity of hypertension can be increased when Icosapent is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Icosapent is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Icosapent is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Icosapent is combined with Dutasteride.
Halothane The risk or severity of hypertension can be increased when Icosapent is combined with Halothane.
Moclobemide The risk or severity of hypertension can be increased when Icosapent is combined with Moclobemide.
Pergolide The risk or severity of hypertension can be increased when Icosapent is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Icosapent is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Icosapent is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Icosapent is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Icosapent is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Icosapent is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Icosapent is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Icosapent is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Icosapent is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Icosapent is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Icosapent is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Icosapent is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Icosapent is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Icosapent is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Icosapent is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Icosapent is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Icosapent is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Icosapent is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Icosapent is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Icosapent is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Icosapent is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Icosapent is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Icosapent is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Icosapent is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Icosapent is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Icosapent is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Icosapent is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Icosapent is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Icosapent is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Icosapent is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Icosapent is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Icosapent is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Icosapent is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Icosapent is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Icosapent is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Icosapent is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Icosapent is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Icosapent is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Icosapent is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Icosapent is combined with Flibanserin.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1
Peroxisome proliferator-activated receptor gamma PPARG
Peroxisome proliferator-activated receptor delta PPARD
Free fatty acid receptor 1 FFAR1
Sodium/calcium exchanger 1 SLC8A1
Fatty acid-binding protein, brain FABP7
Acyl-CoA (8-3)-desaturase FADS1
Long-chain-fatty-acid--CoA ligase 4 ACSL4
Transient receptor potential cation channel subfamily V member 1 TRPV1
Peroxisome proliferator-activated receptor alpha PPARA
Polyunsaturated fatty acid 5-lipoxygenase ALOX5

Referensi & Sumber

Synthesis reference: Akira Seto, Shoko Yamashita, "Method of preparing fatty acid composition containing high concentration of eicosapentaenoic acid." U.S. Patent US4615839, issued March, 1983.
Artikel (PubMed)
  • PMID: 21683321
    Bays HE, Ballantyne CM, Kastelein JJ, Isaacsohn JL, Braeckman RA, Soni PN: Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension MARINE trial). Am J Cardiol. 2011 Sep 1;108(5):682-90. doi: 10.1016/j.amjcard.2011.04.015. Epub 2011 Jun 16.

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