Peringatan Keamanan

No reports of overdose, however, high doses of NADH (10 mg a day or more) may cause jitteriness, anxiety, and insomnia.

NADH

DB00157

small molecule approved nutraceutical

Deskripsi

NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed)

Struktur Molekul 2D

Berat 665.441
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Unclear how much of an administered dose is absorbed.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

NADH-ubiquinone oxidoreductase chain 3 MT-ND3
UDP-glucose 6-dehydrogenase UGDH
Alcohol dehydrogenase 1A ADH1A
Sorbitol dehydrogenase SORD
All-trans-retinol dehydrogenase [NAD(+)] ADH4 ADH4
Alcohol dehydrogenase 1C ADH1C
All-trans-retinol dehydrogenase [NAD(+)] ADH1B ADH1B
All-trans-retinol dehydrogenase [NAD(+)] ADH7 ADH7
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic GPD1
L-lactate dehydrogenase A-like 6A LDHAL6A
Alcohol dehydrogenase class-3 ADH5
Aldo-keto reductase family 1 member B1 AKR1B1
3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10
Malate dehydrogenase, mitochondrial MDH2
L-lactate dehydrogenase A chain LDHA
NAD-dependent malic enzyme, mitochondrial ME2
Peroxisomal multifunctional enzyme type 2 HSD17B4
L-lactate dehydrogenase A-like 6B LDHAL6B
L-lactate dehydrogenase C chain LDHC
L-lactate dehydrogenase B chain LDHB
Peroxisomal bifunctional enzyme EHHADH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH
NADP-dependent malic enzyme, mitochondrial ME3
D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1
Malate dehydrogenase, cytoplasmic MDH1
3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH
17-beta-hydroxysteroid dehydrogenase type 3 HSD17B3
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR
NADP-dependent malic enzyme ME1
D-3-phosphoglycerate dehydrogenase PHGDH
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 HSD17B7
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A
17-beta-hydroxysteroid dehydrogenase type 1 HSD17B1
17-beta-hydroxysteroid dehydrogenase type 2 HSD17B2
Retinol dehydrogenase 5 RDH5
GDH/6PGL endoplasmic bifunctional protein H6PD
(3R)-3-hydroxyacyl-CoA dehydrogenase HSD17B8
Aldo-keto reductase family 1 member C4 AKR1C4
Inosine-5'-monophosphate dehydrogenase 2 IMPDH2
Aldo-keto reductase family 1 member C3 AKR1C3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD
GDP-L-fucose synthase GFUS
Aldo-keto reductase family 1 member C1 AKR1C1
11-beta-hydroxysteroid dehydrogenase 1 HSD11B1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 HSD3B2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1
Inosine-5'-monophosphate dehydrogenase 1 IMPDH1
Trifunctional enzyme subunit alpha, mitochondrial HADHA
Aldehyde dehydrogenase, mitochondrial ALDH2
11-beta-hydroxysteroid dehydrogenase type 2 HSD11B2
Aldo-keto reductase family 1 member C2 AKR1C2
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL
Aldehyde dehydrogenase family 3 member B2 ALDH3B2
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1
Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1
Aldehyde dehydrogenase 1A1 ALDH1A1
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS
4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1
Retinaldehyde dehydrogenase 3 ALDH1A3
Aldehyde dehydrogenase X, mitochondrial ALDH1B1
Aldehyde dehydrogenase family 3 member B1 ALDH3B1
Glyceraldehyde-3-phosphate dehydrogenase GAPDH
Retinal dehydrogenase 2 ALDH1A2
Aldehyde dehydrogenase family 3 member A2 ALDH3A2
Succinate-semialdehyde dehydrogenase, mitochondrial ALDH5A1
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1
Flavin reductase (NADPH) BLVRB
Pyrroline-5-carboxylate reductase 2 PYCR2
Pyrroline-5-carboxylate reductase 1, mitochondrial PYCR1
Glutamate dehydrogenase 1, mitochondrial GLUD1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial PDHA2
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial PDHA1
Biliverdin reductase A BLVRA
Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS
Dihydrofolate reductase DHFR
2-oxoglutarate dehydrogenase complex component E1 OGDH
Glutamate dehydrogenase 2, mitochondrial GLUD2
7-dehydrocholesterol reductase DHCR7
Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2
NADH-ubiquinone oxidoreductase chain 2 MT-ND2
Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1
NADH-cytochrome b5 reductase 3 CYB5R3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11
NADH-ubiquinone oxidoreductase chain 4 MT-ND4
Dihydropteridine reductase QDPR
NADH-ubiquinone oxidoreductase chain 1 MT-ND1
NAD(P) transhydrogenase, mitochondrial NNT
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9
NADH-ubiquinone oxidoreductase chain 4L MT-ND4L
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1
NADH-ubiquinone oxidoreductase chain 6 MT-ND6
NADH-ubiquinone oxidoreductase chain 5 MT-ND5
Cytochrome c oxidase subunit NDUFA4 NDUFA4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6
Acyl carrier protein, mitochondrial NDUFAB1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8
NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3
Dihydrolipoyl dehydrogenase, mitochondrial DLD
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3
Glutathione reductase, mitochondrial GSR
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13
Cysteine dioxygenase type 1 CDO1
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8
Cytochrome P450 4A11 CYP4A11
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT
Aminomethyltransferase, mitochondrial AMT
Methylsterol monooxygenase 1 MSMO1
Heme oxygenase 1 HMOX1
Heme oxygenase 2 HMOX2
Steroid 17-alpha-hydroxylase/17,20 lyase CYP17A1
Tyrosinase TYR

Referensi & Sumber

Synthesis reference: Youichi Niimura, Michio Kozaki, Hisashi Yamagata, Miki Ikuta, Yasurou Kurusu, Hideaki Yukawa, Makiko Kukushima, Masato Terasausa, "Process for producing NADH oxidase." U.S. Patent US5416012, issued February, 1984.
Artikel (PubMed)
  • PMID: 17161604
    Belenky P, Bogan KL, Brenner C: NAD+ metabolism in health and disease. Trends Biochem Sci. 2007 Jan;32(1):12-9. Epub 2006 Dec 11.
  • PMID: 17295611
    Pollak N, Dolle C, Ziegler M: The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J. 2007 Mar 1;402(2):205-18.
  • PMID: 17465726
    Khan JA, Forouhar F, Tao X, Tong L: Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets. 2007 May;11(5):695-705.
  • PMID: 12648681
    Lin SJ, Guarente L: Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol. 2003 Apr;15(2):241-6.
  • PMID: 218616
    Biellmann JF, Lapinte C, Haid E, Weimann G: Structure of lactate dehydrogenase inhibitor generated from coenzyme. Biochemistry. 1979 Apr 3;18(7):1212-7.

Contoh Produk & Brand

Produk: 23 • International brands: 0
Produk
  • Amladex
    Tablet • - • Oral • US
  • BumP DHA
    Capsule • - • Oral • US
  • BumP DHA
    Capsule • - • Oral • US
  • EnBrace HR
    Capsule, delayed release pellets • - • Oral • US
  • Enl
    Capsule, liquid filled • - • Oral • US
  • EnLyte
    Capsule, delayed release pellets • - • Oral • US
  • Folika-V
    Tablet • - • Oral • US
  • Genicin Vita-Q
    Tablet • - • Oral • US
Menampilkan 8 dari 23 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul