Citrulline

DB00155

small molecule investigational nutraceutical

Deskripsi

Citrulline is an amino acid. It is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated.

Struktur Molekul 2D

Berat 175.1857
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

136 Data
Aspartame The excretion of Citrulline can be decreased when combined with Aspartame.
Pravastatin The excretion of Citrulline can be decreased when combined with Pravastatin.
Pantoprazole The excretion of Citrulline can be decreased when combined with Pantoprazole.
Cefotiam The excretion of Citrulline can be decreased when combined with Cefotiam.
Liothyronine The excretion of Citrulline can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Citrulline can be decreased when combined with Conjugated estrogens.
Valproic acid The excretion of Citrulline can be decreased when combined with Valproic acid.
Indomethacin The excretion of Citrulline can be decreased when combined with Indomethacin.
Aminohippuric acid The excretion of Citrulline can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Citrulline can be decreased when combined with Lansoprazole.
Cefalotin The excretion of Citrulline can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Citrulline can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Citrulline can be decreased when combined with Cefotaxime.
Zidovudine The excretion of Citrulline can be decreased when combined with Zidovudine.
Cimetidine The excretion of Citrulline can be decreased when combined with Cimetidine.
Guanidine The excretion of Citrulline can be decreased when combined with Guanidine.
Piroxicam The excretion of Citrulline can be decreased when combined with Piroxicam.
Methotrexate The excretion of Citrulline can be decreased when combined with Methotrexate.
Cephalexin The excretion of Citrulline can be decreased when combined with Cephalexin.
Enalapril The excretion of Citrulline can be decreased when combined with Enalapril.
Diclofenac The excretion of Citrulline can be decreased when combined with Diclofenac.
Oxytetracycline The excretion of Citrulline can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Citrulline can be decreased when combined with Leucovorin.
Furosemide The excretion of Citrulline can be decreased when combined with Furosemide.
Esomeprazole The excretion of Citrulline can be decreased when combined with Esomeprazole.
Tetracycline The excretion of Citrulline can be decreased when combined with Tetracycline.
Acyclovir The excretion of Citrulline can be decreased when combined with Acyclovir.
Phenylbutazone The excretion of Citrulline can be decreased when combined with Phenylbutazone.
Cefaclor The excretion of Citrulline can be decreased when combined with Cefaclor.
Bumetanide The excretion of Citrulline can be decreased when combined with Bumetanide.
Quinidine The excretion of Citrulline can be decreased when combined with Quinidine.
Dinoprostone The excretion of Citrulline can be decreased when combined with Dinoprostone.
Famotidine The excretion of Citrulline can be decreased when combined with Famotidine.
Salicylic acid The excretion of Citrulline can be decreased when combined with Salicylic acid.
Acetylsalicylic acid The excretion of Citrulline can be decreased when combined with Acetylsalicylic acid.
Ganciclovir The excretion of Citrulline can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Citrulline can be decreased when combined with Ketoprofen.
Minocycline The excretion of Citrulline can be decreased when combined with Minocycline.
Probenecid The excretion of Citrulline can be decreased when combined with Probenecid.
Mercaptopurine The excretion of Citrulline can be decreased when combined with Mercaptopurine.
Ibuprofen The excretion of Citrulline can be decreased when combined with Ibuprofen.
Novobiocin The excretion of Citrulline can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Citrulline can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Citrulline can be decreased when combined with Melatonin.
Ouabain The excretion of Citrulline can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Citrulline can be decreased when combined with Rosuvastatin.
Cefadroxil The excretion of Citrulline can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Citrulline can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Citrulline can be decreased when combined with Cefamandole.
Cefazolin The excretion of Citrulline can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Citrulline can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Citrulline can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Citrulline can be decreased when combined with Cefacetrile.
Ceftibuten The excretion of Citrulline can be decreased when combined with Ceftibuten.
Liotrix The excretion of Citrulline can be decreased when combined with Liotrix.
Cilastatin The excretion of Citrulline can be decreased when combined with Cilastatin.
Tazobactam The excretion of Citrulline can be decreased when combined with Tazobactam.
trans-2-hydroxycinnamic acid The excretion of Citrulline can be decreased when combined with trans-2-hydroxycinnamic acid.
Topiroxostat The excretion of Citrulline can be decreased when combined with Topiroxostat.
Cholic Acid The excretion of Citrulline can be decreased when combined with Cholic Acid.
Glutaric Acid The excretion of Citrulline can be decreased when combined with Glutaric Acid.
Benzoic acid The excretion of Citrulline can be decreased when combined with Benzoic acid.
Taurocholic acid The excretion of Citrulline can be decreased when combined with Taurocholic acid.
Caprylic acid The excretion of Citrulline can be decreased when combined with Caprylic acid.
Ataluren The excretion of Citrulline can be decreased when combined with Ataluren.
Teriflunomide The excretion of Citrulline can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Citrulline can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Citrulline can be decreased when combined with Dolutegravir.
Cefaloridine The excretion of Citrulline can be decreased when combined with Cefaloridine.
Lenvatinib The excretion of Citrulline can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Citrulline can be decreased when combined with Cabotegravir.
Apalutamide The excretion of Citrulline can be decreased when combined with Apalutamide.
Pradigastat The excretion of Citrulline can be decreased when combined with Pradigastat.
Enasidenib The excretion of Citrulline can be decreased when combined with Enasidenib.
Gemfibrozil The excretion of Citrulline can be decreased when combined with Gemfibrozil.
Dronedarone The excretion of Citrulline can be decreased when combined with Dronedarone.
Favipiravir The excretion of Citrulline can be decreased when combined with Favipiravir.
Tafamidis The excretion of Citrulline can be decreased when combined with Tafamidis.
Linezolid The excretion of Citrulline can be decreased when combined with Linezolid.
Testosterone The excretion of Citrulline can be increased when combined with Testosterone.
Methyltestosterone The excretion of Citrulline can be increased when combined with Methyltestosterone.
Testosterone cypionate The excretion of Citrulline can be increased when combined with Testosterone cypionate.
Testosterone enanthate The excretion of Citrulline can be increased when combined with Testosterone enanthate.
Cyclosporine The excretion of Citrulline can be decreased when combined with Cyclosporine.
Riboflavin The excretion of Citrulline can be decreased when combined with Riboflavin.
Ethoxzolamide The excretion of Citrulline can be decreased when combined with Ethoxzolamide.
Codeine The excretion of Citrulline can be decreased when combined with Codeine.
Piperacillin The excretion of Citrulline can be decreased when combined with Piperacillin.
Cidofovir The excretion of Citrulline can be decreased when combined with Cidofovir.
Trifluridine The excretion of Citrulline can be decreased when combined with Trifluridine.
Chloramphenicol The excretion of Citrulline can be decreased when combined with Chloramphenicol.
Tolmetin The excretion of Citrulline can be decreased when combined with Tolmetin.
Caspofungin The excretion of Citrulline can be decreased when combined with Caspofungin.
Foscarnet The excretion of Citrulline can be decreased when combined with Foscarnet.
Carbenicillin The excretion of Citrulline can be decreased when combined with Carbenicillin.
Sulindac The excretion of Citrulline can be decreased when combined with Sulindac.
Cyclothiazide The excretion of Citrulline can be decreased when combined with Cyclothiazide.
Nafcillin The excretion of Citrulline can be decreased when combined with Nafcillin.
Chlorpropamide The excretion of Citrulline can be decreased when combined with Chlorpropamide.
Fluorescein The excretion of Citrulline can be decreased when combined with Fluorescein.

Target Protein

Nitric oxide synthase 3 NOS3
Argininosuccinate synthase ASS1
Putative hydrolase DDAH2 DDAH2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1
Ornithine transcarbamylase, mitochondrial OTC
Nitric oxide synthase 1 NOS1
Nitric oxide synthase, inducible NOS2
Protein-arginine deiminase type-4 PADI4
Protein-arginine deiminase type-6 PADI6
Protein-arginine deiminase type-1 PADI1
Protein-arginine deiminase type-3 PADI3
Protein-arginine deiminase type-2 PADI2

Referensi & Sumber

Synthesis reference: Hua Bai, Peijie Yang, Zhengjie Chen, Chongyan Xu, Zhaorul Li, Zigang Zhao, Luyan Jiang, Zongyi Yang, Jiang Li, "PROCESSES FOR THE PRODUCTION OF L-CITRULLINE." U.S. Patent US20090142813, issued June 04, 2009.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Lipovite
    Injection • - • Intramuscular • US
  • tensioSAN
    Tablet • - • Oral • US

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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