Peringatan Keamanan

ORL-MUS LD50 5000 mg/kg, IPR-MUS LD50 4020 mg/kg, SCU-MUS LD50 5000 mg/kg, IVN-RBT LD50 > 2000 mg/kg, IMS-MUS LD50 4000 mg/kg

Glutathione

DB00143

small molecule approved investigational nutraceutical

Deskripsi

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Struktur Molekul 2D

Berat 307.323
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Research suggests that glutathione is not orally bioactive, and that very little of oral glutathione tablets or capsules is actually absorbed by the body.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

Aldo-keto reductase family 1 member B1 AKR1B1
Matrix metalloproteinase-9 MMP9
Cytochrome P450 3A4 CYP3A4
Glutathione peroxidase GPX5
Glutathione reductase, mitochondrial GSR
Glutathione synthetase GSS
Glutathione S-transferase Mu 1 GSTM1
Glutathione S-transferase kappa 1 GSTK1
Glutathione S-transferase A3 GSTA3
Glutathione S-transferase Mu 3 GSTM3
Glutathione S-transferase A4 GSTA4
Glutathione S-transferase Mu 4 GSTM4
Glutathione S-transferase A5 GSTA5
Glutathione S-transferase P GSTP1
Glutathione S-transferase omega-1 GSTO1
Glutathione peroxidase 1 GPX1
Glutathione peroxidase 2 GPX2
Glutathione S-transferase theta-1 GSTT1
Maleylacetoacetate isomerase GSTZ1
Epididymal secretory glutathione peroxidase GPX5
Glutathione peroxidase 3 GPX3
Lactoylglutathione lyase GLO1
Leukotriene C4 synthase LTC4S
Glutathione S-transferase 3, mitochondrial MGST3
Hematopoietic prostaglandin D synthase HPGDS
Glutathione S-transferase A1 GSTA1
Glutathione S-transferase A2 GSTA2
Microsomal glutathione S-transferase 1 MGST1
S-formylglutathione hydrolase ESD
Glutathione hydrolase 1 proenzyme GGT1
Glutathione S-transferase Mu 2 GSTM2
Glutaredoxin-1 GLRX
Phospholipid hydroperoxide glutathione peroxidase GPX4 GPX4
Glutathione S-transferase Mu 5 GSTM5
Glutathione peroxidase 6 GPX6
Hydroxyacylglutathione hydrolase, mitochondrial HAGH
Glutathione peroxidase GPX1
Glutathione peroxidase 7 GPX7
Microsomal glutathione S-transferase 2 MGST2
Glutathione S-transferase omega-2 GSTO2
Glutaredoxin-2, mitochondrial GLRX2

Referensi & Sumber

Synthesis reference: Akihiro Mizutani, "Complexes of polysaccharides or derivatives thereof with reduced glutathione and process for preparing said complexes." U.S. Patent US4009264, issued February, 1971.
Artikel (PubMed)
  • PMID: 15955607
    Struzynska L, Chalimoniuk M, Sulkowski G: The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity. Toxicology. 2005 Sep 1;212(2-3):185-94.
  • PMID: 1362956
    Witschi A, Reddy S, Stofer B, Lauterburg BH: The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667-9.
  • PMID: 8207209
    Yim CY, Hibbs JB Jr, McGregor JR, Galinsky RE, Samlowski WE: Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J Immunol. 1994 Jun 15;152(12):5796-805.
  • PMID: 16427183
    Drevet JR: The antioxidant glutathione peroxidase family and spermatozoa: a complex story. Mol Cell Endocrinol. 2006 May 16;250(1-2):70-9. Epub 2006 Jan 19.
  • PMID: 14988435
    Wu G, Fang YZ, Yang S, Lupton JR, Turner ND: Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92.

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Produk: 9 • International brands: 1
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Menampilkan 8 dari 9 produk.
International Brands
  • Isethion

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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