Peringatan Keamanan

Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.

Methionine

DB00134

small molecule approved nutraceutical

Deskripsi

A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.

Struktur Molekul 2D

Berat 149.211

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data

1. Take with food.

Interaksi Obat

1 Data

Levodopa

The therapeutic efficacy of Levodopa can be decreased when used in combination with Methionine.

Target Protein

Methionine synthase reductase MTRR

Methionine synthase MTR

Methionine aminopeptidase 2 METAP2

Betaine--homocysteine S-methyltransferase 1 BHMT

S-methylmethionine--homocysteine S-methyltransferase BHMT2 BHMT2

Referensi & Sumber

Synthesis reference: Clyde Eugene Stauffer, "Process for producing N-acyl-L-methionine." U.S. Patent US3963573, issued June, 1950.

Contoh Produk & Brand

Produk: 245 • International brands: 1

Produk

2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose

Solution • - • Intravenous • Canada • Approved
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix

Solution • - • Intravenous • Canada • Approved
2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix

Solution • - • Intravenous • Canada • Approved
2.5%travasol Amino Acid InJ.W.eleC.W.25%dex

Liquid • - • Intravenous • Canada • Approved
2.75% Travas. Amino Acid InJ.W.elecw.25%dex

Liquid • - • Intravenous • Canada • Approved
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix

Solution • - • Intravenous • Canada • Approved
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix

Solution • - • Intravenous • Canada • Approved
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.

Liquid • - • Intravenous • Canada • Approved

Menampilkan 8 dari 245 produk.

International Brands

Acimethin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.