alpha-Linolenic acid

DB00132

small molecule approved investigational nutraceutical

Deskripsi

Alpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition.

Struktur Molekul 2D

Berat 278.4296
Wujud liquid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1 Data
Ibrutinib alpha-Linolenic acid may increase the antiplatelet activities of Ibrutinib.

Target Protein

Free fatty acid receptor 1 FFAR1
Prostaglandin G/H synthase 2 PTGS2
Acyl-CoA (8-3)-desaturase FADS1
Acyl-CoA 6-desaturase FADS2
Transient receptor potential cation channel subfamily V member 1 TRPV1
Peroxisome proliferator-activated receptor alpha PPARA
Bile acid receptor NR1H4
Peroxisome proliferator-activated receptor delta PPARD
Peroxisome proliferator-activated receptor gamma PPARG
Retinoic acid receptor RXR-alpha RXRA
Very long chain fatty acid elongase 2 ELOVL2
Very long chain fatty acid elongase 5 ELOVL5
Sodium/calcium exchanger 1 SLC8A1

Referensi & Sumber

Synthesis reference: Jean-Pierre Masse, "Therapeutic composition containing alpha-linolenic acid and a compound capable of promoting the passage of the acid through the cell membrane, plant extract comprising the acid and the compound, and process for the preparation of the extract." U.S. Patent US5002767, issued February, 1986.
Artikel (PubMed)
  • PMID: 12438303
    Kris-Etherton PM, Harris WS, Appel LJ: Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002 Nov 19;106(21):2747-57.
  • PMID: 10617967
    Connor WE: Importance of n-3 fatty acids in health and disease. Am J Clin Nutr. 2000 Jan;71(1 Suppl):171S-5S.
  • PMID: 15051847
    Brouwer IA, Katan MB, Zock PL: Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr. 2004 Apr;134(4):919-22.
  • PMID: 11157315
    Cho E, Hung S, Willett WC, Spiegelman D, Rimm EB, Seddon JM, Colditz GA, Hankinson SE: Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr. 2001 Feb;73(2):209-18.
  • PMID: 10775263
    Lauritzen I, Blondeau N, Heurteaux C, Widmann C, Romey G, Lazdunski M: Polyunsaturated fatty acids are potent neuroprotectors. EMBO J. 2000 Apr 17;19(8):1784-93.

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Menampilkan 8 dari 9 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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