Ascorbic acid

DB00126

small molecule approved nutraceutical

Deskripsi

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Struktur Molekul 2D

Berat 176.1241
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 16 days (3.4 hours in people who have excess levels of vitamin C)
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

70% to 90%

Metabolisme

Hepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid multivalent ions. Do not infuse with elemental compounds that can be reduced, such as copper.

Interaksi Obat

64 Data
Aluminum hydroxide Ascorbic acid can cause an increase in the absorption of Aluminum hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.
Bortezomib The therapeutic efficacy of Bortezomib can be decreased when used in combination with Ascorbic acid.
Deferoxamine The risk or severity of Cardiovascular Impairment can be increased when Ascorbic acid is combined with Deferoxamine.
Chlorpropamide Ascorbic acid may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Mecamylamine Ascorbic acid may increase the excretion rate of Mecamylamine which could result in a lower serum level and potentially a reduction in efficacy.
Cyclosporine The serum concentration of Cyclosporine can be decreased when it is combined with Ascorbic acid.
Chlorotrianisene The serum concentration of Ascorbic acid can be decreased when it is combined with Chlorotrianisene.
Estrone The serum concentration of Ascorbic acid can be decreased when it is combined with Estrone.
Dienestrol The serum concentration of Ascorbic acid can be decreased when it is combined with Dienestrol.
Polyestradiol phosphate The serum concentration of Ascorbic acid can be decreased when it is combined with Polyestradiol phosphate.
Mestranol The serum concentration of Ascorbic acid can be decreased when it is combined with Mestranol.
Quinestrol The serum concentration of Ascorbic acid can be decreased when it is combined with Quinestrol.
Hexestrol The serum concentration of Ascorbic acid can be decreased when it is combined with Hexestrol.
Synthetic Conjugated Estrogens, A The serum concentration of Ascorbic acid can be decreased when it is combined with Synthetic Conjugated Estrogens, A.
Synthetic Conjugated Estrogens, B The serum concentration of Ascorbic acid can be decreased when it is combined with Synthetic Conjugated Estrogens, B.
Zeranol The serum concentration of Ascorbic acid can be decreased when it is combined with Zeranol.
Equol The serum concentration of Ascorbic acid can be decreased when it is combined with Equol.
Epimestrol The serum concentration of Ascorbic acid can be decreased when it is combined with Epimestrol.
Tibolone The serum concentration of Ascorbic acid can be decreased when it is combined with Tibolone.
Promestriene The serum concentration of Ascorbic acid can be decreased when it is combined with Promestriene.
Methallenestril The serum concentration of Ascorbic acid can be decreased when it is combined with Methallenestril.
Moxestrol The serum concentration of Ascorbic acid can be decreased when it is combined with Moxestrol.
Esterified estrogens The serum concentration of Ascorbic acid can be decreased when it is combined with Esterified estrogens.
Estrone sulfate The serum concentration of Ascorbic acid can be decreased when it is combined with Estrone sulfate.
Biochanin A The serum concentration of Ascorbic acid can be decreased when it is combined with Biochanin A.
Formononetin The serum concentration of Ascorbic acid can be decreased when it is combined with Formononetin.
Diethylstilbestrol The serum concentration of Ascorbic acid can be decreased when it is combined with Diethylstilbestrol.
Conjugated estrogens The serum concentration of Ascorbic acid can be decreased when it is combined with Conjugated estrogens.
Estradiol The serum concentration of Ascorbic acid can be decreased when it is combined with Estradiol.
Ethinylestradiol The serum concentration of Ascorbic acid can be decreased when it is combined with Ethinylestradiol.
Estriol The serum concentration of Ascorbic acid can be decreased when it is combined with Estriol.
Estradiol acetate The serum concentration of Ascorbic acid can be decreased when it is combined with Estradiol acetate.
Estradiol benzoate The serum concentration of Ascorbic acid can be decreased when it is combined with Estradiol benzoate.
Estradiol cypionate The serum concentration of Ascorbic acid can be decreased when it is combined with Estradiol cypionate.
Estradiol valerate The serum concentration of Ascorbic acid can be decreased when it is combined with Estradiol valerate.
Estetrol The serum concentration of Ascorbic acid can be decreased when it is combined with Estetrol.
Amphetamine The serum concentration of Amphetamine can be decreased when it is combined with Ascorbic acid.
Phentermine The serum concentration of Phentermine can be decreased when it is combined with Ascorbic acid.
Benzphetamine The serum concentration of Benzphetamine can be decreased when it is combined with Ascorbic acid.
Diethylpropion The serum concentration of Diethylpropion can be decreased when it is combined with Ascorbic acid.
Lisdexamfetamine The serum concentration of Lisdexamfetamine can be decreased when it is combined with Ascorbic acid.
Mephentermine The serum concentration of Mephentermine can be decreased when it is combined with Ascorbic acid.
MMDA The serum concentration of MMDA can be decreased when it is combined with Ascorbic acid.
Midomafetamine The serum concentration of Midomafetamine can be decreased when it is combined with Ascorbic acid.
2,5-Dimethoxy-4-ethylamphetamine The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Ascorbic acid.
4-Bromo-2,5-dimethoxyamphetamine The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Ascorbic acid.
Tenamfetamine The serum concentration of Tenamfetamine can be decreased when it is combined with Ascorbic acid.
Chlorphentermine The serum concentration of Chlorphentermine can be decreased when it is combined with Ascorbic acid.
Methylenedioxyethamphetamine The serum concentration of Methylenedioxyethamphetamine can be decreased when it is combined with Ascorbic acid.
Dextroamphetamine The serum concentration of Dextroamphetamine can be decreased when it is combined with Ascorbic acid.
Metamfetamine The serum concentration of Metamfetamine can be decreased when it is combined with Ascorbic acid.
Iofetamine I-123 The serum concentration of Iofetamine I-123 can be decreased when it is combined with Ascorbic acid.
Ritobegron The serum concentration of Ritobegron can be decreased when it is combined with Ascorbic acid.
Mephedrone The serum concentration of Mephedrone can be decreased when it is combined with Ascorbic acid.
Methoxyphenamine The serum concentration of Methoxyphenamine can be decreased when it is combined with Ascorbic acid.
Gepefrine The serum concentration of Gepefrine can be decreased when it is combined with Ascorbic acid.
2,5-Dimethoxy-4-ethylthioamphetamine The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Ascorbic acid.
Phendimetrazine The serum concentration of Phendimetrazine can be decreased when it is combined with Ascorbic acid.
Erythromycin The therapeutic efficacy of Erythromycin can be decreased when used in combination with Ascorbic acid.
Kanamycin The therapeutic efficacy of Kanamycin can be decreased when used in combination with Ascorbic acid.
Streptomycin The therapeutic efficacy of Streptomycin can be decreased when used in combination with Ascorbic acid.
Doxycycline The therapeutic efficacy of Doxycycline can be decreased when used in combination with Ascorbic acid.
Lincomycin The therapeutic efficacy of Lincomycin can be decreased when used in combination with Ascorbic acid.
Bleomycin The therapeutic efficacy of Bleomycin can be decreased when used in combination with Ascorbic acid.

Target Protein

Solute carrier family 23 member 2 SLC23A2
Solute carrier family 23 member 1 SLC23A1
Hyaluronate lyase
DNA
Xylose isomerase xylA
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 PLOD2
Phytanoyl-CoA dioxygenase, peroxisomal PHYH
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 PLOD3
Gamma-butyrobetaine dioxygenase BBOX1
Dopamine beta-hydroxylase DBH
Peptidyl-glycine alpha-amidating monooxygenase PAM
Prolyl 3-hydroxylase 1 P3H1
Prolyl 3-hydroxylase 2 P3H2
Prolyl 3-hydroxylase 3 P3H3
Prolyl 4-hydroxylase subunit alpha-1 P4HA1
Prolyl 3-hydroxylase OGFOD1 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 OGFOD2
DNA oxidative demethylase ALKBH2 ALKBH2
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3
Lysine-specific demethylase 5D KDM5D
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1
Trimethyllysine dioxygenase, mitochondrial TMLHE
Transmembrane prolyl 4-hydroxylase P4HTM
Egl nine homolog 1 EGLN1
Prolyl hydroxylase EGLN2 EGLN2
Prolyl hydroxylase EGLN3 EGLN3

Referensi & Sumber

Synthesis reference: Lewis D. Morse, Paul A. Hammes, "Beverage containing stabilized vitamin C and iron and method of making same." U.S. Patent US3958017, issued October, 1972.
Artikel (PubMed)
  • PMID: 12569111
    Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M: Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.
  • PMID: 8144521
    Meister A: Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem. 1994 Apr 1;269(13):9397-400.
  • PMID: 3015170
    Englard S, Seifter S: The biochemical functions of ascorbic acid. Annu Rev Nutr. 1986;6:365-406.
  • PMID: 11458272
    Banhegyi G, Mandl J: The hepatic glycogenoreticular system. Pathol Oncol Res. 2001;7(2):107-10.
  • PMID: 5477017
    Proctor P: Similar functions of uric acid and ascorbate in man? Nature. 1970 Nov 28;228(5274):868.
  • PMID: 14642847
    Korcok J, Dixon SJ, Lo TC, Wilson JX: Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes. Brain Res. 2003 Dec 12;993(1-2):201-7.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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