Peringatan Keamanan

Oral supplementation with L-arginine at doses up to 15 grams daily are generally well tolerated. The most common adverse reactions of higher doses from 15 to 30 grams daily are nausea, abdominal cramps and diarrhea. Some may experience these symptoms at lower doses.

Arginine

DB00125

small molecule investigational nutraceutical

Deskripsi

An essential amino acid that is physiologically active in the L-form.

Struktur Molekul 2D

Berat 174.201
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed from the lumen of the small intestine into the enterocytes. Absorption is efficient and occurs by an active transport mechanism.

Metabolisme

Some metabolism of L-arginine takes place in the enterocytes. L-arginine not metabolized in the enterocytes enters the portal circulation from whence it is transported to the liver, where again some portion of the amino acid is metabolized.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

Cationic amino acid transporter 3 SLC7A3
Antizyme inhibitor 2 AZIN2
Argininosuccinate lyase ASL
Nitric oxide synthase, inducible NOS2
High affinity cationic amino acid transporter 1 SLC7A1
Arginase-2, mitochondrial ARG2
Cationic amino acid transporter 4 SLC7A4
Argininosuccinate synthase ASS1
Nitric oxide synthase 3 NOS3

Referensi & Sumber

Synthesis reference: Kiyoshi Nakayama, Kazumi Araki, Hajime Yoshida, "Process for the production of L-arginine by fermentation." U.S. Patent US4086137, issued May, 1973.
Artikel (PubMed)
  • PMID: 15465778
    Morris SM Jr: Enzymes of arginine metabolism. J Nutr. 2004 Oct;134(10 Suppl):2743S-2747S; discussion 2765S-2767S.
  • PMID: 16391217
    Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S, Ernst KV, Kelemen MD, Townsend SN, Capriotti A, Hare JM, Gerstenblith G: L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA. 2006 Jan 4;295(1):58-64.
  • PMID: 2903866
    Alba-Roth J, Muller OA, Schopohl J, von Werder K: Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9.

Contoh Produk & Brand

Produk: 238 • International brands: 1
Produk
  • 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose
    Solution • - • Intravenous • Canada • Approved
  • 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix
    Solution • - • Intravenous • Canada • Approved
  • 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix
    Solution • - • Intravenous • Canada • Approved
  • 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex
    Liquid • - • Intravenous • Canada • Approved
  • 2.75% Travas. Amino Acid InJ.W.elecw.25%dex
    Liquid • - • Intravenous • Canada • Approved
  • 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix
    Solution • - • Intravenous • Canada • Approved
  • 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix
    Solution • - • Intravenous • Canada • Approved
  • 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.
    Liquid • - • Intravenous • Canada • Approved
Menampilkan 8 dari 238 produk.
International Brands
  • R-Gene 10 — Pharmacia Corp.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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