Lysine

DB00123

small molecule approved nutraceutical

Deskripsi

Lysine (abbreviated as Lys or K) is an ?-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ?-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ?-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

Struktur Molekul 2D

Berat 146.1876

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Absorbed from the lumen of the small intestine into the enterocytes by an active transport process

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

High affinity cationic amino acid transporter 1 SLC7A1

Cationic amino acid transporter 4 SLC7A4

Cationic amino acid transporter 3 SLC7A3

Cationic amino acid transporter 2 SLC7A2

Lysine--tRNA ligase KARS1

Referensi & Sumber

Synthesis reference: Joseph Michael Stevens, Thomas P. Binder, "Process for making granular L-lysine." U.S. Patent US5990350, issued 0000.

Artikel (PubMed)

PMID: 640102
Griffith RS, Norins AL, Kagan C: A multicentered study of lysine therapy in Herpes simplex infection. Dermatologica. 1978;156(5):257-67.

Contoh Produk & Brand

Produk: 240 • International brands: 0

Produk

2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose

Solution • - • Intravenous • Canada • Approved
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix

Solution • - • Intravenous • Canada • Approved
2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix

Solution • - • Intravenous • Canada • Approved
2.5%travasol Amino Acid InJ.W.eleC.W.25%dex

Liquid • - • Intravenous • Canada • Approved
2.75% Travas. Amino Acid InJ.W.elecw.25%dex

Liquid • - • Intravenous • Canada • Approved
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix

Solution • - • Intravenous • Canada • Approved
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix

Solution • - • Intravenous • Canada • Approved
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.

Liquid • - • Intravenous • Canada • Approved

Menampilkan 8 dari 240 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.