Peringatan Keamanan

Oral rat LD50: 3400 mg/kg

Choline

DB00122

small molecule approved nutraceutical

Deskripsi

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Struktur Molekul 2D

Berat 104.1708
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

111 Data
Bupropion The excretion of Choline can be decreased when combined with Bupropion.
Tipiracil The excretion of Tipiracil can be decreased when combined with Choline.
Varenicline The excretion of Varenicline can be decreased when combined with Choline.
Prazosin The serum concentration of Prazosin can be increased when it is combined with Choline.
Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Choline.
Metformin The serum concentration of Metformin can be increased when it is combined with Choline.
Norepinephrine The serum concentration of Norepinephrine can be increased when it is combined with Choline.
Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Choline.
Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Choline.
Choline salicylate The serum concentration of Choline salicylate can be increased when it is combined with Choline.
Nicotine The serum concentration of Choline can be increased when it is combined with Nicotine.
Ranolazine The serum concentration of Choline can be increased when it is combined with Ranolazine.
Metoprolol The serum concentration of Choline can be increased when it is combined with Metoprolol.
Disopyramide The serum concentration of Choline can be increased when it is combined with Disopyramide.
Aminohippuric acid The serum concentration of Choline can be increased when it is combined with Aminohippuric acid.
Grepafloxacin The serum concentration of Choline can be increased when it is combined with Grepafloxacin.
Progesterone The serum concentration of Choline can be increased when it is combined with Progesterone.
Imipramine The serum concentration of Choline can be increased when it is combined with Imipramine.
Quinine The serum concentration of Choline can be increased when it is combined with Quinine.
Guanidine The serum concentration of Choline can be increased when it is combined with Guanidine.
Lamotrigine The serum concentration of Choline can be increased when it is combined with Lamotrigine.
Propranolol The serum concentration of Choline can be increased when it is combined with Propranolol.
Amiloride The serum concentration of Choline can be increased when it is combined with Amiloride.
Imatinib The serum concentration of Choline can be increased when it is combined with Imatinib.
Flurazepam The serum concentration of Choline can be increased when it is combined with Flurazepam.
Clopidogrel The serum concentration of Choline can be increased when it is combined with Clopidogrel.
Estradiol The serum concentration of Choline can be increased when it is combined with Estradiol.
Quinidine The serum concentration of Choline can be increased when it is combined with Quinidine.
Phenformin The serum concentration of Choline can be increased when it is combined with Phenformin.
Dinoprostone The serum concentration of Choline can be increased when it is combined with Dinoprostone.
Phenoxybenzamine The serum concentration of Choline can be increased when it is combined with Phenoxybenzamine.
Famotidine The serum concentration of Choline can be increased when it is combined with Famotidine.
Salmeterol The serum concentration of Choline can be increased when it is combined with Salmeterol.
Probenecid The serum concentration of Choline can be increased when it is combined with Probenecid.
Diphenhydramine The serum concentration of Choline can be increased when it is combined with Diphenhydramine.
Quinacrine The serum concentration of Choline can be increased when it is combined with Quinacrine.
Chlorpheniramine The serum concentration of Choline can be increased when it is combined with Chlorpheniramine.
Amiodarone The serum concentration of Choline can be increased when it is combined with Amiodarone.
Desipramine The serum concentration of Choline can be increased when it is combined with Desipramine.
Oxprenolol The serum concentration of Choline can be increased when it is combined with Oxprenolol.
Dronedarone The serum concentration of Choline can be increased when it is combined with Dronedarone.
Vandetanib The serum concentration of Choline can be increased when it is combined with Vandetanib.
Pimagedine The serum concentration of Choline can be increased when it is combined with Pimagedine.
Tafenoquine The serum concentration of Choline can be increased when it is combined with Tafenoquine.
Crizotinib The serum concentration of Choline can be increased when it is combined with Crizotinib.
Dolutegravir The serum concentration of Choline can be increased when it is combined with Dolutegravir.
Lenvatinib The serum concentration of Choline can be increased when it is combined with Lenvatinib.
Dexchlorpheniramine maleate The serum concentration of Choline can be increased when it is combined with Dexchlorpheniramine maleate.
Isavuconazole The serum concentration of Choline can be increased when it is combined with Isavuconazole.
Tucatinib The serum concentration of Choline can be increased when it is combined with Tucatinib.
Apalutamide The serum concentration of Choline can be increased when it is combined with Apalutamide.
Erdafitinib The serum concentration of Choline can be increased when it is combined with Erdafitinib.
Enasidenib The serum concentration of Choline can be increased when it is combined with Enasidenib.
Estradiol acetate The serum concentration of Choline can be increased when it is combined with Estradiol acetate.
Estradiol benzoate The serum concentration of Choline can be increased when it is combined with Estradiol benzoate.
Estradiol cypionate The serum concentration of Choline can be increased when it is combined with Estradiol cypionate.
Estradiol dienanthate The serum concentration of Choline can be increased when it is combined with Estradiol dienanthate.
Estradiol valerate The serum concentration of Choline can be increased when it is combined with Estradiol valerate.
Reserpine The serum concentration of Reserpine can be increased when it is combined with Choline.
Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Choline.
Cimetidine The serum concentration of Cimetidine can be increased when it is combined with Choline.
Epinephrine The serum concentration of Epinephrine can be increased when it is combined with Choline.
Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Choline.
Amantadine The serum concentration of Amantadine can be increased when it is combined with Choline.
Dopamine The serum concentration of Dopamine can be increased when it is combined with Choline.
Memantine The serum concentration of Memantine can be increased when it is combined with Choline.
Histamine The serum concentration of Histamine can be increased when it is combined with Choline.
Agmatine The serum concentration of Agmatine can be increased when it is combined with Choline.
Nafamostat The serum concentration of Nafamostat can be increased when it is combined with Choline.
Methylene blue The serum concentration of Choline can be increased when it is combined with Methylene blue.
Trilaciclib The serum concentration of Choline can be increased when it is combined with Trilaciclib.
Spermine The risk or severity of adverse effects can be increased when Choline is combined with Spermine.
Codeine The risk or severity of adverse effects can be increased when Choline is combined with Codeine.
Verapamil The risk or severity of adverse effects can be increased when Choline is combined with Verapamil.
Rocuronium The risk or severity of adverse effects can be increased when Choline is combined with Rocuronium.
Acyclovir The risk or severity of adverse effects can be increased when Choline is combined with Acyclovir.
Cytarabine The risk or severity of adverse effects can be increased when Choline is combined with Cytarabine.
Ganciclovir The risk or severity of adverse effects can be increased when Choline is combined with Ganciclovir.
Tubocurarine The risk or severity of adverse effects can be increased when Choline is combined with Tubocurarine.
Pancuronium The risk or severity of adverse effects can be increased when Choline is combined with Pancuronium.
Acetylcholine The risk or severity of adverse effects can be increased when Choline is combined with Acetylcholine.
Spermidine The risk or severity of adverse effects can be increased when Choline is combined with Spermidine.
Buformin The risk or severity of adverse effects can be increased when Choline is combined with Buformin.
Nelfinavir The risk or severity of adverse effects can be increased when Nelfinavir is combined with Choline.
Indinavir The risk or severity of adverse effects can be increased when Indinavir is combined with Choline.
Nevirapine The risk or severity of adverse effects can be increased when Nevirapine is combined with Choline.
Doxazosin The risk or severity of adverse effects can be increased when Doxazosin is combined with Choline.
Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Choline.
Saquinavir The risk or severity of adverse effects can be increased when Saquinavir is combined with Choline.
Palbociclib The risk or severity of adverse effects can be increased when Palbociclib is combined with Choline.
Pitolisant The risk or severity of adverse effects can be increased when Pitolisant is combined with Choline.
Dacomitinib The risk or severity of adverse effects can be increased when Dacomitinib is combined with Choline.
Gilteritinib The risk or severity of adverse effects can be increased when Gilteritinib is combined with Choline.
Formoterol The risk or severity of adverse effects can be increased when Choline is combined with Formoterol.
Guanfacine The risk or severity of adverse effects can be increased when Choline is combined with Guanfacine.
Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Choline.
Cisplatin The serum concentration of Cisplatin can be increased when it is combined with Choline.
Oxaliplatin The serum concentration of Oxaliplatin can be increased when it is combined with Choline.
Procainamide The serum concentration of Procainamide can be increased when it is combined with Choline.
Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Choline.

Target Protein

Neuronal acetylcholine receptor subunit alpha-2 CHRNA2
Neuronal acetylcholine receptor subunit alpha-7 CHRNA7
Choline-phosphate cytidylyltransferase B PCYT1B
Acetylcholinesterase ACHE
Choline-phosphate cytidylyltransferase A PCYT1A
Phospholipase D2 PLD2
Cholinesterase BCHE
Phospholipase D1 PLD1
Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1

Referensi & Sumber

Synthesis reference: Satishchandra P. Patel, Vinayak T. Bhalani, "Solid choline magnesium salicylate composition and method of preparing same." U.S. Patent US5043168, issued May, 1954.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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